ABSTRACT
Pseudocirrhosis, which is radiologically and clinically similar to liver cirrhosis, may develop following chemotherapy for breast cancer with liver metastasis. There are few reports of eribulin treatment. We report 5 patients with metastatic or recurrent breast cancer who developed pseudocirrhosis during eribulin treatment. All patients had diffuse liver metastasis, and the liver metastases significantly reduced in size during the early phase of eribulin treatment, when they developed pseudocirrhosis. Subsequently, the patients had poor prognoses.
Subject(s)
Breast Neoplasms , Furans , Ketones , Liver Neoplasms , Humans , Ketones/therapeutic use , Ketones/adverse effects , Breast Neoplasms/drug therapy , Breast Neoplasms/pathology , Furans/therapeutic use , Furans/adverse effects , Middle Aged , Female , Aged , Liver Neoplasms/drug therapy , Liver Neoplasms/secondary , Antineoplastic Agents/adverse effects , Antineoplastic Agents/therapeutic use , Recurrence , Polyether PolyketidesABSTRACT
Leuconostoc lactis, often found in fermented dairy products, although considered to have a low pathogenic potential, can cause life-threatening infections in immunocompromised hosts. We herein report a 62-year-old man with a history of alcoholic liver cirrhosis, hepatocellular carcinoma, and diabetes mellitus who developed a very rare case of bacterial meningitis caused by this organism. After we administered antibiotics including ampicillin, he recovered completely within two weeks. This gram-positive coccus (GPC) is sensitive to ampicillin but naturally resistant to vancomycin, while its susceptibility to ceftriaxone has not yet been established. In acute GPC meningitis in immunocompromised hosts, Leuconostoc lactis should therefore be considered as a possible pathogen.