Subject(s)
COVID-19 , Respiratory Insufficiency , Humans , Wakefulness , Feasibility Studies , SARS-CoV-2 , Respiration, ArtificialSubject(s)
Bronchiolitis , Child , Humans , Infant , Bronchiolitis/therapy , Cannula , Ventilators, Mechanical , Oxygen Inhalation TherapyABSTRACT
We thank Salama S et al [...].
Subject(s)
Positive-Pressure Respiration , Pulmonary Disease, Chronic Obstructive , Humans , Lung , Pulmonary Disease, Chronic Obstructive/therapy , RespirationABSTRACT
BACKGROUND: Maintenance of adequate depth of anaesthesia in spine surgery is vital to prevent awareness, to reduce stress response and possible autonomic instability frequently associated with spine surgery. Dexmedetomidine, a α2-adrenoceptor agonist with analgesic and sedative adjuvant property has been found to reduce dose requirement of multiple anaesthetic agents both for induction and during the maintenance of anaesthesia. AIM: The aim of this study is to observe the effect of dexmedetomidine, on the requirement of propofol for induction and maintenance of adequate depth of anaesthesia during spine surgery. METHODS: It was a prospective, randomised, double-blinded, parallel group, placebo controlled and open-lebel study in tertiary care hospital. A total of 70 patients aged 20-60 years, American Society of Anaesthesiologists GradeI and II, scheduled for elective spine surgery were randomly allocated into two groups. Each patient of Group D (n=35) received an initial loading dose of dexmedetomidine at 1 µg/kg over 10 min, started 15 min before induction of anaesthesia followed by an infusion at a rate of 0.2 µg/kg/h. Patients of Group P (n=35) received the same volume of 0.9% normal saline solution as placebo. Requirement of propofol at induction and during maintenance was calculated maintaining bispectral index between 40 and 60. P<0.05 was considered to be statistically significant. RESULTS: Mean requirement of propofol was found to be lessened by 48.08% and 61.87% for induction and maintenance of anaesthesia respectively while using dexmedetomidine. CONCLUSION: Administration of dexmedetomidine significantly reduces the requirement of propofol while maintaining desired depth of anaesthesia without any significant complication.
