Autism spectrum disorder and new perspectives on the reliability of second to fourth digit ratio.

The second to fourth digit ratio (2D:4D) is according to previous studies a likely biomarker for prenatal testosterone exposure and its effect on the human brain. It was found to be linked to autism spectrum disorders (ASD). Recently, 2D:4D raised a lot of questions with regard to its stability and autism-related behaviors. Here, we present a cross-sectional study of 2D:4D in boys (N = 91, mean age 7.63) and adults (N = 36 mean age 22.8) with ASD as well as neurotypical students, 506 participants in total. Digit ratio was assessed by taking measurements from digital scans, compared between groups and correlated with the autism quotient. Significant differences were found in the digit ratio of children and adults. Both girls and boys had 2D:4D ratio lower than women and men, both on the right (p = 0.000 in females, p = 0.000 in males) and left hand (p = 0.018 in females, p = 0.011 in males). No significant differences were found in digit ratios between neurotypical subjects and those with ASD nor was there a relationship with the reported autistic traits, which leads us to question the reliability of 2D:4D and its relation to ASD.

Estimation of stature and body weight in Slovak adults using static footprints: A preliminary study.

The stature and the body weight as part of the biological profile can aid the personal identification. The dimensions of the human foot, as well as the footprint, can be used for the prediction due to the existence of its positive correlation with the stature and body weight. Five diagonal axes and ball breadth of bilateral static footprints of 132 young Slovak adults were obtained. All diameters were larger in a male group than female group. No bilateral differences were found except the first diagonal axis and ball breadth. A positive correlations between the selected footprint diameters with the stature (r = 0.37-0.64) and the body weight (r = 0.29-0.71) were confirmed. The linear and multiple regression prediction equations were developed. A stature prediction equation using the most lateral diameters (the fourth and fifth diagonal axis) exhibited the highest accuracy ranging from 4 to 7.5 cm. Similar results were found for the body weight estimation of the male and mixed group. In the female group, the most medial axis (first and second) exhibited the highest accuracy. The body weight estimation accuracy ranges from 9.09 to 11.09 kg. The real and predicted stature and body weight were compared and found differences were lower than calculated SEEs. Thresholds and prediction trend of under- or overestimation was identified. The results of the present study show that selected measurements of static footprints could be used to predict stature and body weight but should be applied only for Slovaks due to population specificity.

Metrical evaluation of Slovak patients with pectus excavatum.

PURPOSE: We have started to assess the severity of pectus excavatum by means of anthropometric methods prior to CT examination since 2012. The aim of the study was to establish a significance of anthropometry as first-line diagnostic method. Afterwards, we analyzed statistical significance of differences in selected anthropometric indicators before and after surgical intervention. The analysis was also focused on the data from CT scans. METHODS: The followed group represented 27 patients, including 6 girls and 21 boys aged 7-18 years (mean age 15.59 years). Evaluation of anthropometric measurements was realized by somatometry, and other metrical measurements were calculated from thoracic CT scans of patients. All measurements were managed with the approval of the Ethics Committee. RESULTS: The significant differences were found in sagittal diameter and thoracic index in 64.0 % of the patients. Data analyzed from CT showed that flat chest prevailed in both gender (100 %). The largest group represented asymmetric type of pectus excavatum (40.74 %). The superiority of the asymmetric type to the right was confirmed. The values of the Haller index were in range 2.00-5.17 (mean value 3.64). 81.5 % of patients met criterion for surgical correction. Most patients with pectus excavatum had a milder form of deformation. CONCLUSIONS: Anthropometry provides feasible and non-invasive method of pectus deformities evaluation. Based on the study results, anthropometry should be performed prior to CT examination in order to select patients for surgical treatment. Anthropometric measurements are helpful in accurate documentation of growth, longitudinal observation of the patient, and can support decision concerning the type of surgery.

Anthropometry of craniosynostosis.

BACKGROUND: Anthropometry is becoming a popular method for diagnostics of various diseases in pediatric clinical practice. The aim of this study was to assess the growth changes in craniofacial parameters in patients with craniosynostosis and positional plagiocephaly. METHODS: Inclusion criteria for the study were presence of craniostenosis or positional plagiocephaly in a patient with at least three anthropometric evaluations at our department. Studied patients were aged from 1.0 month to 2.5 years with median age at the first and last anthropometric evaluation as 1.83 and 25.27 months, respectively. Further anthropometric results in patients older than 2.5 years were excluded from the study. Statistical significance was tested by the Mann-Whitney test. RESULTS: The studied group consisted of 70.5% male patients. The type of craniosynostosis was represented by scaphocephaly in 44.1%, by trigonocephaly in 45.6% and by coronal craniosynostosis in 10.3% of the cases. Cranial index was proven as a suitable parameter for evaluating differences in the trend of growth in craniosynostosis (p<0.001) and also for evaluating post-operative results. Significance was found in width of the head (p=0.038) for scaphocephaly and in length of the head for trigonocephaly (p=0.001) in surgically treated patients. Trend of cranial growth in operated patients copied the curve of the norm but in higher or lower values which depends on the type of prematurely closed suture. CONCLUSION: Longitudinal anthropometric follow-up is an objective and measurable method that can accurately non-invasively and non-expensively assess skull growth in pediatric patients with cranial deformity.

Estimation of stature using hand and foot dimensions in Slovak adults.

Hand and foot dimensions used for stature estimation help to formulate a biological profile in the process of personal identification. Morphological variability of hands and feet shows the importance of generating population-specific equations to estimate stature. The stature, hand length, hand breadth, foot length and foot breadth of 250 young Slovak males and females, aged 18-24 years, were measured according to standard anthropometric procedures. The data were statistically analyzed using independent t-test for sex and bilateral differences. Pearson correlation coefficient was used for assessing relationship between stature and hand/foot parameters, and subsequently linear regression analysis was used to estimate stature. The results revealed significant sex differences in hand and foot dimensions as well as in stature (p<0.05). There was a positive and statistically significant correlation between stature and all measurements in both sexes (p<0.01). The highest correlation coefficient was found for foot length in males (r=0.71) as well as in females (r=0.63). Regression equations were computed separately for each sex. The accuracy of stature prediction ranged from ±4.6 to ±6.1cm. The results of this study indicate that hand and foot dimension can be used to estimate stature for Slovak for the purpose of forensic field. The regression equations can be of use for stature estimation particularly in cases of dismembered bodies.

Nutrition and immune system: the size of the thymus as an indicator of the newborn's nutrition status.

SUMMARY: The thymus is a central lymphatic organ reaching its largest size after the delivery. Its size is significantly affected by endogenous and exogenous negative factors. In our research, we investigated the relationship between the size of the thymus determined by sonography and anthropometric parameters as well as indexes demonstrating the nutritional status. The examined group consisted of 212 full-term newborns, all of which passed an anthropometric examination during the first five days after delivery (birth weight and length, mid-arm and head circumference). The following nutritional status indexes were calculated from estimated anthropometric dimensions: Quételet's index, Rohrer's index, birth weight-to-length ratio and mid-arm-to-head circumference ratio. The size of the thymus was assessed by sonography and expressed as the multiple of transversal width of the cranial thymus part and sagittal area of the major thymus lobe (so-called 'Thymic Index'). The Thymic Index showed a positive correlation with the majority of indicators of the newborn's nutritional status, but all of these correlations are low (Spearman correlation coefficients 0.228-0.409). The correlation of the size of thymus with the birth weight or birth weight-to-length ratio was stronger than the correlation with the Quételet's index or mid-arm circumference. The size of the thymus reflects the newborn's nutritional status assumed by anthropometry and can represent one of the "barometers of nutrition". Normal nutrition in the prenatal period plays a relatively critical role in the development of the immune system.

Association among size of thymus, anthropometric dimensions and number of lymphocytes in peripheral blood in newborns from Slovakia.

AIMS: Thymus is the central lymphatic organ in humans with important endocrine function that is involved in maturation of immunocompetent T-lymphocytes. In our study we investigated the relationship among thymus size and the anthropometric dimensions as well as between thymus size and the number of lymphocytes in peripheral blood in full-term newborns. METHODS: The examined group consisted of 212 full-term newborns from the region of Southern Slovakia. We examined birth weight, birth body length, head circumference and chest circumference. Thymus size was estimated by ultrasonography and it was expressed as Thymic Index. The number of lymphocytes in peripheral blood was determined from the number of total leukocytes and from the leukogram. RESULTS: We have found a statistically significant positive correlation among thymus size and the body dimensions of newborns. The highest correlation with thymus size was found for birth weight (r = 0.409; P < 0.001) followed by birth body length (r = 0.368; P < 0.001), head circumference (r = 0.365; P < 0.001) and chest circumference (r = 0.340; P < 0.001). We have proven also a statistically significant positive correlation between the number of lymphocytes in peripheral blood and thymus size (r = 0.208; P = 0.039). CONCLUSION: Our results confirmed the findings of other authors about a close relationship of Thymic Index and basic body parameters in newborns.