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J Pediatr Hematol Oncol ; 44(2): e612-e615, 2022 03 01.
Article in English | MEDLINE | ID: mdl-34310473

ABSTRACT

Neuroblastoma-associated renal cell carcinoma (RCC) is a very rare subtype of renal neoplasia and only a handful of cases have been reported. Here we present a 15-year-old boy with metastatic RCC with a previous history of advanced stage neuroblastoma and germline mutation in the TP53 tumor suppressor gene. The probability of the RCC and indeed, the neuroblastoma itself being related to a cancer predisposition syndrome rather than a therapy induced second malignancy, is discussed.


Subject(s)
Carcinoma, Renal Cell , Kidney Neoplasms , Neoplasms, Second Primary , Neuroblastoma , Adolescent , Carcinoma, Renal Cell/complications , Carcinoma, Renal Cell/genetics , Carcinoma, Renal Cell/pathology , Female , Germ-Line Mutation , Humans , Kidney Neoplasms/pathology , Male , Neoplasms, Second Primary/pathology , Neuroblastoma/complications , Neuroblastoma/genetics , Neuroblastoma/pathology
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