1.
J Med Chem
; 18(2): 199-203, 1975 Feb.
Article
in English
| MEDLINE
| ID: mdl-1120988
ABSTRACT
The preparation of a series of vulpinic acids, substituted in either or both of the aromatic rings, is described. The compounds were found to be active in the adjuvant arthritis test in rats. High activity combined with an acceptable therapeutic ratio was confined to analogs with electron-withdrawing substituents in the meta positions of the rings.
Subject(s)
Anti-Inflammatory Agents/chemical synthesis , Pyrans/chemical synthesis , Pyrones/chemical synthesis , Animals , Anti-Inflammatory Agents/adverse effects , Anti-Inflammatory Agents/therapeutic use , Arthritis, Rheumatoid/drug therapy , Arthritis, Rheumatoid/immunology , Benzylidene Compounds/adverse effects , Benzylidene Compounds/chemical synthesis , Benzylidene Compounds/therapeutic use , Dose-Response Relationship, Drug , Freund's Adjuvant , Hyperventilation/chemically induced , Pyrones/adverse effects , Pyrones/therapeutic use , Rats , Structure-Activity Relationship
2.
J Chem Soc Perkin 1
; 12: 1501-5, 1968.
Article
in English
| MEDLINE
| ID: mdl-5690071
Subject(s)
Immunosuppressive Agents , Chemical Phenomena , Chemistry , Spectrum Analysis , Thiophenes
3.
Nature
; 210(5036): 638-9, 1966 May 07.
Article
in English
| MEDLINE
| ID: mdl-5964708