[Gene protective effect of the short-chain derivative of Vitamin E under the action of alkylating compounds]. / Genoprotektorna dlia korotkolantsiugovogo pokhinogo vitaminu E za umov dii alkiliuchikh spoluk.

The gene protective effect of the short chain derivative of vitamin E was investigated in rats intoxicated with embichin and cyclophosphamide. Prophylactic administration of tocopherol derivative for 14 days promotes reduction of the genome and chromosome disturbances in marrow cells caused by this compounds. Correcting influence of tocopherol derivative depends on chemical structure and biologic peculiarities of the alkylating compound.

[Correcting influence of vitamin E short chain derivatives on lipid peroxidation, liver cell membrane, and chromatin structure when rats are exposed to embichin]. / Korihiuchyi vplyv korotkolantsiuhovoho pokhidnoho vitaminu E na stan protsesiv POL ta strukturuu membran i khromatynu klityn pechinky shchuriv za diï embikhinu.

Embikhin causes activation of LPO processes in endoplasmic reticulum and in nuclear chromatine fractions of rat liver cells. The latter is accompanied by the impairment of repressive and active nuclear chromatine fractions structure. Derivate of vitamin E in these conditions renders correcting action on parameters of lipid peroxidation in the investigated subcellular structures, testifying its positive influence on the cell heredity apparatus state. The normalizing action of tocopherol derivative on cytochromes P450 and b5 levels is shown.