Subject(s)
Bacteriophage Typing , Salmonella Infections/epidemiology , Adolescent , Adult , Aged , Animals , Child , Child, Preschool , Germany, West , Humans , Infant , Middle Aged , Salmonella Food Poisoning/epidemiology , Salmonella typhimuriumABSTRACT
308 digitalized out-patients with artificial cardiac pacemakers were explored for signs of glycoside toxicity with simultaneous determination of digoxin plasma levels 12 hours after the last dose. The incidence of different side effects commonly attributed to overdigitalization did not allow prediction of toxic plasma levels. 55% of all glycoside levels were within the therapeutic range, 34% were below 0.7 ng/ml and only 11% above 2.0 ng/ml. With the most commonly prescribed maintenance doses of the glycosides used (digoxin 0.5 mg, beta-acetyldigoxin 0.4 mg, beta-methyldigoxin 0.2 mg, lanatosid C 1.0 mg) therapeutic plasma levels were reached regularly in 60-65% of the patients. A significant correlation existed between plasma glycoside concentrations and renal function as well as age, but glycoside concentrations could not be correlated with the age of the patients. There were no indications for interactions of the different glycosides prescribed with diuretics or oral antidiabetics.
Subject(s)
Cardiac Glycosides/blood , Pacemaker, Artificial , Adult , Age Factors , Aged , Body Weight , Cardiac Glycosides/pharmacology , Digoxin/analogs & derivatives , Digoxin/blood , Digoxin/poisoning , Diuretics/pharmacology , Drug Interactions , Female , Glomerular Filtration Rate , Humans , Hypoglycemic Agents/pharmacology , Lanatosides/blood , Lanatosides/poisoning , Male , Middle AgedABSTRACT
To successfully combat cancer, research needs to be based on prospective investigations and central collation of data. An initial report is presented concerning one such investigation that has been in progress since September, 1976: "central register and combined study of testicular tumors--Bonn." The aims are to collate epidemiologic data, achieve a standardization of the stages of the cycle of the seminiferous epithelium and of classification, on the model of the WHO, as well as to attain maximum efficiency of diagnosis and therapy. Fourteen participating clinics in the German Federal Republic, Austria, and Switzerland, and 70 submissions of data up to the 1st of March, 1977, amply justify the efforts so far expended and encourage us to solicit the cooperation of previous nonparticipants.