Search | VHL Regional Portal

Disseminated Scedosporium/Pseudallescheria infection after double-lung transplantation in patients with cystic fibrosis.

Morio, Florent; Horeau-Langlard, Delphine; Gay-Andrieu, Françoise; Talarmin, Jean-Philippe; Haloun, Alain; Treilhaud, Michelle; Despins, Philippe; Jossic, Frédérique; Nourry, Laurence; Danner-Boucher, Isabelle; Pattier, Sabine; Bouchara, Jean-Philippe; Le Pape, Patrice; Miegeville, Michel.

J Clin Microbiol ; 48(5): 1978-82, 2010 May.

Article in English | MEDLINE | ID: mdl-20220160

ABSTRACT

We report a case of disseminated Scedosporium/Pseudallescheria infection due to Pseudallescheria boydii sensu stricto after lung transplantation in a patient with cystic fibrosis. Dissemination occurred under voriconazole. Despite surgery and combination therapy with voriconazole, caspofungin, and terbinafine, the patient died 8 months after transplantation. Previously reported cases are reviewed.

Subject(s)

Cystic Fibrosis/therapy , Lung Diseases, Fungal/diagnosis , Lung Transplantation/adverse effects , Pseudallescheria/isolation & purification , Scedosporium/isolation & purification , Adult , Antifungal Agents/therapeutic use , Brain/diagnostic imaging , Caspofungin , Chemoprevention/methods , DNA, Fungal/chemistry , DNA, Fungal/genetics , Echinocandins/therapeutic use , Fatal Outcome , Female , Humans , Lipopeptides , Lung Diseases, Fungal/drug therapy , Lung Diseases, Fungal/microbiology , Lung Diseases, Fungal/surgery , Magnetic Resonance Imaging , Microbial Sensitivity Tests , Microscopy , Molecular Sequence Data , Naphthalenes/therapeutic use , Pseudallescheria/classification , Pseudallescheria/cytology , Pseudallescheria/genetics , Pyrimidines/therapeutic use , RNA, Fungal/genetics , RNA, Ribosomal, 28S/genetics , Radiography , Scedosporium/classification , Scedosporium/cytology , Scedosporium/genetics , Sequence Analysis, DNA , Terbinafine , Triazoles/therapeutic use , Voriconazole

ABSTRACT

Subject(s)

SEND TO:

SELECTION OF CITATIONS

SEARCH DETAIL