ABSTRACT
Paragangliomas, or glomus tumors, are neoplasms arising from extra-adrenal chromaffin tissue. They frequently cause symptoms by over-production of catecholamines with known predilection to multicentricity. We describe the case of a patient with bilateral carotid body tumor who underwent a preoperative 68Gallium labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-Octreotide (68Ga-DOTANOC) positron emission tomography/computed tomography (PET/CT) imaging for staging. This is a unique case in which multiple paraganglioma and pheochromocytoma were demonstrated in a single patient using 68Ga-DOTANOC PET/CT (AU)
Los paragangliomas o tumores de glomus son tumores derivados del tejido cromafín extraadrenal y con frecuencia causan síntomas por exceso de producción de catecolaminas con conocida predilección a ser multicéntricas. Se describe a un paciente con un tumor del cuerpo carotídeo bilateral al que se realizó un estudio PET/TC de extensión preoperatorio con 68Ga-DOTANOC. Este es un caso único en el que al mismo paciente se le diagnosticó un paraganglioma múltiple y un feocromocitoma con 68Ga-DOTANOC PET/TC (AU)
Subject(s)
Humans , Male , Middle Aged , Preoperative Period , Somatostatin/therapeutic use , Receptors, Somatostatin/analysis , Positron-Emission Tomography/methods , Positron-Emission Tomography/standards , Positron-Emission Tomography , Paraganglioma/complications , Paraganglioma , Positron-Emission Tomography/trends , Head and Neck Neoplasms , Carotid Body/pathology , Carotid Body , Carotid Body TumorABSTRACT
Paragangliomas, or glomus tumors, are neoplasms arising from extra-adrenal chromaffin tissue. They frequently cause symptoms by over-production of catecholamines with known predilection to multicentricity. We describe the case of a patient with bilateral carotid body tumor who underwent a preoperative 68Gallium labeled [1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid]-1-NaI3-Octreotide (68Ga-DOTANOC) positron emission tomography/computed tomography (PET/CT) imaging for staging. This is a unique case in which multiple paraganglioma and pheochromocytoma were demonstrated in a single patient using 68Ga-DOTANOC PET/CT.
Subject(s)
Adrenal Gland Neoplasms/diagnostic imaging , Carotid Body Tumor/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging , Organometallic Compounds/analysis , Paraganglioma/diagnostic imaging , Pheochromocytoma/diagnostic imaging , Positron Emission Tomography Computed Tomography , Radiopharmaceuticals/analysis , Abdominal Neoplasms/chemistry , Abdominal Neoplasms/diagnostic imaging , Adrenal Gland Neoplasms/chemistry , Carotid Body Tumor/chemistry , Humans , Magnetic Resonance Imaging , Male , Mediastinal Neoplasms/chemistry , Mediastinal Neoplasms/diagnostic imaging , Middle Aged , Multimodal Imaging , Neoplasm Proteins/analysis , Neoplasms, Multiple Primary/chemistry , Paraganglioma/chemistry , Pheochromocytoma/chemistry , Preoperative Care , Receptors, Somatostatin/analysis , Sensitivity and Specificity , Whole Body ImagingABSTRACT
OBJECTIVE: The purpose of the present study was to evaluate the role of 68-gallium-1,4,7,10-tetraazacyclododecane-1,4,7,10-tetraacetic acid-1-Nal3-octreotide ((68)Ga-DOTA-NOC) positron emission tomography CT (PET-CT) in carotid body chemodectomas (CBCs). METHODS: 5 patients with known CBCs (conventional imaging and angiography) were evaluated retrospectively (3 males, 2 females; mean age 36.6 years). All underwent PET-CT after injection of 148 MBq (4 mCi) of (68)Ga-DOTA-NOC. RESULTS: At baseline there were four bilateral CBCs and one unilateral CBC with an additional glomus tympanicum and bilateral glomus jugulare tumour in these five patients. All these lesions showed intense uptake on (68)Ga-DOTA-NOC PET-CT. Apart from these known lesions, additional tumours were detected in three patients; glomus jugulare in one, aortic body tumour and multiple abdominal paragangliomas in another and unsuspected vertebral metastasis in the last. Overall it led to a change in management in 3 of the 5 patients (60%). CONCLUSION: (68)Ga-DOTA-NOC PET-CT is a promising non-invasive imaging modality in the detection and characterisation of CBCs.