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1.
Correction to "Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure".
Lanier, Marion; Pickens, Jason; Bigi, Simone V; Bradshaw-Pierce, Erica L; Chambers, Alison; Cheruvallath, Zacharia S; Cole, Derek; Dougan, Douglas R; Ermolieff, Jacques; Gibson, Tony; Halkowycz, Petro; Hirokawa, Aki; Ivetac, Anthony; McBride, Christopher; Miura, Joanne; Nunez, Evan; Sabat, Mark; Tyhonas, John; Wang, Haixia; Wang, Xiaolun; Swann, Steve.
ACS Med Chem Lett ; 8(12): 1341, 2017 12 14.
Article in English | MEDLINE | ID: mdl-29259759

ABSTRACT

[This corrects the article DOI: 10.1021/acsmedchemlett.6b00481.].

2.
Structure-Based Design of ASK1 Inhibitors as Potential Agents for Heart Failure.
Lanier, Marion; Pickens, Jason; Bigi, Simone V; Bradshaw-Pierce, Erica L; Chambers, Alison; Cheruvallath, Zacharia S; Cole, Derek; Dougan, Douglas R; Ermolieff, Jacques; Gibson, Tony; Halkowycz, Petro; Hirokawa, Aki; Ivetac, Anthony; Miura, Joanne; Nunez, Evan; Sabat, Mark; Tyhonas, John; Wang, Haixia; Wang, Xiaolun; Swann, Steve.
ACS Med Chem Lett ; 8(3): 316-320, 2017 Mar 09.
Article in English | MEDLINE | ID: mdl-28337323

ABSTRACT

Apoptosis signal-regulating kinase 1 (ASK1/MAP3K) is a mitogen-activated protein kinase family member shown to contribute to acute ischemia/reperfusion injury. Using structure-based drug design, deconstruction, and reoptimization of a known ASK1 inhibitor, a lead compound was identified. This compound displayed robust MAP3K pathway inhibition and reduction of infarct size in an isolated perfused heart model of cardiac injury.

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