Where the Rubber Meets the Road - Research in the Amazon.

Antimalarial Research in the AmazonMany patients who receive treatment for vivax malaria in the Americas present with recurrent infection within six months after completing treatment. This raises an important question: Does higher-dose primaquine work better than the treatment currently used in the Americas to prevent recurrences? This Clinical Trial Case Study describes the behind-the-scenes story of a randomized trial to evaluate antimalarial treatment efficacy in the Brazilian Amazon.