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1.
Bispecific antibody takes a BiTE out of B cells in rheumatoid arthritis.
Mullard, Asher.
Nat Rev Drug Discov ; 2024 May 13.
Article in English | MEDLINE | ID: mdl-38740966
2.
CXCR4 chemokine antagonist scores a first FDA approval for WHIM syndrome.
Mullard, Asher.
Nat Rev Drug Discov ; 2024 May 13.
Article in English | MEDLINE | ID: mdl-38740965
3.
Experimental obesity drug packs double punch to reduce weight.
Mullard, Asher.
Nature ; 629(8013): 733-734, 2024 May.
Article in English | MEDLINE | ID: mdl-38750205

Subject(s)
Anti-Obesity Agents , Obesity , Obesity/prevention & control , Obesity/drug therapy , Humans , Anti-Obesity Agents/pharmacology , Animals , Weight Loss/drug effects , Mice
4.
RNA-rewriting candidate moves into the clinic.
Mullard, Asher.
Nat Rev Drug Discov ; 2024 May 20.
Article in English | MEDLINE | ID: mdl-38769406
5.
First-in-class IL-15 receptor agonist nabs FDA approval for bladder cancer.
Mullard, Asher.
Nat Rev Drug Discov ; 2024 Apr 26.
Article in English | MEDLINE | ID: mdl-38671056
6.
FDA approves first complement factor D inhibitor.
Mullard, Asher.
Nat Rev Drug Discov ; 23(5): 329, 2024 May.
Article in English | MEDLINE | ID: mdl-38605116

Subject(s)
Drug Approval , United States Food and Drug Administration , Humans , United States
7.
FDA approves an HDAC inhibitor for Duchenne muscular dystrophy.
Mullard, Asher.
Nat Rev Drug Discov ; 23(5): 329, 2024 May.
Article in English | MEDLINE | ID: mdl-38605117

Subject(s)
Drug Approval , Histone Deacetylase Inhibitors , Muscular Dystrophy, Duchenne , United States Food and Drug Administration , Muscular Dystrophy, Duchenne/drug therapy , Humans , Histone Deacetylase Inhibitors/therapeutic use , Histone Deacetylase Inhibitors/pharmacology , United States
8.
Three-step cures for autoimmune diseases?
Mullard, Asher.
Nat Rev Drug Discov ; 23(5): 332-333, 2024 May.
Article in English | MEDLINE | ID: mdl-38632392

Subject(s)
Autoimmune Diseases , Humans , Autoimmune Diseases/drug therapy , Autoimmune Diseases/immunology , Autoimmune Diseases/therapy
9.
RNA-editing drugs advance into clinical trials.
Mullard, Asher.
Nat Rev Drug Discov ; 23(5): 323-326, 2024 May.
Article in English | MEDLINE | ID: mdl-38637628

Subject(s)
Clinical Trials as Topic , Humans , RNA Editing , Drug Development/methods
10.
GSK's first-in-class antibiotic secures another phase III win, approaches regulatory run.
Mullard, Asher.
Nat Rev Drug Discov ; 23(4): 239, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38459351

Subject(s)
Influenza, Human , Humans
11.
Shifts in the clinical trial landscape.
Mullard, Asher.
Nat Rev Drug Discov ; 23(4): 239, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38459352
12.
From basic research to budding biotechs, under one roof with Stuart Schreiber.
Mullard, Asher.
Nat Rev Drug Discov ; 23(4): 244-245, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38429526

Subject(s)
Biotechnology , Research , Humans
13.
FDA approves gene therapy for metachromatic leukodystrophy, the tenth for a genetic disease and the priciest yet.
Mullard, Asher.
Nat Rev Drug Discov ; 23(5): 328, 2024 May.
Article in English | MEDLINE | ID: mdl-38548889

Subject(s)
Genetic Therapy , Leukodystrophy, Metachromatic , United States Food and Drug Administration , Humans , United States , Genetic Therapy/methods , Leukodystrophy, Metachromatic/genetics , Leukodystrophy, Metachromatic/therapy , Drug Approval
14.
Novartis bets US$2.9 billion on MorphoSys and an anti-myelofibrosis drug.
Mullard, Asher.
Nat Rev Drug Discov ; 23(3): 162, 2024 03.
Article in English | MEDLINE | ID: mdl-38347156
15.
Sanofi buys Inhibrx and drug for alpha-1 antitrypsin deficiency for US$1.7 billion.
Mullard, Asher.
Nat Rev Drug Discov ; 23(3): 163, 2024 03.
Article in English | MEDLINE | ID: mdl-38347157

Subject(s)
alpha 1-Antitrypsin Deficiency , Humans , alpha 1-Antitrypsin Deficiency/drug therapy
16.
Vertex's non-opioid painkiller passes phase III tests.
Mullard, Asher.
Nat Rev Drug Discov ; 23(3): 162, 2024 03.
Article in English | MEDLINE | ID: mdl-38347158
17.
When can AI deliver the drug discovery hits?
Mullard, Asher.
Nat Rev Drug Discov ; 23(3): 159-161, 2024 03.
Article in English | MEDLINE | ID: mdl-38374252

Subject(s)
Artificial Intelligence , Drug Discovery , Humans
18.
FDA approves first tumour-infiltrating lymphocyte (TIL) therapy, bolstering hopes for cell therapies in solid cancers.
Mullard, Asher.
Nat Rev Drug Discov ; 23(4): 238, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38374249

Subject(s)
Lymphocytes, Tumor-Infiltrating , Neoplasms , Humans , Immunotherapy, Adoptive , Interleukin-2 , Neoplasms/drug therapy
19.
CAR-T therapy for multiple sclerosis enters US trials for first time.
Mullard, Asher.
Nature ; 2024 Feb 22.
Article in English | MEDLINE | ID: mdl-38396094
20.
Turbocharged CAR-T cells melt tumours in mice - using a trick from cancer cells.
Mullard, Asher.
Nature ; 2024 Feb 07.
Article in English | MEDLINE | ID: mdl-38326423
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