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Biosci Biotechnol Biochem ; 88(2): 203-205, 2024 Jan 24.
Article in English | MEDLINE | ID: mdl-37947260

ABSTRACT

Licking behavior with various salts in transmembrane channel-like 4 (Tmc4) knockout (KO) mice was observed. In Tmc4 KO mice, a significant decrease in sensitivity to chloride salts, such as NaCl, KCl, and NH4Cl, was observed, while no significant decrease in sensitivity to Na-gluconate was observed. This finding suggests that TMC4 may be involved in the detection of chloride taste.


Subject(s)
Chlorides , Salts , Animals , Mice , Amiloride , Mice, Knockout , Potassium Chloride/pharmacology , Taste
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