[Progress in the study of artemisinin and its derivatives against head and neck cancer].

The head and neck cancer is one of the most common malignant tumors in the world. There are more than 600 000 new cases in the world every year. Cisplatin is often used in the treatment of head and neck cancer at present. However, because of its side effects and drug resistance, cisplatin often failed in the treatment of head and neck cancer. Artemisinin and its derivatives as first-line antimalarial drugs have the advantages of high efficiency, low toxicity and so on. Further study found that artemisinin and its derivatives had cytotoxic effects against head and neck cancer through inducing cell cycle arrest, inducing tumor cell apoptosis and inhibiting cell invasion and migration, oxidative damage, blocking the cell signal transduction and inhibiting angiogenesis. Studying the anti-tumor effects of artemisinin and its derivatives allows for development of safer and more effective antitumor drugs and pain-reduction caused by diseases and traditional treatment, then improve the survival rate and life quality of patients with head and neck cancer. This article reviews the progress in the study of artemisinin and its derivatives in the treatment of head and neck cancer.

[Effect of artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell].

Objective:To observe the effect of Artesunate on the transplantation tumor of parotid gland in the nude mice with adenoid cystic carcinoma drug resistance cell and to explore its clinical application prospect as an anticancer drug.Method:Twenty male BALB/C mice were chose to set up parotid gland transplantation tumor model, then used the method of random Numbers table 20 nude mice were randomly divided into normal saline control group, positive control group DDP 2 mg/kg group, the ART of 200 mg/kg group, ART 100 mg/kg+DDP 1 mg/kg group, a total of 4 groups. Abdominal cavity injection was performed twice a day, and we measured weight of each nude mice and transplantation tumor major axis and minor axis. Treatments were conducted for 4 weeks, then the mice were sacrificed, and tumor weight was measured to calculate the inhibitory rates. The tumors were examined by HE staining to observe each tumor tissue pathological changes and by immunohistochemical method to detect Survivin expression in transplanted tumor tissue. Result:Four weeks after treatments, the inhibitory rate of DDP 2 mg/kg group was 59.86%, but this group of nude mice lost weight obviously； the ART 200 mg/kg group was 43.54%，this group of nude mice had a good mental state, and weight had gaining continuously；the ART 100 mg/kg+DDP 1 mg/kg group was 41.16%, this group of nude mice had reducing weight slightly.HE staining showed:The tumor nuclei were hyperchromatic and shrinkage, nuclear chromatin condensed and cracked into flake in the ART 200 mg/kg group, DDP 2 mg/kg group and the ART 100 mg/kg+DDP 1 mg/kg group. Conclusion:Artesunate can inhibit adenoid cystic carcinoma resistant cells NACC/DDP proliferation in nude mice in vivo and promote its apoptosis, and the side effects of Artesunate on nude mice were lower than Cisplatin.

[Comparison of two approach for facial nerve surgery on facial nerve injury in the parotid benign tumor].

Objective:To compare the function of facial nerves in patients with parotid benign tumors underwent surgery with retrograde method to expose nerve trunk or the marginal mandibular branch.Method:Fifty-five hospital patients from March 2013 to september 2015 were involved in this study and divided into group A(facial nerve trunk exposure, 27 cases), B group(facial nerve mandible branch exposure, 28 cases). Facial nerve injury in two groups was evaluated by observation of abnormal facial performance and electrophysiological techniques. Result:After a follow up of 1 year, the postoperative incidence of facial nerve injury in group A and group B were 7.41% and 25%, respectively, which was evaluated by observation of abnormal facial performance. Moreover,the rates were 14.81%, 30.29%, respectively, which was evaluated by electrophysiological techniques. The rate of postoperative facial nerve injury in group B of patients with was significantly higher than that of group A(P<0.05). Conclusion:Operation with facial nerve trunk exposure can obviously reduce the occurrence of symptoms of facial paralysis in diameter <5 cm of the parotid benign tumor surgery, is suitable for clinical application.

[The expression and clinical significance of survivin in salivary gland adenoid cystic carcinoma: a Meta analysis].

Objective:This Meta-analysis was performed to explore the association between survivin expression and clinical pathological features of salivary gland adenoid cystic carcinoma (SACC). Method:Literature was searched in some databases such as PubMed, Embase, Cochrane Library, web of science, OVID, Springerlink, CNKI, CBM, Wanfang and CQVIP. The pooled odds ratios (ORs) and 95% confidence intervals (95% CIs) were estimated to determine the correlation between survivin expression and SACC using a fixed or random effects model according to heterogeneity. Result:A total of ten studies with 367 SACC patients and 124 normal control subjects were included in this Meta-analysis. The results showed that survivin was overexpressed in SACC tissues (OR=38.26, 95% CI: 17.37-84.29, P<0.01). It also revealed significant correlations between survivin expression and pathological types (OR=0.3, 95% CI: 0.17-0.55, P<0.01), advanced tumor clinical stages (OR=0.23, 95% CI: 0.13-0.42, P<0.01) and lymph node metastasis (OR=3.7, 95% CI: 1.82-7.56, P<0.01). Conclusion:The current study demonstrated that survivin expression may be associated with the clinical pathological features of SACC. However, due to the influence of the quantity and quality of the included literature, additional high quality of studies with larger sample sizes are needed to confirm our findings.