[Different therapeutic approaches for chronic diffuse liver lesions using ornicetil, lactulose, etimizol and corinfar]. / Dyferentsiiovani pidkhody do likuvannia khronichnykh dyfuznykh urazhen' pechinky iz zastosuvanniam ornitsetylu, laktulozy, etymizolu ta korynfaru.

Different therapeutic regimens were tried in 67 patients with hepatic cirrhosis and in 54 patients with chronic hepatitis depending on the leading pathological syndrome. Treatment schemes involved the use of the drug ornicetil in patients having acute episodes of portal systemic encephalopacy, lactulose in those presenting with an increased content of ammonia in the blood and symptoms of chronic portal systemic encephalopacy; etimizol was given to those patients with an apperant antioxidant imbalance. Differentiated approaches to the institution of curative measures permitted improving considerably the patients' medical rehabilitation, achieving regression of pathological manifestations. It has been found out that the above drugs exert a positive effect on the cytolytic and mesenchimal-inflammatory syndromes and will, we believe, come to be widely used for treating diffuse lesions of the liver.

[Use of pentoxifylline in the treatment of systemic scleroderma]. / Zastosuvannia pentoksyfilinu v likuvanni systemnoï sklerodermiï.

Analyzes in the paper are chief pharmacological effects of pentoxifylline; the necessity is substantiated of its prescription in a combined therapy of systemic scleroderma (SSD). As many as 220 SSD patients on an in-patient care were examined. Apart from general clinical, biochemical, immunological methods of investigation, the condition of the microcirculation system was studied, the level of the tumor necrosis serumal factor alfa (TNF-alpha) was measured. The data secured suggest a considerable increase in the level of TNF-alpha and pronounced disturbances in microcirculation. The administration of pentoxifylline to SSD patients has been found to improve the microcirculation and reduce the production of the above factor, which fact suggests its immunomodulating properties.

[Role of interleukin-1 and interleukin-2 in the pathogenesis of systemic scleroderma]. / Interleikin-1 ta interleikin-2 u patohenezi systemnoï sklerodermiï.

The purpose of a research was to define the levels of interleukin-1 (IL-1) and interleukin-2 (IL-2) in patients with systemic scleroderma (SSc) and to analyse their dependence on the course of the illness. 75 patients with SSc and 20 apparently healthy people were examined. Besides the well-known clinical-biochemical and instrumental investigations, the levels of IL-1 and Il-2 in all the patients were determined in serum with an immunoenzymatic method using a set of reactants Pro Con IL-1b and Pro Con IL-2 (Russia). The data obtained give evidence for an increase in both IL-1 and IL-2 levels. As the correlation between the level of IL-1 and the acuteness of the pathological process has been shown to be especially distinct, it can be used for marking an acute form of this pathology. Thus, both parametres (IL-1, IL-2) depend on the acuity and peculiarities of SSc, and on the concomitant damage of the internal organs. The most pronounced increase in LL-2 level has been observed at visceralisation of SSc.

[Osteocalcin--a marker of bone metabolism in rheumatoid arthritis patients]. / Osteokal'tsyn--marker kistkovoho metabolizmu u khvorykh na revmatoïdnyi artryt.

Blood serum concentration of osteocalcin was studied in 53 patients with rheumatoid arthritis. Osteocalcin (noncollagenous protein of bony tissue) is a marker of bony tissue formation known to be of high informative value. There were no significant differences in values for osteocalcin concentration between patients with rheumatoid arthritis and healthy people. Reduction of osteocalcin content and, correspondingly, of process of bony tissue formation was observed in rapidly progressing course of rheumatoid arthritis and in stage IV arthritis. Rises in osteocalcin concentration were recordable in those women in there postmenopause. Patients with rheumatoid arthritis were found out to experience adequate formation of bony tissue in spite of the osteopenia syndrome progression. Disordered structural and functional state of the bony tissue processes of remodelling may be explained by bony tissue remodeling processes dissociation.

[The complex assessment of the consequences of anthropogenic environmental pollution and the principles for their prevention]. / Kompleksna ostinka mutahennykh naslidkiv antropohennoho zabrudnennia dovkillia i pryntsypy ïkh profilaktyki.

Genetic monitoring on the basis of clinical-epidemiologic indices of congenital and hereditary pathology among newborns and spontaneous abortions as well as morphogenetic finding analysis in different age group representatives have been carried out. Mutation process dynamics in various ecological zone populations has been established. Dermatoglyphics and karyograme changes have been revealed their expressiveness depended on the general state of the organism, age and hereditary predisposition to polygenic diseases.

[The morbidity indices of subjects with incorporated radioactive iodine]. / Pokaznyky zakhvoriuvanosti u osib z inkorporovanym radioaktyvnym iodom.

With the purpose of detecting long-term somatic effects of incorporated iodine, an analysis was performed of health disorders in those subjects (n = 1040) who received 131 I in therapeutic dosages 25 to 30 years ago. Discordances in pituitary-thyroid- and pituitary-adrenal axes were found to result in excessive metabolic-degenerative and vegetovascular type morbidity rates compared with the general population. Mortality index exceeds that of in the population 2.1-fold. No one of the deceased had reached the average length of human life. Halt the cases died of ischemic heart disease, 6 patients developed carcinoma of endocrine organs; these were all females, who had taken radioactive iodine prior to the age of 30 years. Thus, in remote time periods after incorporation, there develop a number of those disorders leading ultimately to reduction of the length of human life, which is believed to be one of the universal effects of irradiation.

[The dynamics of the glycocholic acid content of the bile in patients with chronic inactive hepatitis]. / Dynamika vmistu hlikokholevoï kysloty v zhovchi khvorykh na khronichnyi neaktyvnyi hepatyt.

The studies made showed the content of bile acids in the bile, in particular that of glycocholic one, to get moderately reduced in chronic inactive hepatitis, which fact is thought to bring about dyspeptic events showing up in the above conditions: changeable stools, periodic moderate abdominal distention, nausea and other manifestations. It has been shown that the hepatic cells functional capacity may be medically controlled. Combined use in a therapeutic complex of riboxin and ricavit resulted in normalization of the glycocholic acid content in the patients' bile. Riboxin and ricavit used separately in the therapeutic programme proved to be ineffective as a treatment option.

[Enteroinsular hormones in chronic gastritis with secretory insufficiency]. / Enteroinsuliarni hormony pry khronichnomu hastryti z sekretornoiu nedostatnistiu.

The blood serum content of secretin, vasointestinal peptide (VIP), glucagon and insulin was studied in 112 patients with chronic gastritis presenting with secretory deficiency, and 12 essentially healthy subjects. It was established that in surface, fundal and pangastritis the levels of secretin and VIP did not differ from the values in healthy individuals. The secretin concentration tended to be the lowest in atrophic fundal and atrophic pangastritis. They also had significantly elevated concentrations of VIP and glucagon, with insulin decreased. Caused by different exo- and endogenous factors phenomena characteristic of gastritis, such as disturbances in acid-producing function of the stomach, to mention but one of its manifestations, result in changes of stimulatory effects of acidification on enterinic elements of the small intestine, which circumstance leads to discoordination in output of intestinal and pancreatic hormones particularly pronounced in atrophic gastritis.

[The effect of etimizol on the glycosaminoglycan level in patients with osteoarthrosis deformans]. / Vplyv etymizolu na riven' hlikozaminohlikaniv u khvorykh na deformuiuchyi osteoartroz.

Aetymizolum was studied for its efficacy in the treatment of patients with osteoarthrosis. The results obtained suggest that aethymizolum is capable of correcting the levels of glycosaminoglucans in the patients' blood serum. With the content of the latter being dependent upon the degree of the articular cartilage destruction in osteoarthrosis deformans, it is suggested that aethymizolum while being endowed with reparative and membrane stabilizing properties may at the same time influence the articular cartilage metabolism and decrease the intensity of the destruction of the later. Effect of aethymizolum is more pronounced in mono-oligoarthrosis and polyosteoarthrosis as well as in stages II and III of the disease course. Conventional therapies (indomethacin, humisolum, Fibs, physiotherapeutic procedures, remedial gymnastics, massage) have no effect on these parameters.

[The clofelin and nifedipine treatment of hypertensive crises in elderly patients]. / Likuvannia hipertonichnykh kryziv u khvorykh pokhyloho viku klofelinom i nifedypinom.

Simultaneous use of clophelin and nifedipine for hypertensive attacks in elderly subjects resulted in a sharp fall of the AP due to decrease of the cardiac ejection. In consecutive use of these drugs nifedipine was followed 2 hours later by clophelin in small dosterinemia and increase of cardiac ejection were observed. The consecutive method is ses and a prolonged reduction of AP, peripheral resistance, diastolic values, hyperaldo- preferred in the elderly patients.

[The level of total immunoglobulin E in the blood serum of rheumatism patients]. / Riven' zahal'noho imunohlobulinu klasu E v syrovattsi krovi khvorykh na revmatyzm.

The mean level of total IgE in the sera of patients with active rheumatism was significantly higher than during non-active phase of the disease and in healthy blood donors. The highest level of hyper-IgE-emia is observed in the continuously relapsing variant of rheumatism. Increased content of total serum IgE in active rheumatism is observed both in manifest and in latent variants of the disease. Articular and cerebral manifestations of rheumatism are not, apparently, related to the IgE level. The serum IgE may be a supplementary diagnostic criterion of rheumatic activity, especially with advance of the cardiovascular insufficiency.