A compact and open-source microcontroller-based rapid auto-alignment system.

Maintaining stable and precise alignment of a laser beam is crucial in many optical setups. In this work, we present a microcontroller-based rapid auto-alignment system that detects and corrects for drifts in a laser beam trajectory using a pair of two-dimensional duo-lateral position sensing detectors (PSDs) and a pair of mirror mounts with piezoelectric actuators. We develop hardware and software for interfacing with the PSDs and for controlling the motion of the piezoelectric mirror mounts. Our auto-alignment strategy-implemented as a state machine on the microcontroller by a real-time operating system kernel from FreeRTOS-is based on a simple linearized geometrical optical model. We benchmark our system using the standard case of coupling laser light efficiently into the guided mode of a single-mode fiber optic patch cable. We can recover the maximum fiber coupling efficiency in ∼10 seconds, even for a laser beam misaligned to the point of zero fiber coupling efficiency.

Coherence measurements of polaritons in thermal equilibrium reveal a power law for two-dimensional condensates.

We have created a spatially homogeneous polariton condensate in thermal equilibrium, up to very high condensate fraction. Under these conditions, we have measured the coherence as a function of momentum and determined the total coherent fraction of this boson system from very low density up to density well above the condensation transition. These measurements reveal a consistent power law for the coherent fraction as a function of the total density over nearly three orders of its magnitude. The same power law is seen in numerical simulations solving the two-dimensional Gross-Pitaevskii equation for the equilibrium coherence.

Critical fluctuations in a confined driven-dissipative quantum condensate.

Phase fluctuations determine the low-energy properties of quantum condensates. However, at the condensation threshold, both density and phase fluctuations are relevant. While strong emphasis has been given to the investigation of phase fluctuations, which dominate the physics of the quantum system away from the critical point, number fluctuations have been much less explored even in thermal equilibrium. In this work, we report experimental observation and theoretical description of fluctuations in a circularly confined nonequilibrium Bose-Einstein condensate of polaritons near the condensation threshold. We observe critical fluctuations, which combine the number fluctuations of a single-mode condensate state and competition between different states. The latter is analogous to mode hopping in photon lasers. Our theoretical analysis indicates that this phenomenon is of a quantum character, while classical noise of the pump is not sufficient to explain the experiments. The manifestation of a critical quantum state competition unlocks possibilities for the study of condensate formation while linking to practical realizations in photonic lasers.

Papertronics: Marriage between Paper and Electronics Becoming a Real Scenario in Resource-Limited Settings.

Integrating electronic applications with paper, placed next to or below printed images or graphics, can further expand the possible uses of paper substrates. Consuming paper as a substrate in the field of electronics can lead to significant innovations toward papertronics applications as paper comprises various advantages like being disposable, inexpensive, biodegradable, easy to handle, simple to use, and easily available. All of these advantages will definitely spur the advancement of the electronics field, but unfortunately, putting electronics on paper is not an easy task because, compared to plastics, the paper surface is not just rough but also porous. For example, in the case of lateral flow assay testing the sensor response is delayed if the pore size of the paper is enormous. This might be a disadvantage for most electrical devices printed directly on paper. Still, some methods make it compatible when fit with a rough, absorbent surface of the paper. Building electronic devices on a standard paper substrate have sparked much interest because of its lightweight, environmental friendliness, minimal cost, and simple fabrication. A slew of improvements have been achieved in recent years to make paper electronics perform better in various applications, including transistors, batteries, and displays. In addition, flexible electronics have gained much interest in human-machine interaction and wireless sensing. This review briefly examines the origins and fabrication of paper electronics and then moves on to applications and exciting possible paths for paper-based electronics.

State of the Art in Smart Portable, Wearable, Ingestible and Implantable Devices for Health Status Monitoring and Disease Management.

Several illnesses that are chronic and acute are becoming more relevant as the world's aging population expands, and the medical sector is transforming rapidly, as a consequence of which the need for "point-of-care" (POC), identification/detection, and real time management of health issues that have been required for a long time are increasing. Biomarkers are biological markers that help to detect status of health or disease. Biosensors' applications are for screening for early detection, chronic disease treatment, health management, and well-being surveillance. Smart devices that allow continual monitoring of vital biomarkers for physiological health monitoring, medical diagnosis, and assessment are becoming increasingly widespread in a variety of applications, ranging from biomedical to healthcare systems of surveillance and monitoring. The term "smart" is used due to the ability of these devices to extract data with intelligence and in real time. Wearable, implantable, ingestible, and portable devices can all be considered smart devices; this is due to their ability of smart interpretation of data, through their smart sensors or biosensors and indicators. Wearable and portable devices have progressed more and more in the shape of various accessories, integrated clothes, and body attachments and inserts. Moreover, implantable and ingestible devices allow for the medical diagnosis and treatment of patients using tiny sensors and biomedical gadgets or devices have become available, thus increasing the quality and efficacy of medical treatments by a significant margin. This article summarizes the state of the art in portable, wearable, ingestible, and implantable devices for health status monitoring and disease management and their possible applications. It also identifies some new technologies that have the potential to contribute to the development of personalized care. Further, these devices are non-invasive in nature, providing information with accuracy and in given time, thus making these devices important for the future use of humanity.

Pioneer Role of Extracellular Vesicles as Modulators of Cancer Initiation in Progression, Drug Therapy, and Vaccine Prospects.

Cancer is one of the leading diseases, causing deaths worldwide. Nearly 10 million deaths were reported in 2020 due to cancer alone. Several factors are involved in cancer progressions, such as lifestyle and genetic characteristics. According to a recent report, extracellular vesicles (EVs) are involved in cancer initiation, progression, and therapy failure. EVs can play a major role in intracellular communication, the maintenance of tissue homeostasis, and pathogenesis in several types of diseases. In a healthy person, EVs carry different cargoes, such as miRNA, lncRNA etc., to help other body functions. On the other hand, the same EV in a tumor microenvironment carries cargoes such as miRNA, lncRNA, etc., to initiate or help cancer progression at various stages. These stages may include the proliferation of cells and escape from apoptosis, angiogenesis, cell invasion, and metastasis, reprogramming energy metabolism, evasion of the immune response, and transfer of mutations. Tumor-derived EVs manipulate by altering normal functions of the body and affect the epigenetics of normal cells by limiting the genetic makeup through transferring mutations, histone modifications, etc. Tumor-derived EVs also pose therapy resistance through transferring drug efflux pumps and posing multiple drug resistances. Such EVs can also help as biomarkers for different cancer types and stages, which ultimately help with cancer diagnosis at early stages. In this review, we will shed light on EVs' role in performing normal functions of the body and their position in different hallmarks of cancer, in altering the genetics of a normal cell in a tumor microenvironment, and their role in therapy resistance, as well as the importance of EVs as diagnostic tools.

Dynamic gain aperture modelocking in picosecond regime based on cascaded second-order nonlinearity.

The operation of a cascaded second-order mode-locked Nd:YVO4 laser has been investigated considering it as a soft-aperture Kerr lens type and using complex beam parameters. A self consistent complex beam propagation method is used to incorporate the effect of cascaded Kerr nonlinearity on radially varying gain aperturing. The analysis deduces a stable pulsewidth of ~9.5 ps which agrees well with the experimental value of 10.3 ps.

Single rolled-up InGaAs/GaAs quantum dot microtubes integrated with silicon-on-insulator waveguides.

We report on single rolled-up microtubes integrated with silicon-on-insulator waveguides. Microtubes with diameters of ~7 µm, wall thicknesses of ~250 nm, and lengths greater than 100 µm are fabricated by selectively releasing a coherently strained InGaAs/GaAs quantum dot layer from the handling GaAs substrate. The microtubes are then transferred from their host substrate to silicon-on-insulator waveguides by an optical fiber abrupt taper. The Q-factor of the waveguide coupled microtube is measured to be 1.5×10(5), the highest recorded for a semiconductor microtube cavity to date. The insertion loss and extinction ratio of the microtube are 1 dB and 34 dB respectively. By pumping the microtube with a 635 nm laser, the resonance wavelength is shifted by 0.7 nm. The integration of InGaAs/GaAs microtubes with silicon-on-insulator waveguides provides a simple, low loss, high extinction passive filter solution in the C+L band communication regime.