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Curr Org Synth ; 17(3): 243-250, 2020.
Article in English | MEDLINE | ID: mdl-32096746

ABSTRACT

Design of chemically novel, biologically potent small heterocyclic molecules with anticancer activities, which targets the enzyme heparanase has gained prominent clinical interest. We have synthesized a novel class of carboxamide derivatives by coupling various substituted aromatic acid hydrazides and triazoleamine with pyrrolidine carboxylic acid by using coupling agents. The synthesized compounds are characterized by spectroscopic techniques such as FT-IR, HRMS and NMR. These compounds are investigated for cytotoxicity on different cancer cell lines and heparanase inhibitory activity. Most of them showed moderate heparanase inhibitory activity and good cytotoxicity.


Subject(s)
Antineoplastic Agents/pharmacology , Enzyme Inhibitors/pharmacology , Glucuronidase/antagonists & inhibitors , Hydrazines/pharmacology , Pyrrolidinones/pharmacology , Triazoles/pharmacology , Animals , Antineoplastic Agents/chemical synthesis , Cell Line, Tumor , Enzyme Inhibitors/chemical synthesis , Humans , Hydrazines/chemical synthesis , Mice , Pyrrolidinones/chemical synthesis , Triazoles/chemical synthesis
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