What Measures are Effective in Trauma Screening for Young Males in Custody? A COSMIN Systematic Review.

Despite the available evidence identifying the high prevalence rates of potentially traumatic experiences in forensic populations, there is still a lack of evidence supporting the use of suitable assessment tools, especially for young males in custody. For services to identify, support, and offer trauma interventions to this cohort, practitioners require reliable and valid assessment tools. This systematic review (Open Science Framework registration: https://osf.io/r6hbk) identifies those tools able to provide valid, reliable, and comparable data for this cohort. Five electronic databases and gray literature were searched to identify relevant measures. Inclusion criteria: studies of tools to assess for trauma with males aged between 12 and 25 years-old in a custodial setting, any year of publication, and available in English. Exclusion criteria: studies that did not measure psychological trauma or include a standalone trauma scale, or report primary data. A three-step quality assessment method was used to evaluate the methodological quality and psychometric properties of the measures. Fourteen studies were selected for review (which included 12 measures). The studies sampled a total of approximately 1,768 male participants and an age range of 12 to 25 years. The studies reported on various types of psychometric evidence and due to the lack of homogeneity, a narrative synthesis was used to discuss, interpret, and evaluate each measure. The overall quality of the psychometric properties of the measures in this review showed that the currently available instruments for the assessment of trauma with young males in custody is limited but promising.

Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.

Eukaryotic translation initiation factor 4E (eIF4E) is an RNA-binding protein that binds to the m7GpppX-cap at the 5' terminus of coding mRNAs to initiate cap-dependent translation. While all cells require cap-dependent translation, cancer cells become addicted to enhanced translational capacity, driving the production of oncogenic proteins involved in proliferation, evasion of apoptosis, metastasis, and angiogenesis, among other cancerous phenotypes. eIF4E is the rate-limiting translation factor, and its activation has been shown to drive cancer initiation, progression, metastasis, and drug resistance. These findings have established eIF4E as a translational oncogene and promising, albeit challenging, anti-cancer therapeutic target. Although significant effort has been put forth toward inhibiting eIF4E, the design of cell-permeable, cap-competitive inhibitors remains a challenge. Herein, we describe our work toward solving this long-standing challenge. By employing an acyclic nucleoside phosphonate prodrug strategy, we report the synthesis of cell-permeable inhibitors of eIF4E binding to capped mRNA to inhibit cap-dependent translation.

Design of Cell-Permeable Inhibitors of Eukaryotic Translation Initiation Factor 4E (eIF4E) for Inhibiting Aberrant Cap-Dependent Translation in Cancer.

Eukaryotic translation initiation factor 4E (eIF4E) is an RNA-binding protein that binds to the m 7 GpppX-cap at the 5' terminus of coding mRNAs to initiate cap-dependent translation. While all cells require cap-dependent translation, cancer cells become addicted to enhanced translational capacity, driving the production of oncogenic proteins involved in proliferation, evasion of apoptosis, metastasis, and angiogenesis among other cancerous phenotypes. eIF4E is the rate-limiting translation factor and its activation has been shown to drive cancer initiation, progression, metastasis, and drug resistance. These findings have established eIF4E as a translational oncogene and promising, albeit challenging, anti-cancer therapeutic target. Although significant effort has been put forth towards inhibiting eIF4E, the design of cell-permeable, cap-competitive inhibitors remains a challenge. Herein, we describe our work towards solving this long-standing challenge. By employing an acyclic nucleoside phosphonate prodrug strategy, we report the synthesis of cell-permeable inhibitors of eIF4E binding to capped mRNA to inhibit cap-dependent translation.

The effects of Parachlorella kessleri cultivation on brewery wastewater.

Bioindustrial wastewaters, often characterised by high carbon and nitrogen contents, have shown promise as a valuable resource for the cultivation of beneficial microorganisms. The purpose of this study was to assess if Parachlorella kessleri could utilise brewery wastewater (Br WW) for growth and production of metabolites. P. kessleri was cultivated on different concentrations of Br WW over 14 days. Higher concentrations of Br WW led to an approximate two-fold increase in dry cell weight yielding a maximum of 12.3 g DCW/L. High glucose and nitrogen utilisation was associated with high algal biomass yields, with a 97% reduction in glucose achieved in 50% (v/v) Br WW cultures after 14 days. Assessing the benefits to P. kessleri, increases in oleic and α-linoleic acids were seen in 50 and 10% (v/v) Br WW cultures. Concentration of Br WW did not have an impact on the overall antioxidant activities of microalgal cultures, however, it did affect phenolic levels (2.4-fold increase) in 50% (v/v) Br WW cultures. This research demonstrated that P. kessleri did utilise the carbon and nitrogen content in the Br WW for growth and metabolite production, thereby reducing the nutrient load of the Br WW.

Gender differences in work sample assessments: Not all tests are created equal / Diferencias de género en la evaluación de muestras de trabajo: no todas las pruebas se crean por igual

We examined gender differences in five different types of clerical work sample exercises. Our results indicated that, overall, gender differences were minimal. However, there was substantial variability in gender differences across work sample exercises such that the magnitude and direction of gender differences depended on the constructs that each assessed. Gender differences favored females on tests that involved typing skills and verbal comprehension, while gender differences favored males on tests that involved spatial abilities. We found mixed support for the notion that males would outperform females on work sample assessments of technical skills (AU)

Analizamos las diferencias de género en cinco tipos distintos de ejercicios de muestras de trabajo administrativo. Los resultados indican que, en general, las diferencias de género eran mínimas. No obstante, había gran variabilidad en las diferencias de género en los ejercicios de muestras de trabajo en función de los constructos evaluados por cada uno de ellos. Las diferencias de género favorecían a las mujeres en las pruebas que implicaban destrezas mecanográficas y comprensión verbal, mientras que las diferencias de género favorecían a los hombres en pruebas que implicaban aptitudes espaciales. No hubo un apoyo claro con respecto a la noción de que los hombres superan a las mujeres en la evaluación de muestras de trabajo de capacidades técnicas (AU)

RETRACTED: Right to left ventricular volume ratio: A novel marker of disease severity in chronic thromboembolic pulmonary hypertension.

[This retracts the article DOI: 10.1016/j.ijchv.2013.10.001.].