ABSTRACT
The straight correlation between the intensity of stroma inflammatory infiltration and the vessel endothelium growth factor (VEGF) was registered. The progression of the pancreatic tissue fibrosis correlated with the decrease of endothelial and fibroblastic activity, increase of perivascular fibrosis and cellular expression of VEGF, as well as the decrease of compensatory capacity of pancreatic cells.
Subject(s)
Capillaries/pathology , Pancreas/blood supply , Pancreatitis, Chronic/pathology , Vascular Endothelial Growth Factor A/biosynthesis , Adult , Aged , Aged, 80 and over , Disease Progression , Female , Humans , Male , Middle Aged , Pancreas/metabolism , Pancreas/pathology , Pancreatitis, Chronic/metabolismABSTRACT
Matrix metalloproteinases-7, -9 (MMP) are crucial factors for prognosis of pancreatic ductal adenocarcinoma (PDA). The expressions of MMP-2, 7, 9 increased in 60 patients with PDA and depended from stage of disease. Metastasis and invasive growth of tumor correlated with increase of MMP production and decrease of MMP inhibitors' expression, stimulated invasive growth of tumor.
Subject(s)
Carcinoma, Pancreatic Ductal/enzymology , Collagenases/biosynthesis , Gene Expression Regulation, Enzymologic , Gene Expression Regulation, Neoplastic , Neoplasm Proteins/biosynthesis , Pancreatic Neoplasms/enzymology , Adult , Aged , Aged, 80 and over , Carcinoma, Pancreatic Ductal/pathology , Female , Humans , Male , Middle Aged , Neoplasm Invasiveness , Neoplasm Metastasis , Pancreatic Neoplasms/pathologyABSTRACT
The authors describe a case of hepatoid adenocarcinoma of the lung with multiple metastases to the small bowel. An immunohistochemical study has been conducted.
Subject(s)
Adenocarcinoma/secondary , Jejunal Neoplasms/secondary , Lung Neoplasms/pathology , Adenocarcinoma/surgery , Aged , Humans , Immunohistochemistry , Jejunal Neoplasms/surgery , Lung Neoplasms/surgery , Male , Recurrence , alpha-Fetoproteins/analysisABSTRACT
The authors describe a case of goblet-cell carcinoid of the appendix subject to additional immunohistological study. Goblet-cell carcinoid is a rare colonic tumor comprises the morphological signs of adenocarcinoma and carcinoid.
Subject(s)
Adenocarcinoma/pathology , Carcinoid Tumor/pathology , Colonic Neoplasms/pathology , Adenocarcinoma/immunology , Aged , Carcinoid Tumor/immunology , Colonic Neoplasms/immunology , Humans , MaleABSTRACT
Ixodes, persulcatus, I. ricinus, D. reticulatus, D. marginatus, H. concinna were recorded in different regional environmental regions. The northern districts of the region are endemic for tick-borne encephalitis (TBE) and Ixodes tick-borne borreliosis (ITBB). The infection of ticks with TBE virus is 0.25%, that with Borrelia is 10.3% of the total number of the examinees. In 1997 TBE and TTBB morbidity rates were 1.91 and 2.0 per 100,000, respectively. Data on the phenology of prevailing Anopheles messeae are given. Human malaria contamination may take 99-102 days (the first ten days of June to the second ten days of September). The large size of malaria mosquitoes and the presence of imported cases of malaria make it possible to deteriorate the malaria epidemiological situation. The larvicidal activity of a preparation derived from shepherd's-purse (Capsella bursa pastoris) [correction of caseweed (Bursae pastoris)] was tested. 80-85% deaths of larvae of second-third ages occurred 48 hours after treatment with the preparation, 1 kg/ha.