Seroprevalence of Epstein-Barr virus, hepatitis B virus, hepatitis C virus, and human immunodeficiency virus among patients with non-Hodgkin's lymphoma at the Yaounde General Hospital, Cameroon.

The non-Hodgkin's lymphomas (NHLs) are a diverse group of malignancies that originate in lymphoid cells, heterogeneous in clinical behavior, morphology, cellular origin, etiology, and pathogenesis. A viral infectious etiology had been associated with them. This study aimed to investigate the seroprevalence of Epstein-Barr virus (EBV), Hepatitis B virus (HBV), Hepatitis C virus (HCV) and Human Immunodeficiency Virus (HIV) among patients with NHL at the Yaoundé General Hospital (YGH). Participants for this cross-sectional study were recruited at the medical oncology unit from October 2018 to December 2019. For each patient fulfilling the inclusion criteria, five milliliters of blood were drawn at the crook of their elbows in EDTA tubes. Then, EBV, HIV, HBV, and HVC screening were done using the Rapid Diagnostic Tests (RDTs); Bio-Rad EBV, Alere Determine HIV-1/HIV-2, HBV the best diagnostic and HVC Wondfo biotech respectively. Participants were made up of sixty-three males (69.23%) and twenty-eight females (30.77%). Their ages ranged from nineteen to seventy-eight years, with a mean ± SD of 56.5 ± 15.5. There were eight HIV patients (8.8%) followed by five EBV or HBV patients (5.5%). Three patients were coinfected with HIV+EBV (3.3%) while only two patients (2.2%) had HCV. Only HIV and EBV were seen coinfected. The presence of HBV and HCV in patients with NHL reveals the need to understand how these viruses induce lymphoproliferative diseases, more precisely, the non-Hodgkin´s lymphoma.

In vitro antitubercular activity of extract and constituents from the stem bark of Disthemonanthus benthamianus

ABSTRACT A new C-glycosylflavone, apigenin 7-methyl ether 6-C-[β-xylopyranosyl-(1→3)-β-glucopyranoside] named distemonanthoside was isolated from the stem bark of Distemonanthus benthamianus Baill., Fabaceae, along with six known compounds, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid, syringic acid, quercetin, 6"-O-acetylvitexin, quercetin 3-O-β-D-glucopyranoside. The structures of those compounds and others were determined through spectral analyses. Compounds distemonanthoside, sitosterol 3-O-β-D-glucopyranoside, 4-methoxygallic acid and quercetin were tested against a clinical isolate strain of Mycobacterium tuberculosis AC 45; they exhibited good to moderate antitubercular activities with MIC values ranged from 31.25 to 125 µg/ml.