Mesotelioma multiquístico benigno: primer caso reportado en Bolivia / Benign multicystic mesothelioma: first reported case in Bolivia

Hasta 2 013 sólo 130 casos de quistes mesentéricos habían sido descritos en el mundo, por lo que constituye un hallazgo bastante raro de diagnóstico difícil, por la sintomatología poco específica, sin hallazgos imagenológicos patognomónicos, que en todos los casos requiere un abordaje quirúrgico y estudio histopatológico. Presentamos el primer caso descrito en la literatura boliviana, de mesotelioma multiquístico peritoneal benigno en una paciente de sexo femenino, con cuadro de 3 meses de evolución, caracterizado por dolor y aumento de volumen en hipogastrio, asociado a dificultad para miccionar, con evidencia imagenológica de masa pélvica de origen vesical u ovárico, realizándose laparotomía exploradora y estudio histopatológico para determinar diagnóstico, presentó evolución favorable y fue dada de alta con sonda foley. Actualmente realiza controles regulares por ginecología oncológica y oncología clínica.

Until 2 013 only 130 cases of mesenteric cysts have been described in the world, which is a rare find with difficulties to diagnose by uns-pecific symptoms, without pathognomonic imaging findings, which in all cases require surgical approach and histopathological study. We report the first case described in Bolivian literature of bening peritoneal multicystic mesothelioma benign in a female patient with Table 3 months of evolution, characterized by pain and increased volume in lower abdomen, difficulty in urination associated with radiographical evidence bladder pelvic mass or ovarian origin, performing laparotomy and histopathological study to determine diagnosis the patients presented a favorable evolution and she was discharged with foley catheter. Currently she has regular controls by gynecologic oncology and clinical oncology.

Influence of cranberry juice on glucan-mediated processes involved in Streptococcus mutans biofilm development.

Cranberry juice (CJ) has biological properties that may provide health benefits. In this study, we investigated the influence of CJ (pH 5.5) on several activities in vitro associated with the development of Streptococcus mutans UA159 biofilms. The ability of CJ to influence the adherence of S. mutans to either saliva- (sHA) or glucan-coated hydroxyapatite (gsHA), and to inhibit the glucan production by purified glucosyltransferases adsorbed to sHA was determined. For the adherence assays, we used both uncoated and saliva-coated bacterial cells. Furthermore, we examined whether CJ interferes with the viability, development, polysaccharide composition and acidogenicity of S. mutans biofilms. A solution containing equivalent amounts of glucose, fructose and organic acids at pH 5.5 was used as negative control. The adherence of S. mutans (uncoated and saliva-coated) to either sHA or gsHA treated with 25% CJ (v/v) was remarkably reduced (40-85% inhibition compared to control: p < 0.05), indicating that CJ effectively blocked the bacterial adherence to binding sites in salivary pellicle and in glucans. In contrast, when the bacterial cells alone were treated with CJ they adhered to the similar untreated surfaces. Cranberry juice (25%, v/v) also inhibited the activities of surface-adsorbed GTF B and C (70-80% inhibition compared to control, p < 0.05). The effect of CJ on the viability of microorganisms in biofilms was not significant. Biofilm formation and accumulation were significantly reduced by topical applications of 25% CJ (v/v) twice daily with 1-min exposures (p < 0.05). The biomass and insoluble glucan content of the biofilms in addition to its acidogenicity were significantly reduced by cranberry treatments (p < 0.05). Our data show that cranberry juice inhibited glucan-mediated biofilm development and acid production, and holds promise as a natural product to prevent biofilm-related oral diseases.

Diagnostico ecográfico de acretismo placentario / Ultrasound diagnosis of placental accreta

El acretismo placentario consiste en la adherencia anormal de la placenta a una decidua defectuosa o al miometrio, conduciendo a una demora en el alumbramiento o a la retención placentaria, asociada además a una hemorragia postparto que puede requerir o no histerectomía. Hoy, gracias al mejor entendimiento y conocimiento de los factores de riesgo y al mejoramiento de las pruebas diagnosticas, la mayoría de los casos de placenta acreta puede y deben ser diagnosticados durante el embarazo. La valoración de la morfología y localización placentaria es parte de la evaluación ultrasonográfica obstétrica de rutina, lo cual permite el diagnóstico antenatal de la localización anómala de la placenta y su posible invasión a las demás capas de la estructura uterina. El diagnóstico temprano, hace posible la preparación adecuada y correcta para el momento del parto y sus complicaciones.

The accreta of placenta is the anormal adherence of placenta to a deficient deciduas or to myometrum, leading to a delay in placenta expulsion or to placenta retention. It is associated to a post partum blooding which sometimes can corrected only with hysterectomy. Currently because the better understanding of risk factors and improved diagnostic tests, most of patients with placenta accreta could be diagnosticed throughout pregnancy. Evaluation of morphology and location of placenta form part of routine ecography obstetric assessment, which allow prenatal diagnostics of abnormal position of placenta and the possible invasion to other uterine layers. The early diagnostics make possible patients have an adequate and correct preparation for the partum and prevent its complications.