Subject(s)
Diabetes Mellitus, Type 2/genetics , Glucokinase/genetics , Adolescent , Adult , Belgium , Child , Child, Preschool , Humans , Luxembourg , MutationSubject(s)
Insulinoma/complications , Muscular Diseases/etiology , Pancreatic Neoplasms/complications , Cell Membrane/pathology , Child , Creatine Kinase/blood , Electromyography , Humans , Insulinoma/surgery , Male , Muscle Fatigue , Muscle Fibers, Skeletal/pathology , Muscular Diseases/pathology , Muscular Diseases/surgery , Pancreatic Neoplasms/surgeryABSTRACT
Broncholithiasis is a rare but distinct and potentially dangerous pulmonary problem that still needs to be considered in the differential diagnosis of some patients with bronchial obstruction. Broncholiths originate from calcified material in peribronchial lymph nodes eroding into the tracheobronchial tree. The clinical and chest X-ray signs are usually non-specific, but the diagnosis can nowadays be made based on clinical suspicion, CT-scan and fibre-optic bronchoscopy findings, so that a malignant cause of airway obstruction can be ruled out. The removal of broncholiths during fibre-optic bronchoscopy is seldom possible and rather dangerous. They can be removed safely by rigid bronchoscopy with the aid of Nd-YAG laser photocoagulation. Thoracotomy is indicated in complicated cases with fistula formation or severe bleeding.