ABSTRACT
A 47-year-old, non-smoking woman was admitted to the National Tuberculosis and Lung Diseases Research Institute for diagnosis of progressive exertional dyspnoea and numerous small thin-walled, air-filled cysts equally distributed throughout both lungs revealed in HRCT (high resolution computed tomography) examination. Histological assessment of specimens obtained by open lung biopsy revealed proliferation of immature smooth muscle, showing the expression of the antigen HMB45. On this basis, diagnosis of lymphangioleiomyomatosis was established. The disease caused essential ventilation damage of the lungs (FEV1 1.34 L; 39.71% pred, VC 4.02 L; 94.96% pred, FEV1/ /VC 0.33-4 1.81% pred, DLCO 3.65 mmol/min/Kpa 38.35% pred).During the observation, despite the lack of immunological disorders, the patient developed Pneumocystis jiroveci pneumonia (PCP) that was treated with trimethoprimsulfamethoxazole. Lymphangioleiomyomatosis is a rare disease which results from a defect of TSC genes. The disease is not related to immunological defects or disorders. However, the considerable cystic destruction of the lungs can predispose the patient to opportunistic infections such as the one in the presented case.
Subject(s)
Lung Neoplasms/complications , Lung Neoplasms/diagnosis , Lymphangioleiomyomatosis/complications , Lymphangioleiomyomatosis/diagnosis , Pneumonia, Pneumocystis/complications , Pneumonia, Pneumocystis/diagnosis , Anti-Infective Agents/therapeutic use , Female , Humans , Lung Neoplasms/drug therapy , Lymphangioleiomyomatosis/drug therapy , Middle Aged , Pneumonia, Pneumocystis/drug therapy , Treatment Outcome , Trimethoprim, Sulfamethoxazole Drug Combination/administration & dosageABSTRACT
A 72-year-old patient with a rare disease-exogenous lipoid pneumonia (ELP) was described. One year ago he underwent laryngectomy because of larynx carcinoma and now he was admitted to hospital because of suspicion of cancer progression in the lungs. Chest HRCT and microscopic picture of BALF suggested diagnosis of lipoid pneumonia. His history supported it because he used oil drops to hist tracheostomy outline.
