ABSTRACT
Pharmacokinetic parameters of norethisterone (NET) were studied in eight adult male bonnet monkeys following the administration of a single dose of 300 ug. The animals were crossed over between the following three routes of administration: oral ingestion, nasal and sublingual spraying. The results indicate that NET was readily absorbed by all three routes but the Cmax and AUC of NET were significantly greater by the sublingual route. No significant difference in the t 1/2 alpha or t 1/2 beta was observed between the three routes. These findings suggest that the sublingual route offers the possibility of reducing the effective dose of NET, which is widely used for contraceptive purposes.
Subject(s)
Norethindrone/blood , Administration, Intranasal , Administration, Oral , Animals , Kinetics , Macaca radiata , Male , Norethindrone/administration & dosage , TongueABSTRACT
A simple colorimetric method is described for the determination of terbutaline sulfate. The method is based on measurement of a colored species formed when terbutaline sulfate is treated with diazotized dapsone and p-nitroaniline at room temperature. Compounds such as starch, talc, and common excipients do not interfere in the reaction. Statistical validation showed that the method was highly precise and accurate. The results agree well with those obtained by other methods reported in the literature.
Subject(s)
Terbutaline/analysis , Aniline Compounds/analysis , Colorimetry , Dapsone/analysis , Solutions , TabletsABSTRACT
A simple extractive photometric method for the determination of tetramisole hydrochloride in pharmaceutical preparations is described. The method uses the formation of coloured complexes of the drug with reagents such as Solochrome Dark Blue, Solochrome Black T, Bromocresol Purple, Bromothymol Blue, Bromophenol Blue and Bromocresol Green in an acidic buffer. The ion-pair complexes formed are quantitatively extracted into chloroform under the experimental conditions.
ABSTRACT
A simple spectrophotometric method for the determination of nylidrin hydrochloride, isoxsuprine hydrochloride and salbutamol sulphate is described, based on measurement of the orangeyellow species produced when the drugs are coupled with diazotized benzocaine (p-aminoethyl benzoate) in trimethylamine medium. The method is applicable over the range 1-12 mug ml for isoxsuprine hydrochloride and nylidrin hydrochloride and 1-8 mug ml for salbutamol sulphate. The method is a modification of the Bratton-Marshall reaction and is simple, reproducible, accurate and more sensitive than those cited in the literature.
