Au@SiO2 SERS nanotags based lateral flow immunoassay for simultaneous detection of aflatoxin B1 and ochratoxin A.

Agricultural products are frequently contaminated by mycotoxins. Multiplex, ultrasensitive, and rapid determination of mycotoxins is still a challenging problem, which is of great significance to food safety and public health. Herein, a surface-enhanced Raman scattering (SERS) based lateral flow immunoassay (LFA) for the simultaneous on-site determination of aflatoxin B1 (AFB1) and ochratoxin A (OTA) on the same test line (T line) was developed, in this study. In practice, two kinds of Raman reporters 4-mercaptobenzoic acid (4-MBA), and 5,5'-dithiobis-(2-nitrobenzoic acid) (DTNB) encoded silica-encapsulated gold nanotags (Au4-MBA@SiO2 and AuDNTB@SiO2) were used as detection markers to identify the two different mycotoxins. Through systematic optimization of the experimental conditions, this biosensor has high sensitivity and multiplexing with the limits of detection (LODs) at 0.24 pg mL-1 for AFB1 and 0.37 pg mL-1 for OTA. These are far below the regulatory limits set by the European Commission, in which the minimum LODs for AFB1 and OTA are 2.0 and 3.0 µg kg-1. In the spiked experiment, the food matrix are corn, rice, and wheat, and the mean recoveries of the two mycotoxins ranged from 91.0% ± 6.3%-104.8% ± 5.6% for AFB1 and 87.0% ± 4.2%-112.0% ± 3.3% for OTA. These results demonstrate that the developed immunoassay has good stability, selectivity, and reliability, which can be used for routine monitoring of mycotoxin contamination.

A 3D Biocompatible Plasmonic Tweezer for Single Cell Manipulation.

Plasmonic tweezers are an emerging research topic because of their low input power and wide operating range from homogeneous particles to complex biological objects. But it is still challenging for plasmonic tweezers to trap or manipulate objects of tens of microns, especially in biological science. This study introduces a new 3D biocompatible plasmonic tweezer for single living cell manipulation in solution. The key design is a tapered tip whose three-layer surface structure consists of nanoprobe, gold nanofilm, and thermosensitive hydrogel, thiolated poly(N-isopropylacrylamide). Incident light excites the surface plasmon polaritons on gold film and generates heat to induce thermally driven phase transition of the thermosensitive hydrogel, which enables reversible binding between functionalized surface and cell membrane and avoids both thermal and mechanical stresses in the meanwhile. The 3D biocompatible plasmonic tweezer realizes selective capture, 3D pathway free transport, and position-controlled release of target cells, and it displays excellent biocompatibility, low energy consumption, and high operational flexibility.

Simulating an Integrated Photonic Image Classifier for Diffractive Neural Networks.

The slowdown of Moore's law and the existence of the "von Neumann bottleneck" has led to electronic-based computing systems under von Neumann's architecture being unable to meet the fast-growing demand for artificial intelligence computing. However, all-optical diffractive neural networks provide a possible solution to this challenge. They can outperform conventional silicon-based electronic neural networks due to the significantly higher speed of the propagation of optical signals (≈108 m.s-1) compared to electrical signals (≈105 m.s-1), their parallelism in nature, and their low power consumption. The integrated diffractive deep neural network (ID2NN) uses an on-chip fully passive photonic approach to achieve the functionality of neural networks (matrix-vector operations) and can be fabricated via the CMOS process, which is technologically more amenable to implementing an artificial intelligence processor. In this paper, we present a detailed design framework for the integrated diffractive deep neural network and corresponding silicon-on-insulator integration implementation through Python-based simulations. The performance of our proposed ID2NN was evaluated by solving image classification problems using the MNIST dataset.

On-Chip Reconfigurable Focusing through Low-Loss Phase Change Materials Based Metasurfaces.

Metasurfaces are useful subwavelength structures that can be engineered to achieve useful functionality. While most metasurfaces are passive devices, Phase Change Materials can be utilized to make active metasurfaces that can have numerous applications. One such application is on-chip beam steering which is of vital utility for numerous applications that can potentially lead to analog computations and non-Von Neumann computational architectures. This paper presents through numerical simulations, a novel metasurface that can realize beam steering through active phase switching of in-planted arrays of phase change material, Sb2S3. For the purpose of numerical demonstration of the principle, beam focusing has been realized, on-chip, through active switching of the Sb2S3 unit cell between the amorphous and crystalline phases. The presented architecture can realize on-chip transformation optics, mathematical operations, and information processing, thus opening the gates for future technologies.

Polarization-insensitive 1D unidirectional compact grating coupler for the C-band using a 500 nm SOI.

Grating couplers are an important optical interconnect and have increasingly found their utility in sensing and LIDARs as well. Optical systems in general have been struggling to increase their bandwidths, making polarization insensitivity highly desirable. The standard 220 nm silicon-on-insulator (SOI) platform used for integrated photonics suffers from physical bottlenecks in the form of large modal differences in effective refractive index, propagation loss, and dispersion. In this paper, we present a grating coupler for polarization-insensitive coupling with polarization-dependent loss of less than 0.2 dB for more than 80% of the C-band on an alternative 500 nm SOI platform. We further show that the same design can be extended to polarization inflexible coupling and can reduce the polarization-dependent loss to less than 0.08 dB for the complete C-band. This platform is devoid of shortcomings, making it better suited for polarization-insensitive photonics, and the coupler is able to achieve these results through a simple and compact 1D design.

Phase change material enabled 2 × 2 silicon nonvolatile optical switch.

Recently, large-scale photonic integrated circuits have seen rapid development. Optical switches are the elementary units used to realize optical routers and processors. However, the high static power and large footprint of silicon electro-optic and thermo-optic switches are becoming an obstacle for further scaling and high-density integration. In this Letter, we demonstrate a 2×2 nonvolatile silicon Mach-Zehnder optical switch enabled by low-loss phase change material Sb2S3. Changing the phase state of Sb2S3 can switch the optical transmission between the bar and cross paths. As no static power is required to maintain the phase state, it can find promising applications in optical switch matrices and reconfigurable optical circuits.

Hybrid dual-gain tunable integrated InP-Si3N4 external cavity laser.

We present a hybrid dual-gain integrated external cavity laser with full C-band wavelength tunability. Two parallel reflective semiconductor optical amplifier gain channels are combined by a Y-branch in the Si3N4 photonic circuit to increase the optical gain. A Vernier ring filter is integrated in the Si3N4 photonic circuit to select a single longitudinal mode and meanwhile reduce the laser linewidth. The side-mode suppression ratio is ∼67 dB with a pump current of 75 mA. The linewidth of the unpackaged laser is 6.6 kHz under on-chip output power of 23.5 mW. The dual-gain operation of the laser gives higher output power and narrower linewidth compared to the single gain operation. It is promising for applications in optical communications and light detection and ranging systems.

Photothermal Effect in Plasmonic Nanotip for LSPR Sensing.

The influence of heat generation on the conventional process of LSPR based sensing has not been explored thus far. Therefore, a need exists to draw attention toward the heat generation issue during LSPR sensing as it may affect the refractive index of the analyte, leading to incorrect sensory conclusions. This manuscript addresses the connection between the photo-thermal effect and LSPR. We numerically analyzed the heat performance of a gold cladded nanotip. The numerical results predict a change in the micro-scale temperature in the microenvironment near the nanotip. These numerical results predict a temperature increase of more than 20 K near the apex of the nanotip, which depends on numerous factors including the input optical power and the diameter of the fiber. We analytically show that this change in the temperature influences a change in the refractive index of the microenvironment in the vicinity of the nanotip. In accordance with our numerical and analytical findings, we experimentally show an LSPR shift induced by a change in the input power of the source. We believe that our work will bring the importance of temperature dependence in nanotip based LSPR sensing to the fore.