[Difficulties of diagnostic and therapeutic policy in association of purulent intracranial processes with inflammatory ENT diseases]. / Trudnosti diagnostiki i vrachebnoi taktiki pri sochetanii gnoinykh vnutricherepnykh protsessov s vospalitel'nymi LOR-zabolevaniiami.

The paper analyses treatment given to 125 patients with purulent intracranial processes combining with inflammatory diseases of the paranasal sinuses, ear and other diseases. Otorhinogenic genesis was diagnosed in 45.6% cases. Often, affections of the paranasal sinuses and ear mask the true reason of the intracranial pathology, making problems for diagnosis and choice of therapeutic policy. Differential-diagnostic features of the diseases which may complicate with purulent intracranial processes as well as urgent therapeutic measures are described.

[Cause-effect relationship in combination of purulent intracranial processes with ENT diseases]. / O prichinno-sledstvennykh sviaziakh pri sochetanii gnoinykh vnutricherepnykh protsessov s zabolevaniiami LOR-organov.

36 case histories were analyzed. The patients had purulent intracranial processes combined with inflammation of the paranasal sinuses and ear. Cause-effect relationships in development of the above diseases are considered. It was found that paranasal and auricular inflammation combined with purulent intracranial processes do not cause always the latter. The ENT diseases may develop not only in parallel with purulent intracranial pathology, but also as its complication. It is shown that post-mortem hyperdiagnosis exists of ethmoidal and sphenoid inflammation as a cause of purulent intracranial processes.

[On the therapeutic methods of facial bone injuries]. / O taktike lecheniia travm litsevogo skeleta.

The authors present clinicomorphological characteristics of 2293 patients with benign neoplasms of the vocal cords. Nodules predominated in females, contact granulomas in males. Histological and histochemical evidence indicates that polyp-like new growths of the vocal cords known as fibromas, angiofibromas and nodules are not tumors. They are rather edematous, edematous-fibrous and angiomatous polyps arising as a reaction of vocal cords mucosa to phonatory trauma or chemical irritants.

[Regencur hydrogel sinus absorption in the treatment of chronic purulent sinusitis]. / Sinosorbtsiia gidrogeliami regenkura pri lechenii khronicheskogo gnoinogo gaimorita.

Local application of hydrogels based on the sorbent regencur with dioxidine was tried for efficacy against chronic purulent maxillary sinusitis in 30 patients versus matched controls. Changes in the subjective and objective manifestations of the disease were registered on the sensor-analog and visual-analog scales. The findings indicate higher efficacy of regencur hydrogels with dioxidine.

[Effectiveness of local magnetic field of the acoustic frequency in the treatment of patients with acute inflammatory diseases of the larynx]. / Effektivnost' lokal'nogo magnitnogo polia zvukovoi chastoty pri lechenii bol'nykh s ostrymi vospalitel'nymi zabolevaniiami gortani.

The authors have tried alternative magnetic field of sound frequency in patients with acute inflammatory diseases of the larynx. The above modality proved highly efficient in view of its bacteriological, immunomodulating and detoxication actions at cellular level, which make the method promising in physiotherapy of acute inflammation.

[The clinico-immunological assessment of the efficacy of magnetic-laser therapy in patients with chronic maxillary sinusitis]. / Kliniko-immunologicheskaia otsenka éffektivnosti magnitolazernoi terapii u bol'nykh khronicheskim gaimoritom.

Magneto-laser therapy (80 Hz, 0.01 mW/cm2, 12 min) consisting of 10 sessions was performed in patients with maxillary sinusitis (MS). Therapeutic action on the sinus mucosa was conducted through the sinus anterior wall. The magneto-optic attachment coupled with semiconductor laser in the Uzor apparatus was tightly pressed to the facial skin in the sinus projection area. Positive clinical responses associated with stimulation of neutrophil phagocytic activity and with a rise in the portion of rosette-forming neutrophils and Ig A were achieved in 90% of the patients with catarrhal MS and in 83% of those with purulent MS. A 1.5-2-year follow-up registered the effect persistence in 80% and 69% of them, respectively. Compared to standard methods (microwave therapy), magneto-laser treatment was superior both in short-term and long-term effects obtained in purulent MS. The method can be applied in mono- and polytherapy.

[Clinical and biochemical aspects in the treatment of acute maxillary sinusitis with antioxidants]. / Kliniko-biokhimicheskie obosnovaniia primeneniia antioksidantov v lechenii ostrykh verkhnecheliustnykh sinusitov.

A trial has been made of traditional versus antioxidant treatment of acute maxillary sinusitides. The patients were injected a mixture consisting of 4 ml emulsion of 10% dibunol liniment and 2 ml of 5% ascorbic acid made by dilution of 10 g dibunol in 30 ml sterile 0.5% novocaine solution. The mixture was introduced into the sinuses 2 times a day, in one of the study groups it was combined with 500,000 U of ampicillin in cases of purulent sinusitis. In catarrhal form the mixture was injected once a day without the antibiotic. Control groups received 4 ml dioxidine in a single dose after the sinus lavage in catarrhal sinusitis and 500,000 U ampicillin plus hydrocortisone emulsion (1 ml in 4 ml solution) 2 times a day in case of purulent sinusitis. All the patients received aevit (one capsule daily). The mean number of manipulations for the study groups were 4.4 +/- 0.4 in catarrhal sinuses and 6.3 +/- 0.5 in purulent sinusitis; in control groups, respectively, 5.9 +/- 0.5 and 10.7 +/- 0.7. Mean duration of treatment reached 5.3 +/- 0.4, 6.2 +/- 0.3 and 7.1 +/- 0.1 in the study groups and 8.5 +/- 0.2, 10.2 +/- 0.4 days in the control groups. Positive response to the treatment with antioxidants was confirmed by positive changes in blood levels of LPO products, activity of lysosomal hydrolases and antioxidant defense enzymes. The results obtained justify the inclusion of antioxidants in the schemes of acute sinusitis treatment.

[Effect of dibunol on the course of experimental sinusitis]. / Vliianie dibunola na techenie éksperimental'nogo sinusita.

Experimental sinusitis in rabbits was induced by a chemical burn of the mucous membrane. Local application of dibunol decreased the intensity of the purulent inflammation in the sinuses and that of perifocal serous inflammation. Serous inflammation of the contralateral sinus was practically absent. The amount of the lipid peroxidation products in the circulating blood in rabbits receiving dibunol was close to the control and statistically lower than in animals not treated with dibunol. The activity of local acid phosphatase, glucuronidase, marker lysosomal hydrolases and that of myeloperoxidase was lower in animals treated with dibunol, particularly at the pick of inflammation, this was probably due to the dibunol stabilizing effect on the cell membranes.