ABSTRACT
We have determined the immunograms and the titers of anti-influenza antibody in the cord serum of 112 newborns. The immunologic parameters have been correlated with signs of adaptation in the immediate neonatal period. The immunograms showed an increase of the values of IgG and the presence of IgM and IgA in the cord serum, at levels according with the increase of the titer of anti-influenza antibodies. The presence of IgM and IgA in the cord serum at high levels is the expression of an active process of antibody synthesis in these foetuses as the consequence of an intrauterine infection. In our study, maternal influenza was implicated in the stimulation of the foetus immune system and in the alteration of neonatal adaptation.
Subject(s)
Adaptation, Physiological , Fetal Blood/immunology , Antibodies, Viral/analysis , Humans , Immunoglobulin A/analysis , Immunoglobulin M/analysis , Infant, Newborn , Influenza A virus/immunology , SeasonsABSTRACT
We have studied the tonus of the tracheal muscle (tracheal spiral) gathered from guinea pig and kept in Tyrode solution at 38 degrees C, continuously oxygenated. Tonus variations were recorded by a tension transducer on an xy recorder. After administration of histamine (H) in the organ bathroom, we observed an increase of tonus, with large spontaneous movements of the tracheal muscle. Blocking the beta-adrenergic receptors with propranolol (Pr) suppressed the effect of adrenaline (Adr) but did not influence the effects of II and acetylcholine (Ach) The reaction to II was more diminished in the presence of fosfobion (ATP) in the organ bathroom.