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1.
J Therm Biol ; 121: 103852, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38615495

ABSTRACT

Heat stress is a major factor that negatively affects animal welfare and production systems. Livestock should adapt to tropical and subtropical areas and to meet this, composite breeds have been developed. This work aimed to evaluate gene expression profiles in the skin of Brangus cattle under heat stress using a case-control design, and to correlate this with skin histological characteristics. Two groups of bulls were set using rectal temperature as a criterion to define stress conditions: stressed (N = 5) and non-stressed (N = 5) groups. Skin transcriptomics was performed and correlations between breed composition, phenotypic and skin histological traits were evaluated. Results showed 4309 differentially expressed genes (P < 0.01), 2113 downregulated and 2196 upregulated. Enrichment and ontology analyses revealed 132 GO terms and 67 pathways (P < 0.01), including thermogenesis, glycolysis, gluconeogenesis, mitochondrial activity, antioxidant and immune response, and apoptosis. The identity of the terms and pathways indicated the diversity of mechanisms directed to relieve the animals' suffering, acting from simple passive mechanisms (conduction, convection and radiation) to more complex active ones (behavioural changes, evaporation, vasodilation and wheezing). Furthermore, significant differences between phenotypic and skin histological traits and correlations between pairs of traits suggested a direction towards heat dissipation processes. In this sense, number of vessels was positively correlated with number of sweat glands (P < 0.001) and both were positively correlated with zebuine genetic content (P < 0.05 and P < 0.01, respectively), gland size was positively correlated with epidermal thickness and negatively with hair length (P < 0.05), and epidermal thickness was negatively correlated with gland-epidermis distance (P < 0.0005). These results support the notion that response to heat stress is physiologically complex, producing significant changes in the expression of genes involved in several biological pathways, while the animal's ability to face it depends greatly on their skin features.


Subject(s)
Heat-Shock Response , Skin , Transcriptome , Animals , Cattle/genetics , Cattle/physiology , Heat-Shock Response/genetics , Male , Skin/metabolism , Gene Expression Profiling , Heat Stress Disorders/veterinary , Heat Stress Disorders/genetics , Heat Stress Disorders/metabolism
2.
Cochabamba; UCB; oct. 1998. 73 p. graf.
Monography in Spanish | LILACS, LIBOCS, LIBOE, LIBOSP | ID: lil-231804

ABSTRACT

El presente estudio es una aproximación al problema del abandono de la etapa de seguimiento en el tratamiento de pacientes alcohólicos y farmacodependientes que recibieron asistencia en una de las etapas del mismo, en la modalidad de tratamiento de la Comunidad Terapéutica, en el Instituto Psiquiátrico "San Juan de Dios" de la ciudad de Cochabamba


Subject(s)
Humans , Alcoholism/prevention & control , Alcohols/administration & dosage , Alcoholic Beverages , Alcohol Drinking , Bolivia , Substance-Related Disorders
3.
Cochabamba; OPS; octubre, 1995.
Monography in Spanish | LILACS-Express | LIBOCS, LIBOSP | ID: biblio-1300007
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