ABSTRACT
OBJECTIVES: Purpose of this study is to evaluate the clinical significance of major aortopulmonary collateral arteries (MAPCAs) during the early postoperative course after arterial switch operation (ASO) in d-transposition of the great arteries (dTGA). METHODS: Clinical data of 98 patients with simple dTGA between January 2007 and December 2016 at the University Children's Hospital Zurich, Switzerland were analyzed retrospectively. RESULTS: 37 from 98 patients (38%) required cardiac catheterization (CC) due to an early complicated postoperative course or difficult coronary transfer due to special coronary anatomy. In 15 (15%) patients, hemodynamically relevant MAPCAs were found during CC and coil embolization was performed. Patients with relevant MAPCAs had a significantly longer PICU stay (7 versus 6â¯days, pâ¯=â¯0.021), longer hospital stay (41 versus 27â¯days, pâ¯=â¯0.005), longer mechanical ventilation time (5 versus 3â¯days, pâ¯=â¯0.005), longer need for inotropic support (5 versus 4â¯days, pâ¯=â¯0.001) and delayed chest closure time (3 versus 2â¯days, pâ¯=â¯0.030) in those in whom it was left open in comparison to all other patients. In patients having CC, pre-surgery oxygen saturation was significantly lower in patients with relevant MAPCAs (58% vs 70%, p 0.019). Echocardiography had a sensitivity of 53% and a specificity of 100% in detecting relevant MAPCAs, accurately. CONCLUSIONS: MAPCAs are frequently found in dTGA patients and can be associated with lower baseline oxygen saturation and a prolonged postoperative course after ASO. Transthoracic echocardiography cannot replace CC as diagnostic tool. If significant MAPCAs are suspected, early CC should be performed for diagnostic and therapeutic reasons.
Subject(s)
Arterial Switch Operation/trends , Collateral Circulation , Postoperative Complications/diagnostic imaging , Pulmonary Artery/diagnostic imaging , Transposition of Great Vessels/diagnostic imaging , Transposition of Great Vessels/surgery , Aortic Coarctation/diagnostic imaging , Aortic Coarctation/etiology , Arterial Switch Operation/adverse effects , Cohort Studies , Collateral Circulation/physiology , Female , Humans , Infant , Infant, Newborn , Male , Postoperative Complications/etiology , Pulmonary Artery/physiology , Retrospective StudiesABSTRACT
Hypothermia is being studied as a neuroprotective therapy after asphyxia. This report is about a term newborn with severe asphyxia who underwent systemic hypothermia (34.5 degrees C) for 72 h. He survived without apparent brain damage but developed sclerema on his back, in the area in contact with the cooling mattress. The sclerema resolved without scarring after three months.