Gestational Diabetes Mellitus, Obstetric Data, and Simple Congenital Ptosis.

PURPOSE: This retrospective cohort study aimed to identify obstetric risk factors for simple congenital ptosis and propose an underlying pathophysiological mechanism. METHODS: Newborns diagnosed with simple congenital ptosis (n = 51) were compared with existing population data in terms of obstetric parameters. RESULTS: Positive associations were found between simple congenital ptosis and gestational diabetes mellitus (11.8% vs. 5%, p = 0.026), preterm delivery (15.7% vs. 0.05%, p < 0.001), and lower birth weight (2,998 ± 506 vs. 3,255 ± 484, p < 0.001). CONCLUSIONS: This study pioneers an association between simple congenital ptosis and gestational diabetes mellitus, potentially linked to insulin-like growth factor 1 levels. We advocate for early ophthalmology checkups for specific newborn subsets.

Factors associated with changes in posterior corneal surface following laser-assisted in situ keratomileusis.

PURPOSE: To identify factors associated with changes in the posterior corneal curvature following laser-assisted in situ keratomileusis (LASIK). METHODS: This retrospective study included myopic astigmatic eyes that underwent LASIK between January and December 2013 at Care-Vision Laser Center, Tel-Aviv, Israel. The average posterior keratometry was measured with the Sirius device at a radius of 3 mm from the center. The correlations between the surgically induced change in average posterior keratometry and preoperative parameters such as preoperative sphere, cylinder, spherical equivalent, central corneal thickness (CCT), refraction, Baiocchi Calossi Versaci (BCV) index, ablation depth, percent of tissue altered (PTA), and residual stromal bed (RSB) are reported. RESULTS: A total of 115 eyes with a mean age of 32.5 ± 8.3 years (range 22-56 years) were included. Central corneal thickness (p < 0.005), preoperative sphere (p < 0.001), spherical equivalent (p < 0.005), and preoperative posterior inferior/superior ratio (p < 0.05) were all significantly correlated with the percentage of change in the mean posterior K. According to ranked stepwise multiple regression analysis, 22% of the variance of change in posterior K could be explained by the examined factors. The factors that remained significant were the percentage of change in posterior inferior/superior ratio, preoperative subjective sphere, and preoperative mean posterior K (for all, p < 0.001). CONCLUSIONS: The percentage of change in posterior inferior/superior ratio, subjective sphere, and preoperative mean posterior K are all correlated with change in the mean posterior K after LASIK. Understanding of the variables that can influence posterior corneal changes following refractive surgery may play a role in the prevention of iatrogenic keratectasia.

Should Multifocal Intraocular Lenses Become a Standard in Phacoemulsification Cataract Surgery?

Cataracts impair daily activities such as reading, outdoor sports, and driving, which may not match best-corrected visual acuity at optimal room light conditions, but can be just as important to patients [...].

Changes in chorioretinal flow index after cataract surgery: an optical coherence tomography angiography study.

PURPOSE: Pseudophakic cystoid macular edema (CME) occurs in up to 2% of uneventful cataract surgeries. This study evaluates changes in macular blood flow succeeding uneventful phacoemulsification cataract extraction among otherwise visually healthy subjects. METHODS: This prospective study included 18 eyes of 18 patients undergoing routine phacoemulsification. Optical coherence tomography angiography (OCT-A) was performed using the Angio-Retina 6 × 6 mm protocol with the XR Avanti Angio-Vue system (Optovue Inc., Fremont, California) prior to the surgery and 4-8 weeks thereafter. Exclusion criteria included motion artifacts, segmentation errors and signal strength index (SSI) < 40. The main outcome measure was change in flow index (FI) measured in all 4 retinal segmentation layers within an area of 1 mm diameter around the foveal center. RESULTS: Following surgery, a significant increase in SSI (46.65 ± 8.62 versus 53.12 ± 8.07, p = 0.01), superficial plexus FI (0.98 ± 0.23 versus 1.16 ± 0.16, p = 0.02) and deep plexus FI (0.54 ± 0.46 versus 0.93 ± 0.39, p = 0.01) was found. No significant changes were noted in the outer retina or the choriocapillaris. CONCLUSION: The study demonstrates a significant increase in FI in the superficial and deep retinal plexus following uneventful cataract surgery, with the greatest changes occurring in the latter. These findings corroborate evidence from structural imaging and support the vascular etiology of pseudophakic CME.

Long-term outcomes of anti-vascular endothelial growth factor treatment in peripapillary choroidal neovascularisation due to age-related macular degeneration.

OBJECTIVE: To report the long-term outcomes of anti-vascular endothelial growth factor (VEGF) treatment in eyes with peripapillary choroidal neovascularisation (PPCNV) associated with age-related macular degeneration (AMD). METHODS: A retrospective cohort study included patients with AMD-related PPCNV. Eyes were treated with anti-VEGF according to pro re nata regimen. Inactivation index was calculated as the proportion of disease inactivity from the total follow up time. RESULTS: Sixty-seven eyes of 66 consecutive patients were included in the study; mean follow-up time was 53.2 months. Best corrected visual acuity (BCVA) remained stable for the first four years of follow up, with a significant deterioration in BCVA thereafter. Baseline BCVA was a significant predictor of final BCVA (p < 0.001). The mean inactivation index was 0.38 ± 0.23. Subretinal fluid (SRF) at presentation was significantly associated with decreased inactivation index (p < 0.05). Worse baseline BCVA, SRF and pigment epithelium detachment (PED), male sex, and younger patient age were associated with increased risk for recurrence after first inactivation (p < 0.05). CONCLUSION: The use of anti-VEGF agents in the treatment of AMD-related PPCNV managed to preserve BCVA in the first four years of follow-up. Male sex, SRF and PED at presentation and baseline BCVA are associated with increased risk for PPCNV recurrence after the first inactivation, and should prompt careful follow-up in these patients.

The Effect of Meibomian Gland Dysfunction on Laser-Assisted In Situ Keratomileusis in Asymptomatic Patients.

INTRODUCTION: To evaluate the impact of asymptomatic meibomian gland dysfunction (MGD) on laser-assisted in situ keratomileusis (LASIK) outcomes and dry eye signs and symptoms. METHODS: A retrospective analysis of patients who underwent LASIK surgery between July 2017 and February 2018 at Care Vision Refractive Clinic, Tel Aviv, Israel, was done. Patients were divided into those who had preoperative asymptomatic significant MGD (MGD group) and those who did not have preoperative significant MGD (control group). Outcomes were the postoperative presence of punctate epithelial erosions, dry eye symptoms, the number of postoperative visits as a measure of adverse events, visual acuity, spherical equivalent, safety index, efficacy index, and the type of refractive error (myopia or hyperopia). RESULTS: A total of 497 eyes were included in this study. Both groups had similar rates of punctate epithelial erosions, 30 (12.9%) patients vs. 39 patients (14.8%) (p = 0.31); postoperative complaints of dryness, 75 patients (32.3%) vs. 90 patients (34.2%) (p = 0.36); and postoperative number of visits, 3.15 ± 0.75 vs. 3.12 ± 0.54 (p = 0.59). Uncorrected visual acuity (logMAR) at 1 month (0.026 ± 0.09 vs. 0.026 ± 0.17, p = 0.99) after surgery was similar in both groups. Mean spherical equivalent was 0.03 ± 0.17 and - 0.03 ± 0.18 (p = 0.99) in both groups. Safety index was 1.024 ± 0.06 in the clinically significant MGD group and 1.029 ± 0.07 in the control group (p = 0.45). Efficacy index was also similar in both groups (0.966 ± 0.155 and 0.979 ± 0.14, respectively, p = 0.31). No differences were found between patients with myopia and hyperopia. CONCLUSIONS: Patients with preoperative asymptomatic MGD have similar LASIK outcomes to patients without preoperative asymptomatic MGD. Accordingly, no preoperative MGD treatment or special caution is needed in these cases.

Functional and Structural Findings in Infants Treated for Retinopathy of Prematurity Using Optical Coherence Tomography Angiography.

BACKGROUND AND OBJECTIVE: To assess the foveal microvascular structure of children with retinopathy of prematurity (ROP) treated with diode laser photocoagulation using optical coherence tomography angiography (OCTA). PATIENTS AND METHODS: OCTA was performed at a tertiary medical center in 17 children (27 eyes) aged 4 to 16 years with a history of diode laser photocoagulation treated ROP. OCTA parameters were compared with those of 12 healthy age-matched controls (23 eyes) attending the orthoptics clinic and correlated with clinical factors. RESULTS: Compared with controls, the ROP group had a smaller foveal avascular zone area (P < .001), lower deep vascular plexus density (P < .001), lower flow density (P = .025), and greater central macular thickness (P < .001). High intraventricular hemorrhage grade correlated with smaller foveal avascular zone area (P = .008) and greater inner macular thickness (P = .047). There was no impact of gestational age, birth weight, or refractive status. CONCLUSION: OCTA can identify significant quantifiable long-term macular microvascular and structural changes in this patient population. [Ophthalmic Surg Lasers Imaging Retina. 2022;53(4):194-201.].

Outcomes of Congenital Nasolacrimal Duct Obstruction Surgery Converted into Balloon Dilation and Silicone Intubation due to Probing Difficulty.

Background: To report the outcomes of balloon catheter dilatation and silicone intubation as a sequential secondary surgery under the same anesthesia, a stepwise approach for congenital nasolacrimal duct obstruction (NLDO) when probing and irrigation as primary procedure fails. Methods: A retrospective study included children with NLDO who underwent probing and irrigation only, and those who underwent in the same surgery under anesthesia, adjunct balloon catheter dilation and silicone intubation due to difficulty of the probe passage or fluid regurgitation from the punctum. The primary outcome was surgical success defined as resolution of preoperative symptoms and signs at 1 month. Results: A total of 105 NLDO cases were included. Eighty-four cases underwent probing and irrigation only, whereas 21 cases required balloon dilation and silicone intubation consecutively after the first procedure. Patient age at surgery was higher for those requiring balloon dilatation and intubation (30.3 ± 8.0 months) when compared to those with probing and irrigation only (22.4 ± 10.3 months, p < 0.001). The onset of symptoms, preoperative clinical findings regarding tearing and discharge and gender distribution of patients were comparable between the two groups. During the follow-up, the overall success rate for probing and irrigation only was 76.2% (64 out of 84 cases) and for balloon dilatation and silicone tube intubation was 90.5% (19 out of 21 cases). Conclusions: The surgical team may prepare to proceed with secondary surgery under the same anesthesia after the initial attempt of probing and irrigation. This stepwise two-stage approach in patients with congenital NLDO failing primary surgery resulted in a high success rate with minimal interventions, avoiding repeated general anesthesia.

FULL-THICKNESS MACULAR HOLE IN AGE-RELATED MACULAR DEGENERATION PATIENTS WITH TWO DISTINCT ENTITIES: A Multicenter Study.

PURPOSE: To describe optical coherence tomography characteristics of full-thickness macular holes (FTMHs) in age-related macular degeneration patients. METHODS: A multicenter, retrospective, observational case series of patients diagnosed with age-related macular degeneration and FTMHs seen between January 1, 2009, and January 3, 2020. Clinical charts and spectral-domain optical coherence tomography images were reviewed. Optical coherence tomography findings included FTMH-inverted trapezoid or hourglass appearance, central macular thickness (CMT), complete retinal pigment epithelium and complete retinal outer retinal atrophy, and presence of pigment epithelium detachment and epiretinal membrane. The mean outcome was the morphologic and functional characterization of different subtypes of FTMHs. RESULTS: A total of 86 eyes of 85 consecutive patients, with mean age of 80.31 ± 8.06 and mean best-corrected visual acuity of 1.17 ± 0.58 logarithm of the minimal angle of resolution. Two different subtypes of FTMHs were identified: tractional and degenerative. Fifty (58%) degenerative FTMHs characterized with inverted trapezoid appearance and 36 (42%) tractional FTMHs characterized with hourglass appearance. Degenerative FTMHs presented with 66% of CMT < 240 µm, 14% of CMT > 320, and 70% of complete retinal outer retinal atrophy, in comparison with 41% of CMT < 240 µm, 42.9% of CMT > 320%, and 20% of complete retinal outer retinal atrophy in the tractional FTMH group (P = 0.002, 0.003, <0.001, respectively). The presence of epiretinal membrane and pigment epithelium detachment where significantly higher in tractional FTMHs (P = 0.02, 0.03, respectively). CONCLUSION: Degenerative and tractional FTMHs may be two distinct clinical entities. Discerning degenerative from tractional FTMHs is possible by using optical coherence tomography features including shape of the FTMHs, CMT, internal-external ratio of FTMHs, and presence of complete retinal outer retinal atrophy, pigment epithelium detachment, and epiretinal membrane.

Factors associated with changes in posterior corneal surface following photorefractive keratectomy.

PURPOSE: To identify factors associated with changes in the posterior cornea curvature following laser refractive surgery. MATERIALS AND METHODS: This retrospective study included myopic astigmatic eyes that underwent PRK between January 2013 and December 2013 at Care-Vision Laser Centers, Tel-Aviv, Israel. The average posterior K was measured with the Sirius device at a radius of 3 mm from the center. The correlations between the surgical induced change in average posterior k and preoperative parameters such as central corneal thickness (CCT), refraction, Baiocchi Calossi Versaci index (BCV), ablation depth, percent tissue altered (PTA), and residual stroma bed (RSB) were analyzed. RESULTS: A total of 280 eyes with a mean age of 24.9 ± 6.1 years (range, 18-47 years were included in this study. The mean PTA was 14.8 ± 6.0%. A greater change in posterior K was found in females (p = 0.01), smaller treatment zones of 6.0 mm (p = 0.02) and PTA > 20% (p < 0.001). A lower CCT (r = - 0.24, p < 0.001), higher myopia (r = - 0.34, p < 0.001), higher astigmatism (r = - 0.17, p < 0.001), higher total BCV (r = 0.13, p = 0.03), lower back BCV (r = - 0.12, p = 0.05), higher front BCV (r = 0.16, p = 0.01), higher posterior I-S ratio (r = 0.16, p = 0.01), and a lower RSB (r = - 0.42, p < 0.001) were all significantly correlated with percentage of change in mean posterior K. In ranked stepwise multiple regression analysis, 26.2% of the variance of change in posterior K could be explained by the examined factors. The factors that remained significant were PTA (p < 0.001), CCT (p = 0.001), and posterior I-S ratio (p = 0.001). PTA alone accounted for 15% of the variance in posterior K changes in multivariate analysis. CONCLUSIONS: Understanding of factors affecting a change in posterior cornea after refractive surgery may have an important practical value for the prevention of iatrogenic keratectasia. Preoperative CCT, posterior I-S ratio, and PTA were significantly associated with changes in posterior K after PRK. PTA was the strongest predictor of posterior corneal changes (p < 0.001).

Centration of myopic refractive ablation: should we center treatment on the pupil or the visual axis?

The purpose of this study is to compare pupil versus corneal vertex-centered ablation for myopic laser refractive surgery. This study is a retrospective case series of right eyes of consecutive myopic patients undergoing either photorefractive keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK) with pupil or corneal vertex-centered ablation from January 2018 to April 2018. Overall 258 eyes of 258 patients were included. Of the 104 that underwent LASIK, 52 were treated centered on the corneal vertex (50%), and of the 154 that underwent PRK, 77 were treated centered on the corneal vertex (50%). There were no significant differences in baseline age, gender, spherical equivalence, sphere, cylinder, or angle kappa between both groups in either LASIK or PRK. There were no significant differences between the corneal vertex-centered and pupil-centered groups in terms of efficacy index (LASIK: 1.02 ± 0.14 vs 1.01 ± 0.13, p = 0.86; PRK: 1.00 ± 0.13 vs 0.99 ± 0.15, p = 0.61), safety index (LASIK: 1.02 ± 0.12 vs 1.01 ± 0.13, p = 0.70; PRK:1.02 ± 0.12 vs 1.02 ± 0.09, p = 0.97), and residual astigmatism (LASIK: 0.26 ± 0.25 vs 0.23 ± 0.28, p = 0.65; PRK:0.37 ± 0.41 vs 0.39 ± 0.31, p = 0.78). In mixed effect models, there were no significant differences between the corneal vertex-centered and pupil-centered groups when accounting for angle kappa (p > 0.05). Patients with large angle kappa (> 300 µm) eyes yielded similar results (p > 0.05). For conclusion, in myopic refractive surgery, performing ablation centered on the corneal vertex or on the pupil leads to similar outcomes regardless of the amount of angle kappa.

Outcomes of photorefractive keratectomy in patients with posterior corneal steepening.

PURPOSE: To assess post-operative outcomes following photorefractive keratectomy (PRK) in patients with posterior corneal steepening compared to an age, gender and refraction matched control group. METHODS: A retrospective matched case-control study that analysed outcomes of PRK in eyes with posterior corneal steepening as shown by the Sirius tomography (Sirius, CSO, Italy), versus normal eyes. Both groups were age, gender and refraction matched. Data collected include: demographic data, pre-operative and post-operative refraction, uncorrected distance visual acuity (UDVA) and corrected distance visual acuity (CDVA), maximal ablation depth. Inferior-superior ratio, central corneal thickness (CCT), mean posterior keratometry (K), Baiocchi Calossi Versaci index for the front (BCVf) and back (BCVb) cornea, the symmetry index of front (SIf) and back (SIb) corneal curvature were assessed pre- and postoperatively. RESULTS: Overall, 89 study eyes and 954 normal myopic eyes were included. Compared to the control group, corneas with posterior steepening demonstrated significantly reduced CDVA (p < 0.0001 and p = 0.007) and lower CCT (p < 0.0001 and p = 0.03), before and following the operation, respectively. Pre-operative BCVf, BCVb, SIf and SIb were significantly higher in corneas with posterior steepening (p < 0.0001) and remained higher following the surgery except for BCVf. Ectasia occurred in one eye (1.1%). The safety and efficacy indices at 12 months were comparable for both groups. CONCLUSION: PRK on corneas with posterior steepening results in similar refractive outcomes compared to normal eyes, 1 year following the surgery. Keratectasia is a rare, however a possible complication.

Risk factors for early flap misalignment following microkeratome-assisted laser in situ keratomileusis: A retrospective large database analysis.

PURPOSE: To determine factors associated with early flap misalignment following microkeratome-assisted laser in situ keratomileusis. MATERIALS AND METHODS: This retrospective study included the right eyes of consecutive patients who underwent laser in situ keratomileusis procedure between 2005 and 2016 at Care-Vision Laser Centers, Tel-Aviv, Israel. Patients were divided into two groups according to whether or not they subsequently developed early flap misalignment. RESULTS: A total of 14,582 eyes (mean age of patients: 32.4 ± 10.3 years) were included. Post-laser in situ keratomileusis early flap misalignment developed in 158 eyes (1.1%). Misalignment was more frequent during the spring (32.3% vs 22.8%, p = 0.003) and in a higher operating room temperature (23.34 ± 1.06 vs 22.98 ± 1.26, p < 0.001). In addition, in the misalignment group, there was a higher rate with the of use of the a Moria M2 microkeratome (rather than sub-Bowman's keratomileusis microkeratome) head (55.2% vs 40.5%, respectively, p < 0.001). In a multivariable analysis adjusted for surgeon and year of surgery, high operating room temperature (odds ratio = 1.22, p = 0.006), treatment zone of 9.0 mm (as opposed to smaller treatment zones, odds ratio = 1.54, p = 0.04), and springtime (odds ratio = 1.58, p = 0.02) were associated with flap misalignment. There was a significant difference in misalignment rates between surgeons (p = 0.02). CONCLUSION: This study found that larger treatment zones, higher operating room temperature, operating during the spring, and the use of Moria M2 microkeratome were associated with increased flap misalignment rates. The association with operating room temperature and seasonal variation is of interest and merits further research.

Conjunctivodacryocystorhinostomy (CDCR) success rates and complications in endoscopic vs non-endoscopic approaches: a systematic review.

BACKGROUND: Epiphora due to refractory bicanalicular obstructions is typically managed by conjunctivodacryocystorhinostomy (CDCR) with or without the assistance of nasal endoscopy. However, the evidence for its benefit is unclear. METHODS: A systematic review of the literature on the treatment of epiphora by CDCR was performed (March 1, 2018). All studies reporting original data on patients suffering from epiphora treated with CDCR surgery were included. Primary outcomes were success and satisfaction rates. Secondary outcomes were CDCR complications. A comparison was made between the results obtained in patients undergoing CDCR with vs without assistance of nasal endoscopy. RESULTS: Fifty-four studies representing information on 2555 CDCR procedures were included in the systematic review. All the studies are case series, most of them retrospective. Lester Jones tube (LJT) is the most commonly used in CDCR (66.7%). The overall success rate with all studies included (n = 2555) was 88.9%; 90.8% (n = 890) in CDCR with assistance of nasal endoscope and 87.7% (n = 1575) in the non-endoscopic approach. The overall "tube displacement" rate, the most common complication, was 24.5% (n = 2522), 20.8% (n = 1575) tube displacement in CDCR with assistance of nasal endoscope vs 26.7% (n = 1575) in the non-endoscopic approach. Only 3 studies (5.5%) used patient-reported outcome measures (PROMs) to evaluate epiphora improvement. Due to the low level of evidence and the high bias of the studies, a meta-analysis was not performed. CONCLUSION: Based on the data available in the literature, CDCR is considered an effective procedure for treating epiphora due to proximal obstruction. Controlled and qualitative studies are needed to clarify the significance of the endoscope's contribution to CDCR.

Post laser-assisted in-situ keratomileusis dry eye disease and temporary punctal plugs.

PURPOSE: The aim of this study was to compare the incidence of post laser in situ keratomileusis (LASIK) dry eye with and without intraoperative extended duration temporary punctal plug placement. METHODS: This retrospective study included myopicastigmatic eyes without a preoperative diagnosis of dry eye disease that underwent LASIK surgery between January 2017, and March 2018. Patients who received punctal plugs during surgery in addition to usual postoperative care were compared to a control group who received usual postoperative care alone. Visual acuity, safety and efficacy indices, as well as predictability and presence of dry eye disease were assessed 3-6 months after surgery. RESULTS: A total of 345 eyes of 345 patients were included, 172 eyes received punctal plugs and 173 did not. The mean age was 30.4 ± 10 years (range: 17-60 years) and 46.1% (N = 159) were female. Both groups were similar in terms of preoperative parameters, including age, gender, spherical equivalent, pachymetry or contact lens use. Patients treated with punctal plugs had significantly less postoperative dry eye complaints (N = 37 vs. 58, 21.5% vs. 34.1% respectively, P = 0.001). Patients treated with plugs that did develop dry eye disease did so later (51.2 ± 77.64 days' vs. 20.78 ± 26.9 days, P = 0.009). Postoperative visual acuities were similar between groups (P > 0.05) at all postoperative follow-up visits as were safety (0.95 ± 0.16 vs. 0.99 ± 0.09, P = 0.30) and efficacy (1.01 ± 0.13 vs. 1.00 ± 0.11, P = 0.52) indices. CONCLUSION: Preventative temporary punctal plug placement during LASIK appears to reduce dry eye disease in the short term, without affecting visual acuity outcomes.

Hyperopic laser keratorefractive surgery: Do steep corneas have worse outcomes?

PURPOSE: To report the visual and refractive outcomes of hyperopic patients undergoing laser keratorefractive surgery in preoperatively steep corneas versus a matched control group. METHODS: Retrospective cohort study. All patients underwent photorefractive keratectomy (PRK) or laser-assisted in situ keratomileusis (LASIK) at Care-Vision Laser Centers, Tel-Aviv, Israel, between 1/2000 and 11/2016. Patients were divided into two groups: steep corneas (mean keratometry ≥ 44.00 D) and control group (mean keratometry < 44.00 D). The two study groups were matched by age, gender, sphere and cylinder. Only the right eye of each patient was included. Outcomes included postoperative uncorrected distance visual acuity (UDVA), best-corrected distance visual acuity (CDVA), safety and efficacy indexes, refractive outcomes and retreatment rates. RESULTS: Five hundred and two patients were included. Both groups were similar in demographic data, visual acuity and refraction. Postoperatively, the steep corneas group had a significantly higher mean keratometry as compared to the control group (46.52 ± 1.43 D vs 44.58 ± 1.68 D, p < 0.001), Kmin (46.04 ± 1.50 D vs 44.12 ± 1.76 D, p < 0.001) and Kmax (46.99 ± 1.51 D vs 45.03 ± 1.77 D, p < 0.001). Both groups had similar postoperative UDVA and CDVA and achieved a similar final sphere (0.64 ± 0.19 vs 0.54 ± 1.19, p = 0.44) and cylinder (- 0.89 ± 0.59 vs - 0.86 ± 0.72, p = 0.67). Both groups had a similar efficacy index (0.92 ± 0.22 vs 0.90 ± 0.25, p = 0.33) and similar retreatment rates (4.2% vs 3.5%, p = 0.74). None of the patients in either group underwent more than one retreatment throughout the follow-up period. CONCLUSIONS: Hyperopic patients with steep corneas undergoing laser keratorefractive surgery can achieve adequate visual and refractive outcomes, similar to control group.

Sino-nasal outcome test-22: Cross-cultural adaptation and validation in Russian speaking patients.

BACKGROUND: Chronic rhinosinusitis (CRS) is a relatively common disease, which significantly affects the patient's quality of life (QoL). Sino-Nasal Outcome Test-22 (SNOT-22) is a QoL questionnaire, which allows quantifying patients' complaints. Our aim was to translate and validated the SNOT-22 into the Russian language. METHODS: Translation and validation of SNOT-22 questionnaire was performed through forward-backward translation technique. After proper translation, the translated questionnaire was completed by CRS patients before and after endoscopic sinus surgery (ESS) and by healthy individuals as controls. RESULTS: Thirty-four native Russian-speaking CRS patients completed the Russian version of the SNOT-22 questionnaire before and after ESS. The internal consistency for reliability assessment was very good (mean Cronbach's alpha = 0.816 for CRS patients). Mean scores for the preoperative, postoperative and control groups were 67.6, 18.1 and 9.2, respectively (P < .001), showing validity and responsiveness of the questionnaire. CONCLUSION: The Russian version of the SNOT-22 questionnaire is a valid outcome measure for patients with CRS.