ABSTRACT
Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2) affects various human organ systems, including the lymphatic, pulmonary, gastrointestinal, and neurologic systems. The utilization of osteopathic manipulative treatment (OMT) techniques has been clinically effective in the alleviation of various upper respiratory infection symptoms. Consequently, the use of osteopathic manipulative medicine (OMM) in SARS-CoV-2 patients as adjunct treatment can be beneficial in promoting overall recovery. This paper attempts to address the pathophysiology of SARS-CoV-2 infection at the cellular level and its downstream effects. Subsequently, osteopathic principles were investigated to evaluate potential therapeutic effects, providing a holistic approach in the SARS-CoV-2 treatment. Although the association between the benefits of OMT on clinical improvement during the 1918 Spanish influenza pandemic can be seen, further investigation is required to establish a direct correlation between OMT and symptom management in SARS-CoV-2.
Subject(s)
COVID-19 , Influenza, Human , Manipulation, Osteopathic , Osteopathic Medicine , Humans , Manipulation, Osteopathic/methods , SARS-CoV-2 , COVID-19/epidemiology , COVID-19/therapyABSTRACT
Recognizing that its research may raise various ethical, social, and philosophical issues, the HBP has made the identification, examination, and management of those issues a top priority. The Ethics and Society subproject is part of the core research project.
Subject(s)
Brain/physiology , Neurosciences/ethics , Social Responsibility , European Union , Humans , Neurosciences/organization & administration , Neurosciences/standardsABSTRACT
We present a first-draft digital reconstruction of the microcircuitry of somatosensory cortex of juvenile rat. The reconstruction uses cellular and synaptic organizing principles to algorithmically reconstruct detailed anatomy and physiology from sparse experimental data. An objective anatomical method defines a neocortical volume of 0.29 ± 0.01 mm(3) containing ~31,000 neurons, and patch-clamp studies identify 55 layer-specific morphological and 207 morpho-electrical neuron subtypes. When digitally reconstructed neurons are positioned in the volume and synapse formation is restricted to biological bouton densities and numbers of synapses per connection, their overlapping arbors form ~8 million connections with ~37 million synapses. Simulations reproduce an array of in vitro and in vivo experiments without parameter tuning. Additionally, we find a spectrum of network states with a sharp transition from synchronous to asynchronous activity, modulated by physiological mechanisms. The spectrum of network states, dynamically reconfigured around this transition, supports diverse information processing strategies. PAPERCLIP: VIDEO ABSTRACT.
Subject(s)
Computer Simulation , Models, Neurological , Neocortex/cytology , Neurons/classification , Neurons/cytology , Somatosensory Cortex/cytology , Algorithms , Animals , Hindlimb/innervation , Male , Neocortex/physiology , Nerve Net , Neurons/physiology , Rats , Rats, Wistar , Somatosensory Cortex/physiologySubject(s)
Cooperative Behavior , Information Systems , Neocortex , Somatosensory Cortex , Animals , RatsABSTRACT
The present manuscript reviewed studies investigating biases and deficits in memory and attention related to Obsessive-Compulsive Disorder (OCD). Although the research has been mixed concerning memory for verbal information, there is more consistent evidence suggesting impairment for non-verbal information, particularly for complex visual stimuli and the individual's own actions. Further, a number of studies indicate that patients with OCD report less confidence in their judgments about recognition memory. Finally, OCD appears to be associated with an attentional bias favoring threatening information, as well as reduced levels of cognitive inhibition. The manuscript concludes with a number of recommendations for future research.
