ABSTRACT
We report the case of a 66-year-old female with a history of type-2 diabetes and dyslipidemia, who presented due to episodes of vomiting, epigastric discomfort and weight loss. Impaired liver function prompted a biopsy, which revealed the presence of non-necrotizing granulomas. Tomography showed hypodense bands and atrophic areas at the peripheral parenchyma. Magnetic resonance imaging showed predominantly perivascular inflammatory bands.
Subject(s)
Liver Diseases , Sarcoidosis , Aged , Female , Granuloma , Humans , Liver Cirrhosis/complications , Liver Cirrhosis/diagnostic imaging , Liver Diseases/pathology , Magnetic Resonance Imaging/methods , Sarcoidosis/complications , Sarcoidosis/diagnostic imagingABSTRACT
Objetivo. Comparar la supervivencia del cáncer de mama en mujeres que han sido cribadas en el programa de Detección Precoz del Cáncer de Mama (DPCM) y en las que no han participado en él. Pacientes y métodos. Es un estudio descriptivo y longitudinal en el que se han estudiado todos los cánceres de mama registrados en el servicio de Anatomía Patológica del Hospital de Tortosa Verge de la Cinta (Tarragona) de mujeres de 50-65 años, que se habían detectado la enfermedad ellas mismas o que la había detectado el programa DPCM, desde junio de 1999 hasta junio de 2003. Se registraron 101 pacientes con cáncer de mama, de las que en 84 se pudieron recoger todos los datos relativos al tumor, la cirugía y el tratamiento. En el 2014, tras un seguimiento de 11,6 ± 1,8 años, se anotó el estado actual. Resultados. No hay diferencia estadísticamente significativa en la supervivencia de los 2 grupos. Pacientes con carcinoma in situ y sin ganglios metastásicos se encuentran entre las fallecidas, mientras que ninguna paciente con carcinoma bien diferenciado falleció. Conclusiones. En nuestro estudio, el cribado del cáncer de mama no mejora la supervivencia y determinados factores en los que se apoyan los programas de cribado, como la detección de carcinomas no infiltrantes y/o de ganglios no metastásicos, no aseguran la curación (AU)
Objective. To compare survival in breast cancer between women diagnosed in an early breast cancer detection programme and those not attending this programme. Patients and methods. We conducted a descriptive and longitudinal study that analysed all types of breast cancer registered in the Pathology Service of the Hospital de Tortosa Verge de la Cinta (Tarragona, Spain). Tumour samples were obtained from 50-65-year-old women who had detected alterations on self-examination and from those attending the early breast cancer detection programme from June 1999 to June 2003. All the information relating to the tumour, surgery or treatment was registered. In 2014, after a follow-up of 11.6 ± 1.8 years, the current status of each patient was recorded. Results. There was no significant statistical difference in survival between the two groups of patients. Non-survivors included patients with in situ carcinoma and without lymph node metastases. Survival was 100% in patients with well differentiated carcinoma. Conclusions. Breast cancer screening did not improve survival in our study. The elements on which screening programs are based, such as non-invasive carcinoma detection and/or non- metastatic lymph nodes, do not ensure recovery (AU)
Subject(s)
Humans , Female , Adult , Breast Neoplasms/metabolism , Breast Neoplasms/pathology , Mass Screening/classification , Mass Screening/methods , Lymph Nodes/metabolism , Spain/ethnology , Sentinel Lymph Node Biopsy/methods , Breast Neoplasms/drug therapy , Breast Neoplasms/therapy , Disease-Free Survival , Mass Screening/standards , Mass Screening , Lymph Nodes/abnormalities , Sentinel Lymph Node Biopsy/standardsABSTRACT
No disponible
Subject(s)
Humans , Male , Aged , Carcinoma, Squamous Cell/diagnosis , Esophageal Neoplasms/diagnosis , Skin Neoplasms/secondary , Neoplasm MetastasisABSTRACT
La asociación del lupus eritematoso sistémico (LES) y la enfermedad inflamatoria intestinal es rara. Presentamos el caso de una mujer de 24 años con LES que comenzó con dolor abdominal y diarrea. No había datos de exacerbación de LES. Las pruebas complementarias mostraron hallazgos típicos de enfermedad de Crohn (AU)
A 24-year-old woman with systemic lupus erythematosus (SLE) presented abdominal pain and diarrhea. No evidence for an SLE flare was obtained. Colonoscopy and microscopic biopsy examination revealed findings typical of Crohn's disease. Despite the rarity of the combination, patients with SLE showing gastrointestinal manifestations might merit evaluation for Crohn disease (AU)
Subject(s)
Humans , Female , Adult , Lupus Erythematosus, Systemic/complications , Lupus Erythematosus, Systemic/diagnosis , Crohn Disease/complications , Abdominal Pain/etiology , Diarrhea/complications , Cyclophosphamide/therapeutic use , Prednisone/therapeutic use , Azathioprine/therapeutic use , Mesalamine/therapeutic use , Pancreatitis/complications , Lupus Erythematosus, Systemic/physiopathology , Crohn Disease/physiopathology , Diarrhea/diagnosis , Pancreatitis/drug therapy , Crohn Disease/diagnosis , Abdominal Pain/complications , /methods , Colonoscopy/methods , ColonoscopyABSTRACT
A 24-year-old woman with systemic lupus erythematosus (SLE) presented abdominal pain and diarrhea. No evidence for an SLE flare was obtained. Colonoscopy and microscopic biopsy examination revealed findings typical of Crohn's disease. Despite the rarity of the combination, patients with SLE showing gastrointestinal manifestations might merit evaluation for Crohn disease.
Subject(s)
Crohn Disease/diagnosis , Lupus Erythematosus, Systemic/complications , Adult , Crohn Disease/complications , Female , HumansABSTRACT
La esclerodermia localizada es una enfermedad del tejido conectivo generalmente limitada a la piel y tejido celular subcutáneo; sin embargo; puede progresar a grandes placas induradas, retraso del crecimiento, atrofia muscular e incluso deformidades en flexión o pobre cicatrización de las heridas. La morfea generalizada unilateral es una variante rara de la esclerodermia localizada descrita ocasionalmente en la literatura. Presentamos el caso de una niña con morfea generalizada unilateral que afectó al lado derecho del cuerpo (AU)
Localized scleroderma is a connective tissue disorder generally involving de entire dermis and usually limited to the subcutaneous tissue; however, it may progress to large indurated plaques, growth retardation, muscle atrophy, and even to flexion deformities or poorly healing ulcers. Unilateral generalized morphea is an extremely rare variant of localized scleroderma which has seldom been reported in the literature. We report the case of a girl who developed unilateral generalized morphea on the right side of the body (AU)
Subject(s)
Humans , Male , Adult , Arthritis, Rheumatoid/complications , Arthritis, Rheumatoid/drug therapy , Antibodies, Monoclonal , Guillain-Barre Syndrome/complications , Tumor Necrosis Factor-alpha/administration & dosage , Tumor Necrosis Factor-alpha , Methotrexate/therapeutic use , Ceftriaxone/therapeutic use , Vancomycin/therapeutic use , Electromyography/methods , Electromyography , Meningitis, Bacterial/complications , Antibodies, Monoclonal/adverse effects , Ampicillin/therapeutic use , Immunoglobulins/therapeutic use , Hydrocortisone/therapeutic useABSTRACT
Localized scleroderma is a connective tissue disorder generally involving de entire dermis and usually limited to the subcutaneous tissue; however, it may progress to large indurated plaques, growth retardation, muscle atrophy, and even to flexion deformities or poorly healing ulcers. Unilateral generalized morphea is an extremely rare variant of localized scleroderma which has seldom been reported in the literature. We report the case of a girl who developed unilateral generalized morphea on the right side of the body.