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1.
J Craniomaxillofac Surg ; 48(7): 661-665, 2020 Jul.
Article in English | MEDLINE | ID: mdl-32518020

ABSTRACT

OBJECTIVE: The aim of this study was to assess the quality of online information for patients on orthognathic surgery. MATERIALS AND METHODS: A selection of search terms specific for orthognathic surgery was chosen and 150 websites were identified using the Internet search engines Google, Yahoo and Bing. Irrelevant websites were excluded. The remaining websites were assessed with a modified Ensuring Quality Information for Patients (EQIP) tool. EQIP evaluates the quality of medical patient information by measuring the three key aspects of content, structure, and identification data. RESULTS: 48 relevant websites were identified. EQIP values ranged between 2 and 28 (median 13.65). While 37 of the 48 websites described details of the surgical procedures, only 13 mentioned possible risks and complications of the surgery. No differences were found between the websites of private practices, dentists and public hospitals, universities, or others (p = 0.66). Websites found by Google had a significantly lower EQIP score compared with Yahoo and Bing (11.12 vs. 16.60 for Yahoo and 16.23 for Bing; p = 0.012). The better the rank of the website, the higher the EQIP score (r = -0.411, p = 0.004). CONCLUSIONS: The results of this study reflected a large variation of quality of information on orthognathic surgery on the Internet. Therefore, surgeons must be aware that they might be confronted with unrealistic expectations of patients, who may underestimate the potential risks and drawbacks of orthognathic surgery.


Subject(s)
Consumer Health Information , Orthognathic Surgery , Humans , Internet
2.
J Craniomaxillofac Surg ; 48(5): 521-526, 2020 May.
Article in English | MEDLINE | ID: mdl-32303420

ABSTRACT

Oral and maxillofacial surgery is correlated with a high risk of SARS-CoV-2 transmission. Therefore, the aim of the review is to collect and discuss aspects of the management of patients in oral and maxillofacial surgery during the COVID-19 pandemic. In order to save resources and to avoid unnecessary exposure to infected patients, there is the need to schedule interventions depending on their priority. During the peak of the pandemic, no elective surgery should be performed. Even urgent procedures might be postponed if there is a view to recovery of a COVID-19 patient within a few days. Emergency procedures do not allow any delay. Specialties with overlap in therapies should have well defined arrangements among each other concerning the treatment spectra in order to avoid redundancy and loss of resources. Inpatient and outpatient units have to be organized in such a way that the risk of cross-infection among patients is reduced to a minimum. Especially, testing of patients for SARS-CoV-2 is important to detect the infected patients at an early stage. When surgery is performed on COVID-19 patients, adequate personal protective equipment is crucial. There must be negative pressure in the operating room, and aerosol formation must be reduced to a minimum. In order to address the COVID-19 challenge adequately, significant changes in the infrastructure of outpatient units, inpatient units, and operating rooms are needed. In addition, the demands concerning personal protective equipment increase significantly. The major aim is to protect patients as well as the medical staff from unnecessary infection, and to keep the healthcare system running effectively. Therefore, every effort should be taken to make the necessary investments.


Subject(s)
Betacoronavirus , Coronavirus Infections , Infection Control/methods , Infectious Disease Transmission, Patient-to-Professional/prevention & control , Pandemics , Personal Protective Equipment , Pneumonia, Viral , Surgery, Oral , Aerosols , COVID-19 , COVID-19 Testing , Clinical Laboratory Techniques , Coronavirus Infections/diagnosis , Coronavirus Infections/epidemiology , Coronavirus Infections/prevention & control , Coronavirus Infections/transmission , Elective Surgical Procedures , Humans , Pandemics/prevention & control , Pneumonia, Viral/diagnosis , Pneumonia, Viral/epidemiology , Pneumonia, Viral/prevention & control , Pneumonia, Viral/transmission , SARS-CoV-2 , Surgery, Oral/methods
3.
Clin Oral Investig ; 24(5): 1651-1661, 2020 May.
Article in English | MEDLINE | ID: mdl-31414271

ABSTRACT

OBJECTIVES: The preclinical study aimed to establish a standardized preclinical model to investigate osseous graft consolidation in defect configurations of limited regenerative capacity. MATERIAL AND METHODS: Critical size defects (CSD) were prepared and titanium tubes inserted for defect separation from local bone in the forehead area of 18 pigs. Defects were filled with demineralized bovine bone mineral (DBBM) or served as empty controls and were covered with a resorbable collagen membrane (CM) or left untreated. Six randomly selected pigs were sacrificed after 4, 8 and 12 weeks. Specimens were histologically and histomorphometrically analysed focusing on newly formed bone (NFB), demineralized bovine bone mineral (DBBM) and soft tissue (ST) proportions. RESULTS: Four weeks after defect preparation, no statistically significant difference concerning NFB quantity could be detected within the groups. Defects covered with the CM showed lower amounts of DBBM. After 6 and 12 weeks, defects augmented with DBBM in combination with a CM (8 weeks: 43.12 ± 4.31; 12 weeks: 43.05 ± 3.01) showed a statistically significant higher NFB rate compared to empty control defects covered with 8 weeks: 7.66 ± 0.59; 12 weeks or without a CM; 8 weeks: 8.62 ± 2.66; 12 weeks: 18.40 ± 2.40. CM application showed no significant impact on osseous defect regeneration or soft tissue formation. Superior NFB could be detected for basal aspect for several evaluation time points. CONCLUSIONS: The modification of CSD with titanium tubes represents a suitable model to imitate a one-wall defect regeneration situation. CLINICAL RELEVANCE: The established model represents a promising method to evaluate graft consolidation in one-wall defect configuration.


Subject(s)
Bone Regeneration , Bone Substitutes , Minerals/therapeutic use , Skull/injuries , Animals , Cattle , Collagen , Forehead , Swine , Titanium
4.
Mod Pathol ; 32(8): 1068-1081, 2019 07.
Article in English | MEDLINE | ID: mdl-30936424

ABSTRACT

Leukoplakia is a potential precursor of oral as well as laryngeal squamous cell carcinoma. Risk assessment of malignant transformation based on the grade of dysplasia of leukoplakia often does not lead to reliable results. However, oral squamous cell carcinoma, laryngeal squamous cell carcinoma, and leukoplakia express single or multiple members of the melanoma-associated antigens A (MAGE-A) family, while MAGE-A are absent in healthy mucosal tissue. The present study aimed at determining if there is an association between the expression of MAGE-A in leukoplakia and malignant transformation to oral or laryngeal squamous cell carcinoma. Paraffin-embedded tissues of 205 oral and laryngeal leukoplakia, 90 corresponding tumors, and 40 healthy oral mucosal samples were included in the study. The grade of dysplasia of the leukoplakia samples was determined histopathologically. The leukoplakia samples were divided into lesions that transformed to oral and laryngeal squamous cell carcinoma (n = 91) and lesions that did not (n = 114) during a 5 years follow-up. The expression of MAGE-A3/6 and MAGE-A4 was analyzed by real-time RT-PCR. The expression of MAGE-A 1-4, 6, and 12 was determined by immunohistochemistry. A total of 59.3% of the transforming leukoplakia expressed at least one of the examined antigens as opposed to an expression rate of 3.5% of all non-transforming leukoplakia. There was no MAGE-A expression in healthy oral mucosa. The risk of malignant transformation was statistically significantly associated with MAGE-A expression in immunohistochemistry (p < 0.001) and real-time RT-PCR (MAGE-A3/6, p = 0.001; MAGE-A4, p = 0.002) analyses. There was no significant association between MAGE-A expression and the grade of dysplasia ("low-grade", D0/D1; "high-grade", D2/D3) in immunohistochemistry (p = 0.412) and real-time RT-PCR (MAGE-A3/6, p = 0.667; MAGE-A4, p = 0.756). It seems that the analysis of the MAGE-A expression profile may support the identification of leukoplakia at risk for malignant transformation. Therefore, efforts should be made to establish this analysis as a routine procedure in addition to conventional histopathology.


Subject(s)
Antigens, Neoplasm/analysis , Biomarkers, Tumor/analysis , Cell Transformation, Neoplastic/immunology , Laryngeal Neoplasms/immunology , Leukoplakia, Oral/immunology , Neoplasm Proteins/analysis , Squamous Cell Carcinoma of Head and Neck/immunology , Adult , Aged , Antigens, Neoplasm/genetics , Biomarkers, Tumor/genetics , Case-Control Studies , Cell Transformation, Neoplastic/genetics , Cell Transformation, Neoplastic/pathology , Female , Humans , Laryngeal Neoplasms/genetics , Laryngeal Neoplasms/pathology , Leukoplakia, Oral/genetics , Leukoplakia, Oral/pathology , Male , Middle Aged , Neoplasm Grading , Neoplasm Proteins/genetics , Risk Assessment , Risk Factors , Squamous Cell Carcinoma of Head and Neck/genetics , Squamous Cell Carcinoma of Head and Neck/pathology , Time Factors
5.
J Craniomaxillofac Surg ; 47(1): 53-59, 2019 Jan.
Article in English | MEDLINE | ID: mdl-30470467

ABSTRACT

BACKGROUND: Various causes for bone defects of the lower jaw have been described. As a result, patients often suffer from compromised aesthetics and a loss of, or reduction in, important physiological functions, such as swallowing, breathing, and speaking. A change in the shape of the lower jaw can impair the natural occlusion and leads to an atypical or modified position of the temporomandibular joint. Titanium reconstruction plates are the standard approach to jaw reconstruction, and are used for temporary bridging of a jaw defect or fixation of a bone graft. Conventionally these plates are intraoperatively adjusted to the mandible by the surgeon. Computer-aided manufacturing, computer-aided design, and rapid prototyping have gained increasing importance in the field of medicine, as they allow the production of individual models of the lower jaw, with the possibility of preoperatively bending the reconstruction plates. In this retrospective study, the accuracy of pre-bent titanium plates and their effect on the temporomandibular joint situation in comparison with intraoperatively curved plates will be discussed. MATERIALS AND METHODS: Patients who attended our department for lower jaw reconstruction between March 2013 and February 2015 were included in this retrospective study. Within that time 20 patients were treated with pre-bent reconstruction plates (group 1). 20 comparable patients were selected with reconstruction and conventional intraoperative bending (group 2). To evaluate the accuracy of the plates and the condylar position, postoperative cone beam computed tomograms and computed tomograms were used to assess the bone-plate distance at 12 defined points and four angles in axial reconstruction. The results were compared, statistically evaluated, and discussed. RESULTS: Regarding the maximum bone-plate distances and the sum of distances, there was a significant difference between the accuracy of the pre-bent and the conventionally bent reconstruction plates (p = 0.022, p = 0.048). Regarding the condylar position, there was no significant difference between both methods (p = 0.867). CONCLUSION: The results of this study show that a better fitting accuracy can be achieved using pre-bent plates. Preparation of the plates proves to be advantageous and meaningful, especially in complex bone defects and deformations of the lower jaw. Nevertheless, concerning the position of the temporomandibular joint, no significant difference could be ascertained between the shown methods, contradicting several studies.


Subject(s)
Bone Plates , Mandible/surgery , Mandibular Reconstruction/methods , Plastic Surgery Procedures/methods , Temporomandibular Joint/surgery , Adult , Aged , Aged, 80 and over , Bone Transplantation , Computer-Aided Design , Cone-Beam Computed Tomography , Esthetics, Dental , Female , Humans , Male , Mandible/diagnostic imaging , Mandibular Condyle/diagnostic imaging , Mandibular Condyle/surgery , Middle Aged , Osteotomy/methods , Printing, Three-Dimensional , Prosthesis Fitting , Retrospective Studies , Surgery, Computer-Assisted/methods , Surgical Flaps , Temporomandibular Joint/diagnostic imaging , Titanium , Tomography, X-Ray Computed , Treatment Outcome
6.
Clin Oral Investig ; 23(1): 509, 2019 01.
Article in English | MEDLINE | ID: mdl-30543024

ABSTRACT

The following note was inadvertently omitted from the published paper: This work was performed in (partial) fulfillment of the requirements for the first author's obtaining the degree Dr. med. dent.

7.
Cancer Biomark ; 24(1): 19-30, 2019.
Article in English | MEDLINE | ID: mdl-30594916

ABSTRACT

BACKGROUND: Altered expressions of miR-186, miR-494 and miR-3651 in whole blood of OSCC patients have already been demonstrated. However, nothing is known about their expression in tumor tissues. This study aimed at evaluating differences in miRNA expression in OSCC tissues compared to healthy oral mucosa and at checking if the altered expression is reflected in corresponding blood. METHODS: In 53 OSCC and 40 healthy mucosal tissues the expression of miR-186, -494 and -3651 was determined by RT-qPCR and expression levels were compared between the groups. The altered expression in tissues was compared with that determined for corresponding blood. MiR-3651 target genes were identified using TargetScan software. RESULTS: Differential expression of miR-186 and miR-494 could not be observed in tumor tissues compared to normal mucosa (pmiR-186= 0.13; pmiR-494= 0.35). Contrary to the detected upregulation of the miR-3651 in the blood of OSCC patients, a significant downregulation was observed in OSCC tissues. A significant correlation between underexpression and diagnosis was ascertained (p= 0.0001). 1710 possible target genes of miR-3651 were identified. CONCLUSIONS: Decreased expression of miR-3651 in OSCC tissues may be a diagnostic biomarker. The opposite change in expression level in the blood might indicate different functions of this miRNA in circulation and tissue.


Subject(s)
Biomarkers, Tumor , Carcinoma, Squamous Cell/diagnosis , Carcinoma, Squamous Cell/genetics , MicroRNAs/genetics , Mouth Neoplasms/diagnosis , Mouth Neoplasms/genetics , Adolescent , Adult , Aged , Aged, 80 and over , Case-Control Studies , Female , Gene Expression Regulation, Neoplastic , Humans , Male , MicroRNAs/blood , Middle Aged , Mouth Neoplasms/blood , Neoplasm Grading , Neoplasm Staging , Organ Specificity , RNA Interference , ROC Curve , Reproducibility of Results , Young Adult
8.
J Craniomaxillofac Surg ; 46(4): 705-708, 2018 Apr.
Article in English | MEDLINE | ID: mdl-29526412

ABSTRACT

The current surgical techniques used in cleft repair are well established, but different centers use different approaches. To determine the best treatment for patients, a multi-center comparative study is required. In this study, we surveyed all craniofacial departments registered with the German Society of Maxillofacial Surgery to determine which cleft repair techniques are currently in use. Our findings revealed much variation in cleft repair between different centers. Although most centers did use a two-stage approach, the operative techniques and timing of lip and palate closure were different in every center. This shows that a retrospective comparative analysis of patient outcome between the participating centers is not possible and illustrates the need for prospective comparative studies to establish the optimal technique for reconstructive cleft surgery.


Subject(s)
Cleft Lip/surgery , Cleft Palate/surgery , Surgery, Oral/statistics & numerical data , Age Factors , Germany , Humans , Infant , Practice Patterns, Physicians' , Surgery, Oral/methods , Surveys and Questionnaires
9.
Clin Oral Investig ; 22(4): 1625-1630, 2018 May.
Article in English | MEDLINE | ID: mdl-29572686

ABSTRACT

OBJECTIVES: This study aimed to identify anatomical areas where resections of oral squamous cell carcinomas (OSCC) are significantly associated with close or positive margins. MATERIALS AND METHODS: This retrospective study included 330 patients with a primary OSCC from 2010 to 2015. Patient and tumour data were categorised into three groups by R-status (R0 [clear], ≥ 5 mm, 185 patients [56.06%]; R1 [positive], < 1 mm, 24 patients [7.27%]; and R0 [close], 1-5 mm, 121 patients [36.67%]). RESULTS: Areas where resections were significantly associated with close or positive margins were the hard palate (p < 0.001), buccal mucosa (p = 0.03), floor of the mouth (p = 0.004), lower alveolar ridge (p = 0.01), retromolar triangle (p = 0.005), and dorsal tongue (p = 0.02). CONCLUSIONS: Anatomical areas were identified in the oral cavity where it is challenging to resect OSCCs with an adequate safety margin. CLINICAL RELEVANCE: These results may enable surgeons to achieve a postulated safe distance during tumour resection, leading to a survival benefit for patients.


Subject(s)
Carcinoma, Squamous Cell/surgery , Margins of Excision , Mouth Neoplasms/surgery , Anatomic Landmarks , Carcinoma, Squamous Cell/pathology , Female , Humans , Male , Middle Aged , Mouth Neoplasms/pathology , Neoplasm Grading , Neoplasm Staging , Retrospective Studies
10.
Oncol Rep ; 37(6): 3467-3474, 2017 Jun.
Article in English | MEDLINE | ID: mdl-28498442

ABSTRACT

Currently, there is a lack of blood markers for the detection of recurrent oral squamous cell carcinoma (OSCC). The present study aimed to investigate whether the aberrant expression of single microRNAs (miRNAs) in whole blood of patients could serve as a biomarker for persistent or recurrent OSCC. Whole blood of 2 groups of formerly treated OSCC patients was investigated by RT-qPCR for their circulating miRNA profiles. The R-OC group included patients with recurrence of OSCC (n=21) and the NR-OC group included patients without recurrence (n=21). Fold-changes and significance of the differences in miRNA expression levels between the groups were determined. A cut-off point (COP) for the discrimination between the R-OC and NR-OC groups was calculated and the significance between over/under expression of the miRNAs and the recurrence of malignancy was determined. Significant differences in the miRNA expression in whole blood of the R-OC and NR-OC groups were found. The levels of miR-3651 and miR-494 were significantly increased and the level of miR-186 was significantly decreased in whole blood of the R-OC patients (pmiR-3651=0.001, pmiR-494=0.003 and pmiR-186=0.001). By the determination of the COP, increased or decreased expression of the markers was significantly correlated to the recurrence of the disease. Altered expression of miR-494, miR-3651 and miR-186 appears to be associated with the recurrence of OSCC. The present study may form the basis for establishing a blood test as a minimally invasive method for the detection of the recurrence of OSCC.


Subject(s)
Carcinoma, Squamous Cell/blood , MicroRNAs/genetics , Mouth Neoplasms/blood , Proteins/genetics , Adult , Aged , Aged, 80 and over , Carcinoma, Squamous Cell/genetics , Carcinoma, Squamous Cell/pathology , Female , Gene Expression Regulation, Neoplastic , Humans , Male , MicroRNAs/blood , Microfilament Proteins , Middle Aged , Mouth Neoplasms/genetics , Mouth Neoplasms/pathology , Neoplasm Recurrence, Local/blood , Neoplasm Recurrence, Local/genetics , Neoplasm Recurrence, Local/pathology , Prognosis , RNA-Binding Proteins
11.
J Craniomaxillofac Surg ; 45(5): 614-619, 2017 May.
Article in English | MEDLINE | ID: mdl-28336319

ABSTRACT

Acceptance of new technology is influenced by a number of situational and social factors. So far, only limited data are available on the influence of the teaching staff's gender on the acceptance of virtual dental implant planning by students. This study aimed at assessing the influence of the teaching staff's gender on the acceptance of a virtual implant planning course by male and female undergraduate dental students and their general attitude toward implantology. Two groups of third-year dental students (group 1, 9 males, 22 females; group 2, 12 males, 20 females) attended a virtual dental implant planning course. For the first group the teaching staff was all-male, while the teaching staff was all-female for the second group. After completion of the course the students filled in a technology acceptance questionnaire. An all-female teaching staff led to a degree of technology acceptance that did not differ significantly for male and female students. When the teaching staff was all-male, significant differences for technology acceptance occurred between male and female students. However, male as well as female students attributed the practice of implantology to both genders of dentists, equally, without statistically significant difference independent of the gender of the teaching staff. The more evenly distributed degree of technology acceptance of students of both genders being taught by a female staff is a favorable effect which may be explained by the more egalitarian style of women. Therefore, while feminization in dentistry proceeds, adequate measures should be taken to increase the number of female teachers.


Subject(s)
Computer-Aided Design , Dental Implantation/education , Faculty, Dental , Students, Dental/psychology , Adult , Attitude of Health Personnel , Curriculum , Female , Humans , Male , Sex Factors , Surgery, Computer-Assisted/education , Surgery, Computer-Assisted/methods , Surveys and Questionnaires , User-Computer Interface , Young Adult
12.
Anticancer Res ; 36(11): 6093-6096, 2016 11.
Article in English | MEDLINE | ID: mdl-27793937

ABSTRACT

AIM: To study if the angiotensin receptor blocker olmesartan reduces levels of plasminogen activator inhibitor 1 (PAI1), a risk factor for oral cancer, in a mouse model and therefore whether it could be used in the treatment of this malignancy. MATERIALS AND METHODS: Twelve transgenic PAI1 mice aged 16-20 weeks were divided in two groups each containing six animals. One group was given olmesartan every day for 30 days in drinking water in an amount corresponding to their weight, 0.005 mg/g, while the second group did not receive any medication (control group). Blood samples were obtained from animals of both groups, before and after one month of olmesartan administration and plasma PAI1 levels were measured using enzyme-linked immunosorbent assay. RESULTS: In the olmesartan-treated group, a significant decrease of PAI1 level was found after 1 month of treatment (11.9±8.6 vs. 21.7±7.2 ng/ml, respectively; p=0.028). However, no statistically significant difference was observed in PAI1 levels between the olmesartan-treated and control groups after one month, (p=0.177). CONCLUSION: Olmesartan did not significantly affect PAI1 levels in this mouse model.


Subject(s)
Angiotensin II Type 1 Receptor Blockers/pharmacology , Imidazoles/pharmacology , Mouth Neoplasms/prevention & control , Plasminogen Activator Inhibitor 1/blood , Tetrazoles/pharmacology , Animals , Female , Humans , Male , Mice , Mice, Transgenic , Risk Factors
13.
J Craniomaxillofac Surg ; 44(7): 827-34, 2016 Jul.
Article in English | MEDLINE | ID: mdl-27209350

ABSTRACT

OBJECTIVES: The study aims to establish a peri-implant dehiscence-type bone defect in a diabetic animal model of human bone repair and to quantify the influence of diabetes on peri-implant bone regeneration. MATERIAL AND METHODS: Experimental diabetes was induced in three domestic pigs by streptozotocin. Three animals served as healthy controls. After 12 months four standardized peri-implant dehiscence bone defects were surgically created in the ramus mandibulae. The animals were sacrificed after 90 days. Samples were histologically analyzed to quantify new bone height (NBH), bone-to-implant-contact (BIC), area of newly formed bone (NFB), bone-density (BD), and bone mineralization (BM) in the prepared defect (-D) and in a local control region (-L). RESULTS: After 90 days, diabetic animals revealed a significantly lower BIC (p = 0.037) and BD (p = 0.041) in the defect area (-D). NBH and BM-D differences within the groups were not significant (p > 0.05). Significant more NFB was measured in the healthy control group (p = 0.046). In the region of local bone BIC-L was significant less in the diabetic group (p = 0.028). In the local control region BD-L and BM-L was lower in the diabetic group compared to the healthy control animals (p > 0.05). CONCLUSION: Histological evidence indicates impaired peri-implant defect regeneration in a diabetic animal model.


Subject(s)
Bone Regeneration/physiology , Diabetes Mellitus, Experimental/physiopathology , Mandible/surgery , Mandibular Prosthesis Implantation , Animals , Bone Density/physiology , Calcification, Physiologic/physiology , Diabetes Mellitus, Experimental/pathology , Osteogenesis/physiology , Swine , Wound Healing/physiology
14.
J Craniomaxillofac Surg ; 44(5): 579-83, 2016 May.
Article in English | MEDLINE | ID: mdl-27017103

ABSTRACT

Orthognathic surgery has always been a classical focus of maxillofacial surgery. Since more than 100 years, various surgical techniques for mandibular repositioning have been developed and clinically tested. Since the establishment of plate and screw osteosynthesis, orthognathic surgery became more stable and safe. Nowadays, different surgical methods for mobilising the mandible are existing. This international multicenter analysis (n = 51 hospitals) is providing first evidence based data for the current use of different surgical methods. The dominating techniques were Obwegeser/dal Pont (61%) followed by Hunsuck/Epker (37%) and Perthes/Schlössmann (29%). The main osteosynthesis materials were plates (82%), bicortical screws (23.5%), or a combination of both (5.9%). 47% of all centers reported to use several surgical methods at the same time, depending on the anatomical problem and the surgeon's preference. This shows that different surgical methods seem to work as comparable, safe, and reliable procedures in everydays clinical practise. On this basis, further prospective studies could evaluate possible advantages for our patients.


Subject(s)
Mandible/surgery , Orthognathic Surgical Procedures/statistics & numerical data , Bone Plates/statistics & numerical data , Bone Screws/statistics & numerical data , Humans
15.
Int J Prosthodont ; 29(1): 53-8, 2016.
Article in English | MEDLINE | ID: mdl-26757329

ABSTRACT

The present clinical case history report describes an interdisciplinary treatment protocol that combines maxillary tumor resection with immediate reconstruction to achieve functional rehabilitation. A fibula flap that received four dental implants and a split-thickness graft epithelial layer was prefabricated for a 31-year-old man. The flap was designed so that it could be adapted to fit in different extents of tumor resection. Resection and immediate reconstruction were successfully performed 6 weeks after flap prefabrication, with the final bar-retained dental prosthesis delivered 4 weeks later.


Subject(s)
Bone Transplantation/methods , Free Tissue Flaps/transplantation , Maxillary Neoplasms/surgery , Odontogenic Tumors/surgery , Plastic Surgery Procedures/methods , Adult , Computer-Aided Design , Dental Implantation, Endosseous/instrumentation , Dental Prosthesis, Implant-Supported , Denture Design , Denture, Partial, Temporary , Fibula/transplantation , Humans , Male , Maxilla/surgery , Maxillary Sinus Neoplasms/surgery , Neoplasm Invasiveness , Printing, Three-Dimensional , Skin Transplantation/methods , Surgery, Computer-Assisted/methods
16.
Cleft Palate Craniofac J ; 53(6): 736-740, 2016 11.
Article in English | MEDLINE | ID: mdl-26575963

ABSTRACT

For full-arch reconstruction of an atrophied cleft maxilla with missing premaxilla, a prefabricated microvascular free bony flap is a relevant option. A fibula flap was prefabricated in a cleft patient who received six dental implants and an epithelial layer. Six weeks later, maxillary reconstruction was performed. The inpatient period could be confined to 2 weeks. A fixed provisional prosthesis was delivered after an additional 2 weeks. A prefabricated flap allows for the reduction of the interval without a dental prosthesis to only a few weeks, even when a complex full-arch reconstruction of the maxilla is required.


Subject(s)
Cleft Lip/surgery , Cleft Palate/surgery , Fibula/transplantation , Mastication , Plastic Surgery Procedures , Dental Implants , Humans , Male , Maxilla , Middle Aged , Palate , Surgical Flaps/transplantation
17.
J Craniomaxillofac Surg ; 43(10): 2129-35, 2015 Dec.
Article in English | MEDLINE | ID: mdl-26498514

ABSTRACT

Diagnostic imaging of head and neck cancer has made enormous progress during recent years. Next to morphological imaging modalities (computed tomography [CT] and magnetic resonance imaging [MRI]), there are also hybrid imaging systems that combine functional and morphological information (positron emission tomography [PET]/CT and PET/MRI). The aim of this study was to compare the diagnostic accuracy of PET/MRI in the diagnosis of head and neck cancer with other imaging modalities (MRI, CT, PET/CT). Ten patients (nine male and one female) with histologically proven oral squamous cell carcinoma participated in an 18 F-FDG-PET/CT scan and an additional 18 F-FDG PET/MRI scan prior to surgery. The morphological and functional results were compared with the histological results. Inclusion criteria were histologically proven oral squamous cell carcinoma and no prior surgical intervention, medical therapy, or local external radiation. There was no significant correlation between tumor differentiation and maximum standard uptake values. Functional imaging showed a slightly better correlation with the measurement of the maximal tumor diameter, whereas pure morphological imaging showed a better correlation with the measurement of infiltration depth. Only with PET/MRI could correct lymph node staging be reached; the other imaging tools showed false-negative or false-positive results. In conclusion, we showed in our limited patient cohort that PET/MRI is superior to the morphological imaging modalities, especially for lymph node staging.


Subject(s)
Carcinoma, Squamous Cell/diagnostic imaging , Magnetic Resonance Imaging/methods , Mouth Neoplasms/diagnostic imaging , Positron Emission Tomography Computed Tomography/methods , Female , Humans , Male , Pilot Projects , Radiopharmaceuticals
18.
Sensors (Basel) ; 15(10): 25416-32, 2015 Oct 01.
Article in English | MEDLINE | ID: mdl-26437416

ABSTRACT

The protection of sensitive structures (e.g., nerves) from iatrogenic damage is of major importance when performing laser surgical procedures. Especially in the head and neck area both function and esthetics can be affected to a great extent. Despite its many benefits, the surgical utilization of a laser is therefore still limited to superficial tissue ablation. A remote feedback system which guides the laser in a tissue-specific way would provide a remedy. In this context, it has been shown that nerval structures can be specifically recognized by their optical diffuse reflectance spectra both before and after laser ablation. However, for a translation of these findings to the actual laser ablation process, a nerve protection within the laser pulse is of utmost significance. Thus, it was the aim of the study to evaluate, if the process of Er:YAG laser surgery--which comes with spray water cooling, angulation of the probe (60°) and optical process emissions--interferes with optical tissue differentiation. For the first time, no stable conditions but the ongoing process of laser tissue ablation was examined. Therefore, six different tissue types (nerve, skin, muscle, fat, cortical and cancellous bone) were acquired from 15 pig heads. Measurements were performed during Er:YAG laser ablation. Diffuse reflectance spectra (4500, wavelength range: 350-650 nm) where acquired. Principal component analysis (PCA) and quadratic discriminant analysis (QDA) were calculated for classification purposes. The clinical highly relevant differentiation between nerve and bone was performed correctly with an AUC of 95.3% (cortial bone) respectively 92.4% (cancellous bone). The identification of nerve tissue against the biological very similar fat tissue yielded good results with an AUC value of 83.4% (sensitivity: 72.3%, specificity: of 82.3%). This clearly demonstrates that nerve identification by diffuse reflectance spectroscopy works reliably in the ongoing process of laser ablation in spite of the laser beam, spray water cooling and the tissue alterations entailed by tissue laser ablation. This is an essential step towards a clinical utilization.


Subject(s)
Connective Tissue/innervation , Facial Nerve/pathology , Facial Nerve/surgery , Laser Therapy , Animals , Connective Tissue/pathology , Connective Tissue/surgery , Facial Bones/innervation , Facial Bones/pathology , Facial Muscles/innervation , Facial Muscles/pathology , Facial Muscles/surgery , Laser Therapy/adverse effects , Laser Therapy/instrumentation , Laser Therapy/methods , Lasers, Solid-State , Optical Phenomena , Oral Surgical Procedures/adverse effects , Oral Surgical Procedures/methods , Sensitivity and Specificity , Skin/innervation , Skin/pathology , Swine
19.
J Craniomaxillofac Surg ; 43(8): 1335-9, 2015 Oct.
Article in English | MEDLINE | ID: mdl-26189144

ABSTRACT

OBJECTIVES: Three-dimensional radiological imaging data play an increasingly role in planning, simulation, and navigation in oral and maxillofacial surgery. The aim of this study was to establish a new, highly precise, in vitro measurement technology for the evaluation of the geometric accuracy down to the micrometric range of digital imaging data. MATERIAL AND METHODS: A macerated human mandible was scanned optically with an industrial, non-contact, white light scanner, and a three-dimensional (3D) model was obtained, which served as a master model. The mandible was then scanned 10 times by cone beam computed tomography (CBCT), and the generated 3D surface bone model was virtually compared with the master model. To evaluate the accuracy of the CBCT scans, the standard deviation and the intraclass coefficient were determined. RESULTS: A total of 19 measurement points in 10 CBCT scans were investigated, and showed an average value of 0.2676 mm with a standard deviation of 0.0593 mm. The standard error of the mean was 0.0043 mm. The intraclass correlation coefficient (ICC) within the 10 CBCT scans was 0.9416. CONCLUSIONS: This highly precise measuring technology was demonstrated to be appropriate for the evaluation of the accuracy of digital imaging data, down to the micrometric scale. This method is able to exclude human measurement errors, as the software calculates the superimposition and deviation. Thus inaccuracies caused by measurement errors can be avoided. This method provides a highly precise determination of deviations of different CBCT parameters and 3D models for surgical, navigational, and diagnostic purposes. Thus, surgical procedures and the post-operative outcomes can be precisely simulated to benefit the patient.


Subject(s)
Cone-Beam Computed Tomography/statistics & numerical data , Image Processing, Computer-Assisted/statistics & numerical data , Imaging, Three-Dimensional/statistics & numerical data , Anatomic Landmarks/anatomy & histology , Anatomic Landmarks/diagnostic imaging , Cadaver , Computer-Aided Design/statistics & numerical data , Cone-Beam Computed Tomography/standards , Fiducial Markers , Humans , Image Processing, Computer-Assisted/standards , Imaging, Three-Dimensional/standards , Mandible/anatomy & histology , Mandible/diagnostic imaging , Models, Anatomic , Optical Imaging/statistics & numerical data , Surgery, Computer-Assisted/standards , User-Computer Interface
20.
J Craniomaxillofac Surg ; 43(6): 913-7, 2015 Jul.
Article in English | MEDLINE | ID: mdl-25964007

ABSTRACT

The aim of the present study was to perform a bibliometric analysis of the gender distribution of first and senior authorships in important oral and maxillofacial journals over the 30-year period from 1980 to 2010. Articles published in three representative oral and maxillofacial surgery journals were selected. The years 1980, 1990, 2000, and 2010 were chosen as representative points in time for article selection. Original research, case reports, technical notes, and reviews were included in the analysis. Case reports and technical notes were pooled in one group. For each article, the gender of the first author as well as that of the senior author was determined, based on the inspection of their first name. The type of article was determined and the country of origin of the article was documented. A total 1412 articles were subjected to the data analysis. A significant increase in female authorship in oral and maxillofacial surgery could be identified over the chosen 30-year period. However, the number of publications by male authors was still significantly higher at all points of time, exceeding those of female authors by at least 3.8 fold in 2010. As there is a trend towards feminization of medicine and dentistry, the results of the present study may serve as the basis for further analysis of the current situation, and the identification of necessary actions to accelerate the closure of the gender gap in publishing in oral and maxillofacial surgery.


Subject(s)
Authorship , Bibliometrics , Periodicals as Topic/statistics & numerical data , Surgery, Oral/statistics & numerical data , Africa , Americas , Asia , Dental Records/statistics & numerical data , Dental Research/statistics & numerical data , Europe , Female , Humans , Male , Publishing/statistics & numerical data , Review Literature as Topic , Sex Factors , Sexism/statistics & numerical data , Technology, Dental/statistics & numerical data
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