ABSTRACT
We study the jamming transition in a model of elastic particles under shear at zero temperature, with a focus on the relaxation time τ_{1}. This relaxation time is from two-step simulations where the first step is the ordinary shearing simulation and the second step is the relaxation of the energy after stopping the shearing. τ_{1} is determined from the final exponential decay of the energy. Such relaxations are done with many different starting configurations generated by a long shearing simulation in which the shear variable γ slowly increases. We study the correlations of both τ_{1}, determined from the decay, and the pressure, p_{1}, from the starting configurations as a function of the difference in γ. We find that the correlations of p_{1} are longer lived than the ones of τ_{1} and find that the reason for this is that the individual τ_{1} is controlled both by p_{1} of the starting configuration and a random contribution which depends on the relaxation path length-the average distance moved by the particles during the relaxation. We further conclude that it is γ_{τ}, determined from the correlations of τ_{1}, which is the relevant one when the aim is to generate data that may be used for determining the critical exponent that characterizes the jamming transition.
ABSTRACT
We do extensive simulations of a simple model of shear-driven jamming in two dimensions to determine and analyze the velocity distribution at different densities Ï around the jamming density Ï_{J} and at different low shear strain rates, γ[over Ì]. We then find that the velocity distribution is made up of two parts which are related to two different physical processes which we call the slow process and the fast process as they are dominated by the slower and the faster particles, respectively. Earlier scaling analyses have shown that the shear viscosity η, which diverges as the jamming density is approached from below, consists of two different terms, and we present strong evidence that these terms are related to the two different processes: the leading divergence is due to the fast process, whereas the correction-to-scaling term is due to the slow process. The analysis of the slow process is possible thanks to the observation that the velocity distribution for different γ[over Ì] and Ï at and around the shear-driven jamming transition has a peak at low velocities and that the distribution has a constant shape up to and slightly above this peak. We then find that it is possible to express the contribution to the shear viscosity due to the slow process in terms of height and position of the peak in the velocity distribution and find that this contribution matches the correction-to-scaling term, determined through a standard critical scaling analysis. A further observation is that the collective particle motion is dominated by the slow process. In contrast to the usual picture in critical phenomena with a direct link between the diverging correlation length and a diverging order parameter, we find that correlations and shear viscosity decouple since they are controlled by different sets of particles and that shear-driven jamming is thus an unusual kind of critical phenomenon.
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Background: What baseline predictors would be involved in mortality in people with primary Sjögren syndrome (SjS) remains uncertain. This study aimed to investigate the baseline characteristics collected at the time of diagnosis of SjS associated with mortality and to identify mortality risk factors for all-cause death and deaths related to systemic SjS activity measured by the ESSDAI score. Methods: In this international, real-world, retrospective, cohort study, we retrospectively collected data from 27 countries on mortality and causes of death from the Big Data Sjögren Registry. Inclusion criteria consisted of fulfilling 2002/2016 SjS classification criteria, and exclusion criteria included chronic HCV/HIV infections and associated systemic autoimmune diseases. A statistical approach based on a directed acyclic graph was used, with all-cause and Sjögren-related mortality as primary endpoints. The key determinants that defined the disease phenotype at diagnosis (glandular, systemic, and immunological) were analysed as independent variables. Findings: Between January 1st, 2014 and December 31, 2023, data from 11,372 patients with primary SjS (93.5% women, 78.4% classified as White, mean age at diagnosis of 51.1 years) included in the Registry were analysed. 876 (7.7%) deaths were recorded after a mean follow-up of 8.6 years (SD 7.12). Univariate analysis of prognostic factors for all-cause death identified eight Sjögren-related variables (ocular and oral tests, salivary biopsy, ESSDAI, ANA, anti-Ro, anti-La, and cryoglobulins). The multivariate CPH model adjusted for these variables and the epidemiological features showed that DAS-ESSDAI (high vs no high: HR = 1.68; 95% CI, 1.27-2.22) and cryoglobulins (positive vs negative: HR = 1.72; 95% CI, 1.22-2.42) were independent predictors of all-cause death. Of the 640 deaths with available information detailing the specific cause of death, 14% were due to systemic SjS. Univariate analysis of prognostic factors for Sjögren-cause death identified five Sjögren-related variables (oral tests, clinESSDAI, DAS-ESSDAI, ANA, and cryoglobulins). The multivariate competing risks CPH model adjusted for these variables and the epidemiological features showed that oral tests (abnormal vs normal results: HR = 1.38; 95% CI, 1.01-1.87), DAS-ESSDAI (high vs no high: HR = 1.55; 95% CI, 1.22-1.96) and cryoglobulins (positive vs negative: HR = 1.52; 95% CI, 1.16-2) were independent predictors of SjS-related death. Interpretation: The key mortality risk factors at the time of SjS diagnosis were positive cryoglobulins and a high systemic activity scored using the ESSDAI, conferring a 2-times increased risk of all-cause and SjS-related death. ESSDAI measurement and cryoglobulin testing should be considered mandatory when an individual is diagnosed with SjS. Funding: Novartis.
ABSTRACT
Birds breeding in urban environments have lower reproductive output compared to rural conspecifics, most likely because of food limitation. However, which characteristics of urban environments may cause this deficiency is not clear. Here, we investigated how tree composition within urban territories of passerine birds is associated with breeding probability and reproductive success. We used 7 years of data of breeding occupancy for blue and great tits (Cyanistes caeruleus; Parus major) and several reproductive traits for great tits, from 400 urban nest boxes located in 5 parks within the city of Malmö, Sweden. We found that tits, overall, were less likely to breed in territories dominated by either non-native trees or beech trees. Great tit chicks reared in territories dominated by non-native trees weighed significantly less, compared to territories with fewer non-native trees. An earlier onset of breeding correlated with increased chick weight in great tits. Increasing number of common oak trees (Quercus robur) was associated with delayed onset of breeding in great tits. Notably, as offspring survival probability generally increased by breeding earlier, in particular in oak-dominated territories, our results suggest that delayed onset of breeding induced by oak trees may be maladaptive and indicate a mismatch to this food source. Our results demonstrate that tree composition may have important consequences on breeding success of urban birds, but some of these effects are not consistent between years, highlighting the need to account for temporal effects to understand determinants of breeding success and inform optimal management in urban green spaces.
Subject(s)
Passeriformes , Songbirds , Animals , Plant Breeding , Food , SwedenABSTRACT
Fine mapping and bioinformatic analysis of the DDX6-CXCR5 genetic risk association in Sjögren's Disease (SjD) and Systemic Lupus Erythematosus (SLE) identified five common SNPs with functional evidence in immune cell types: rs4938573, rs57494551, rs4938572, rs4936443, rs7117261. Functional interrogation of nuclear protein binding affinity, enhancer/promoter regulatory activity, and chromatin-chromatin interactions in immune, salivary gland epithelial, and kidney epithelial cells revealed cell type-specific allelic effects for all five SNPs that expanded regulation beyond effects on DDX6 and CXCR5 expression. Mapping the local chromatin regulatory network revealed several additional genes of interest, including lnc-PHLDB1-1. Collectively, functional characterization implicated the risk alleles of these SNPs as modulators of promoter and/or enhancer activities that regulate cell type-specific expression of DDX6, CXCR5, and lnc-PHLDB1-1, among others. Further, these findings emphasize the importance of exploring the functional significance of SNPs in the context of complex chromatin architecture in disease-relevant cell types and tissues.
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The global movement of bees for agricultural pollination services can affect local pollinator populations via hybridization. When commercial bumblebees are of the same species but of different geographic origin, intraspecific hybridization may result in beneficial integration of new genetic variation, or alternatively may disrupt locally adapted gene complexes. However, neither the existence nor the extent of genomic introgression and evolutionary divergence between wild and commercial bumblebees is fully understood. We obtained whole-genome sequencing data from wild and commercial Bombus terrestris collected from sites in Southern Sweden with and without long-term use of commercially imported B. terrestris. We search for evidence of introgression, dispersal and genome-wide differentiation in a comparative genomic analysis of wild and commercial bumblebees. Commercial B. terrestris were found in natural environments near sites where commercial bumblebees were used, as well as drifting wild B. terrestris in commercial bumblebee colonies. However, we found no evidence for widespread, recent genomic introgression of commercial B. terrestris into local wild conspecific populations. We found that wild B. terrestris had significantly higher nucleotide diversity (Nei's pi, π), while the number of segregating sites (Watterson's theta, θw) was higher in commercial B. terrestris. A highly divergent region on chromosome 11 was identified in commercial B. terrestris and found to be enriched with structural variants. The genes present in this region are involved in flight muscle contraction and structure and pathogen immune response, providing evidence for differing evolutionary processes operating in wild and commercial B. terrestris. We did not find evidence for recent introgression, suggesting that co-occurring commercial B. terrestris have not disrupted evolutionary processes in wild B. terrestris populations.
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We carry out overdamped simulations in a simple model of jamming-a collection of bidisperse soft core frictionless disks in two dimensions-with the aim to explore the finite size dependence of different quantities, both the relaxation time obtained from the relaxation of the energy and the pressure equivalent of the shear viscosity. The motivation for the paper is the observation [Nishikawa et al., J. Stat. Phys. 182, 37 (2021)0022-471510.1007/s10955-021-02710-8] that there are finite size effects in the relaxation time, τ, that give problems in the determination of the critical divergence, and the claim that this is due to a finite size dependence, τâ¼lnN, which makes τ an ill-defined quantity. Beside analyses to determine the relaxation time for the whole system we determine particle relaxation times which allow us to determine both histograms of particle relaxation times and the average particle relaxation times-two quantities that are very useful for the analyses. The starting configurations for the relaxation simulations are of two different kinds-completely random or taken from steady shearing simulations-and we find that the difference between these two cases are bigger than previously noted and that the observed problems in the determination of the critical divergence obtained when starting from random configurations are not present when instead starting the relaxations from shearing configurations. We also argue that the the effect that causes the lnN dependence is not as problematic as asserted. When it comes to the finite size dependence of the pressure equivalent of the shear viscosity we find that our data don't give support for the claimed strong finite size dependence, but also that the finite size dependence is at odds with what one would normally expect for a system with a diverging correlation length, and that this calls for an alternative understanding of the phenomenon of shear-driven jamming.
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OBJECTIVES: Type I IFN (IFN-I) activation is a prominent feature of primary SS (pSS), SLE and SSc. Ultrasensitive single-molecule array (Simoa) technology has facilitated the measurement of subfemtomolar concentrations of IFNs. Here we aimed to measure IFN-α2 in serum from pSS, SLE and SSc using a Simoa immunoassay and correlate these levels to blood IFN-stimulated gene (ISG) expression and disease activity. METHODS: Serum IFN-α2 was measured in patients with pSS (n = 85 and n = 110), SLE (n = 24) and SSc (n = 23) and healthy controls (HCs; n = 68) using an IFN-α Simoa assay on an HD-X analyser. IFN-I pathway activation was additionally determined from serum by an IFN-I reporter assay and paired samples of whole blood ISG expression of IFI44, IFI44L, IFIT1, IFIT3 and MxA by RT-PCR or myxovirus resistance protein 1 (MxA) protein ELISA. RESULTS: Serum IFN-α2 levels were elevated in pSS (median 61.3 fg/ml) compared with HCs (median ≤5 fg/ml, P < 0.001) and SSc (median 11.6 fg/ml, P = 0.043), lower compared with SLE (median 313.5 fg/ml, P = 0.068) and positively correlated with blood ISG expression (r = 0.66-0.94, P < 0.001). Comparable to MxA ELISA [area under the curve (AUC) 0.93], IFN-α2 measurement using Simoa identified pSS with high ISG expression (AUC 0.90) with 80-93% specificity and 71-84% sensitivity. Blinded validation in an independent pSS cohort yielded a comparable accuracy. Multiple regression indicated independent associations of autoantibodies, IgG, HCQ treatment, cutaneous disease and a history of extraglandular manifestations with serum IFN-α2 concentrations in pSS. CONCLUSION: Simoa serum IFN-α2 reflects blood ISG expression in pSS, SLE and SSc. In light of IFN-targeting treatments, Simoa could potentially be applied for patient stratification or retrospective analysis of historical cohorts.
Subject(s)
Interferon Type I , Lupus Erythematosus, Systemic , Sjogren's Syndrome , Antiviral Agents , Autoantibodies , Humans , Retrospective StudiesABSTRACT
OBJECTIVES: To analyse how the main components of the disease phenotype (sicca symptoms, diagnostic tests, immunological markers and systemic disease) can be driven by the age at diagnosis of primary Sjögren's syndrome (pSS). METHODS: By January 2021, the participant centres had included 12,753 patients from 25 countries that fulfilled the 2002/2016 classification criteria for pSS. The age at diagnosis was defined as the time when the attending physician confirmed fulfilment of the criteria. Patients were clustered according to age at diagnosis. 50 clusters with more than 100 observations (from 27 to 76 years) were used to study the influence of the age at diagnosis in the disease expression. RESULTS: There was a consistent increase in the frequency of oral dryness according to the age at diagnosis, with a frequency of <90% in patients diagnosed at the youngest ages and >95% in those diagnosed at the oldest ages. The smooth curves that best fitted a linear model were the frequency of dry mouth (adjusted R2 0.87) and the frequency of abnormal oral tests (adjusted R2 0.72). Therefore, for each 1-year increase in the age at diagnosis, the frequency of dry mouth increased by 0.13%, and the frequency of abnormal oral diagnostic tests by 0.11%. There was a consistent year-by-year decrease in the frequency of all autoantibodies and immunological markers except for cryoglobulins. According to the linear models, for each 1-year increase in the age at diagnosis, the frequency of a positive result decreased by 0.57% (for anti-Ro antibodies), 0.47% (for RF) and 0.42% (for anti-La antibodies). The ESSDAI domains which showed a more consistent decrease were glandular and lymph node involvement (for each 1-year increase in the age at diagnosis, the frequency of activity decreased by 0.18%), and constitutional, cutaneous, and haematological involvements (the frequency decreased by 0.09% for each 1-year increase). In contrast, other domains showed an ascending pattern, especially pulmonary involvement (for each 1-year increase in the age at diagnosis, the frequency of activity increased by 0.22%), and peripheral nerve involvement (the frequency increased by 0.09% for each 1-year increase). CONCLUSIONS: The influence of the age at diagnosis on the key phenotypic features of pSS is strong, and should be considered critical not only for designing a personalised diagnostic approach, but also to be carefully considered when analysing the results of diagnostic tests and immunological parameters, and when internal organ involvement is suspected at diagnosis.
Subject(s)
Sjogren's Syndrome , Big Data , Humans , Sjogren's Syndrome/diagnosis , Sjogren's Syndrome/epidemiologyABSTRACT
Most vertebrates have UV-sensitive vision, but the UV sensitivity of their eyes is limited by the transmittance of the ocular media, and the specific contribution of the different media (cornea, lens) has remained unclear. Here, we describe the transmittance of all ocular media (OMT), as well as that of lenses and corneas of birds. For 66 species belonging to 18 orders, the wavelength at which 50% of light is transmitted through the ocular media to the retina (λT0.5) ranges from 310 to 398â nm. Low λT0.5 corresponds to more UV light transmitted. Corneal λT0.5 varies only between 300 and 345â nm, whereas lens λT0.5 values are more variable (between 315 and 400â nm) and tend to be the limiting factor, determining OMT in the majority of species. OMT λT0.5 is positively correlated with eye size, but λT0.5 of corneas and lenses are not correlated with their thickness when controlled for phylogeny. Corneal and lens transmittances do not differ between birds with UV- and violet-sensitive SWS1 opsin when controlling for eye size and phylogeny. Phylogenetic relatedness is a strong predictor of OMT, and ancestral state reconstructions suggest that from ancestral intermediate OMT, highly UV-transparent ocular media (low λT0.5) evolved at least five times in our sample of birds. Some birds have evolved in the opposite direction towards a more UV-opaque lens, possibly owing to pigmentation, likely to mitigate UV damage or reduce chromatic aberration.
Subject(s)
Birds , Ultraviolet Rays , Animals , Cornea , Phylogeny , RetinaABSTRACT
OBJECTIVES: To characterize the phenotypic presentation at diagnosis of childhood-onset primary SS. METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry using worldwide data-sharing cooperative merging of pre-existing clinical SS databases from the five continents. For this study, we selected those patients in whom the disease was diagnosed below the age of 19 years according to the fulfilment of the 2002/2016 classification criteria. RESULTS: Among the 12 083 patients included in the Sjögren Big Data Registry, 158 (1.3%) patients had a childhood-onset diagnosis (136 girls, mean age of 14.2 years): 126 (80%) reported dry mouth, 111 (70%) dry eyes, 52 (33%) parotid enlargement, 118/122 (97%) positive minor salivary gland biopsy and 60/64 (94%) abnormal salivary US study, 140/155 (90%) positive ANA, 138/156 (89%) anti-Ro/La antibodies and 86/142 (68%) positive RF. The systemic EULAR Sjögren's syndrome disease activity index (ESSDAI) domains containing the highest frequencies of active patients included the glandular (47%), articular (26%) and lymphadenopathy (25%) domains. Patients with childhood-onset primary SS showed the highest mean ESSDAI score and the highest frequencies of systemic disease in 5 (constitutional, lymphadenopathy, glandular, cutaneous and haematological) of the 12 ESSDAI domains, and the lowest frequencies in 4 (articular, pulmonary, peripheral nerve and CNS) in comparison with patients with adult-onset disease. CONCLUSIONS: Childhood-onset primary SS involves around 1% of patients with primary SS, with a clinical phenotype dominated by sicca features, parotid enlargement and systemic disease. Age at diagnosis plays a key role in modulating the phenotypic expression of the disease.
Subject(s)
Severity of Illness Index , Sjogren's Syndrome/pathology , Adolescent , Age of Onset , Female , Humans , Male , Parotid Gland/pathology , Phenotype , Registries , Sjogren's Syndrome/diagnosisABSTRACT
OBJECTIVE: To assess pulmonary function and chronic obstructive pulmonary disease (COPD) development over time in patients with primary Sjögren syndrome (pSS), as well as the association between pulmonary function, radiographic findings, respiratory symptoms, and clinical features of pSS, taking cigarette consumption into account. METHODS: Forty patients with pSS (mean age 66 yrs; range 42-81 yrs; 39 women), previously participating in a cross-sectional study on pulmonary involvement in pSS, were reassessed by pulmonary function tests after a mean follow-up time of 6 years. At follow-up, patients were also assessed by high-resolution computed tomography of the chest, as well as for pSS disease activity, respiratory symptoms, and cigarette consumption. RESULTS: Patients with pSS showed significantly decreased percentages of predicted total lung capacity (TLC), residual volume (RV), RV/TLC ratio, and diffusing capacity of the lungs for carbon monoxide, as well as an increase in predicted forced expiratory volume in 1 second/vital capacity (FEV1/VC) ratio from baseline to follow-up. The proportion of COPD in patients with pSS did not change significantly from baseline to follow-up (38% vs 40%, respectively). Radiographic signs of bronchial involvement and interstitial lung disease were each found in 38% of the patients. CONCLUSION: Both airway and pulmonary parenchymal disease were commonly found in patients with pSS, with a coexistence of both an obstructive and restrictive pulmonary function pattern, where the latter tended to deteriorate over time. COPD was a common finding. Airway and pulmonary involvement may be underdiagnosed in pSS, which is why special attention to clinical assessment of pulmonary involvement in patients with pSS is mandated.
Subject(s)
Pulmonary Disease, Chronic Obstructive , Adult , Aged , Aged, 80 and over , Cross-Sectional Studies , Female , Follow-Up Studies , Humans , Lung/diagnostic imaging , Middle Aged , Pulmonary Disease, Chronic Obstructive/complications , Pulmonary Disease, Chronic Obstructive/diagnostic imaging , Respiratory Function TestsABSTRACT
We study shear-driven jamming of ellipsoidal particles at zero temperature with a focus on the microscopic dynamics. We find that a change from spherical particles to ellipsoids with aspect ratio α=1.02 gives dramatic changes of the microscopic dynamics with much lower translational velocities and a new role for the rotations. Whereas the velocity difference at contacts-and thereby the dissipation-in collections of spheres is dominated by the translational velocities and reduced by the rotations, the same quantity is in collections of ellipsoids instead totally dominated by the rotational velocities. By also examining the effect of different aspect ratios we find that the examined quantities show either a peak or a change in slope at α≈1.2, which thus gives evidence for a crossover between different regions of low and high aspect ratio.
ABSTRACT
We carry out numerical simulations of athermally sheared, bidisperse, frictionless disks in two dimensions. From an appropriately defined velocity correlation function, we determine that there are two diverging length scales, ξ and â, as the jamming transition is approached. We analyze our results using a critical scaling ansatz for the correlation function and argue that the more divergent length â is a consequence of a dangerous irrelevant scaling variable and that it is ξ, which is the correlation length that determines the divergence of the system viscosity as jamming is approached from below in the liquid phase. We find that ξâ¼(Ï_{J}-Ï)^{-ν} diverges with the critical exponent ν=1. We provide evidence that ξ measures the length scale of fluctuations in the rotation of the particle velocity field, while â measures the length scale of fluctuations in the divergence of the velocity field.
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How well can a bird discriminate between two red berries on a green background? The absolute threshold of colour discrimination is set by photoreceptor noise, but animals do not perform at this threshold; their performance can depend on additional factors. In humans and zebra finches, discrimination thresholds for colour stimuli depend on background colour, and thus the adaptive state of the visual system. We have tested how well chickens can discriminate shades of orange or green presented on orange or green backgrounds. Chickens discriminated slightly smaller colour differences between two stimuli presented on a similarly coloured background, compared with a background of very different colour. The slope of the psychometric function was steeper when stimulus and background colours were similar but shallower when they differed markedly, indicating that background colour affects the certainty with which the animals discriminate the colours. The effect we find for chickens is smaller than that shown for zebra finches. We modelled the response to stimuli using Bayesian and maximum likelihood estimation and implemented the psychometric function to estimate the effect size. We found that the result is independent of the psychophysical method used to evaluate the effect of experimental conditions on choice performance.
Subject(s)
Color Perception , Color Vision , Animals , Bayes Theorem , Chickens , ColorABSTRACT
Each year, billions of songbirds cross large ecological barriers during their migration. Understanding how they perform this incredible task is crucial to predict how global change may threaten the safety of such journeys. Earlier studies based on radar suggested that most songbirds cross deserts in intermittent flights at high altitude, stopping in the desert during the day, while recent tracking with light loggers suggested diurnal prolongation of nocturnal flights and common non-stop flights for some species. We analyzed light intensity and temperature data obtained from geolocation loggers deployed on 130 individuals of ten migratory songbird species, and show that a large variety of strategies for crossing deserts exists between, but also sometimes within species. Diurnal stopover in the desert is a common strategy in autumn, while most species prolonged some nocturnal flights into the day. Non-stop flights over the desert occurred more frequently in spring than in autumn, and more frequently in foliage gleaners. Temperature recordings suggest that songbirds crossed deserts with flight bouts performed at various altitudes according to species and season, along a gradient ranging from low above ground in autumn to probably >2000 m above ground level, and possibly at higher altitude in spring. High-altitude flights are therefore not the general rule for crossing deserts in migrant songbirds. We conclude that a diversity of migration strategies exists for desert crossing among songbirds, with variations between but also within species.
Subject(s)
Animal Migration/physiology , Desert Climate , Environment , Flight, Animal/physiology , Songbirds/physiology , Altitude , Animals , Circadian Rhythm/physiology , Geographic Information Systems , Light , Seasons , Songbirds/classification , Species Specificity , Temperature , Time FactorsABSTRACT
We numerically simulate the uniform athermal shearing of bidisperse, frictionless, two-dimensional spherocylinders and three-dimensional prolate ellipsoids. We focus on the orientational ordering of particles as an asphericity parameter αâ0 and particles approach spherical. We find that the nematic order parameter S_{2} is nonmonotonic in the packing fraction Ï and that, as αâ0, S_{2} stays finite at jamming and above. The approach to spherical particles thus appears to be singular. We also find that sheared particles continue to rotate above jamming and that particle contacts preferentially lie along the narrowest width of the particles, even as αâ0.
ABSTRACT
Several studies have shown a negative association between smoking and primary Sjögren's syndrome (pSS), and smoking may interfere with the immune response. The purpose of this study was to investigate if smoking affects disease activity and disease phenotype in pSS. In this cross-sectional study, consecutive pSS patients filled out the EULAR Sjögren's Syndrome Patient Reported Index (ESSPRI) form and a structured questionnaire regarding smoking habits. EULAR Sjögren's Syndrome Disease Activity Index (ESSDAI) scores were calculated and blood samples were analysed for type I interferon signature using RT-PCR. Of 90 patients (93% women, median age 66.5 years), 72% were type I IFN signature positive and 6, 42 and 53% were current, former and never smokers, respectively. No significant differences by smoking status were found regarding ESSDAI total score, activity in the ESSDAI domains or type I IFN signature. Patients with a higher cumulative cigarette consumption (≥ median) had higher scores in ESSPRI total [5.0 (3.0-6.3) vs 8.0 (6.0-8.3); p < 0.01] and ESSPRI sicca and pain domains. Comparing type I IFN signature negative and positive patients, the latter had significantly lower activity in ESSDAI articular domain (7/25 vs 3/64; p < 0.01) and lower scores in ESSPRI total [7.7 (5.2-8.2) vs 6.0 (4.0-7.7); p = 0.04]. Smoking was not associated with disease phenotype although patients with a higher cumulative cigarette consumption had worse symptoms in some disease domains. Current smokers were few making it difficult to draw any firm conclusions about associations to current smoking.
Subject(s)
Cigarette Smoking/adverse effects , Interferon Type I/blood , Sjogren's Syndrome/immunology , Smokers , Aged , Biomarkers/blood , Cigarette Smoking/blood , Cigarette Smoking/immunology , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Phenotype , Risk Factors , Severity of Illness Index , Sjogren's Syndrome/blood , Sjogren's Syndrome/diagnosisABSTRACT
In France, illegal hunting of the endangered ortolan bunting Emberiza hortulana has been defended for the sake of tradition and gastronomy. Hunters argued that ortolan buntings trapped in southwest France originate from large and stable populations across the whole of Europe. Yet, the European Commission referred France to the Court of Justice of the European Union (EU) in December 2016 for infringements to legislation (IP/16/4213). To better assess the impact of hunting in France, we combined Pan-European data from archival light loggers, stable isotopes, and genetics to determine the migration strategy of the species across continents. Ortolan buntings migrating through France come from northern and western populations, which are small, fragmented and declining. Population viability modeling further revealed that harvesting in southwest France is far from sustainable and increases extinction risk. These results provide the sufficient scientific evidence for justifying the ban on ortolan harvesting in France.
Subject(s)
Animal Migration , Conservation of Natural Resources , Endangered Species , Passeriformes/physiology , Animals , Bayes Theorem , Cluster Analysis , Deuterium , European Union , Female , France , Geography , Human Activities , Humans , Isotopes , Male , Middle East , Norway , Population Dynamics , Probability , SeasonsABSTRACT
Collections of bidisperse frictionless particles at zero temperature in three dimensions are simulated with a shear-driven dynamics with the aim to compare with the behavior in two dimensions. Contrary to the prevailing picture, and in contrast to results from isotropic jamming from compression or quench, we find that the critical exponents in three dimensions are different from those in two dimensions and conclude that shear-driven jamming in two and three dimensions belong to different universality classes.