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1.
Bone-modifying drugs slow OA progression.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(6): 319, 2024 Jun.
Article in English | MEDLINE | ID: mdl-38714839

Subject(s)
Bone Density Conservation Agents , Disease Progression , Humans , Bone Density Conservation Agents/therapeutic use , Osteoarthritis/drug therapy
2.
Benralizumab noninferior to mepolizumab for EGPA.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(5): 253, 2024 May.
Article in English | MEDLINE | ID: mdl-38594482

Subject(s)
Antibodies, Monoclonal, Humanized , Antibodies, Monoclonal, Humanized/therapeutic use , Humans , Anti-Asthmatic Agents/therapeutic use , Treatment Outcome
3.
Eosinophils regulate bone remodelling.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(4): 198, 2024 Apr.
Article in English | MEDLINE | ID: mdl-38454053

Subject(s)
Bone Remodeling , Eosinophils , Humans
4.
GWAS data help unravel Dupuytren disease.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(3): 137, 2024 Mar.
Article in English | MEDLINE | ID: mdl-38332241

Subject(s)
Dupuytren Contracture , Humans , Dupuytren Contracture/genetics , Genome-Wide Association Study
5.
B cells guide rituximab use in AAV remission.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(2): 67, 2024 Feb.
Article in English | MEDLINE | ID: mdl-38212541

Subject(s)
Anti-Neutrophil Cytoplasmic Antibody-Associated Vasculitis , Immunosuppressive Agents , Humans , Rituximab/therapeutic use , Glucocorticoids , B-Lymphocytes , Remission Induction , Treatment Outcome , Cyclophosphamide , Antibodies, Antineutrophil Cytoplasmic
6.
Multi-omics reveals distinct MPA subtypes.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(1): 3, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38040801

Subject(s)
Genomics , Multiomics , Humans , Computational Biology
7.
Targeted NOD2 sequencing uncovers JIA misdiagnosis.
Onuora, Sarah.
Nat Rev Rheumatol ; 20(1): 3, 2024 Jan.
Article in English | MEDLINE | ID: mdl-38030937

Subject(s)
Genetic Predisposition to Disease , Nod2 Signaling Adaptor Protein , Humans , Mutation , Nod2 Signaling Adaptor Protein/genetics
8.
L-arginine inhibits arthritis and bone loss by reprogramming osteoclast metabolism.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(12): 760, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37919338

Subject(s)
Arthritis , Bone Resorption , Humans , Arginine/therapeutic use , Arginine/metabolism , Arthritis/drug therapy , Arthritis/metabolism , Bone Resorption/drug therapy , Bone Resorption/metabolism , Cell Differentiation , Osteoclasts/metabolism , RANK Ligand/metabolism
9.
Collagen-binding antibody prevents arthritis.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(12): 759, 2023 Dec.
Article in English | MEDLINE | ID: mdl-37848551

Subject(s)
Antibody Formation , Arthritis , Collagen , Animals , Humans , Antibodies , Arthritis/prevention & control , Autoimmunity
10.
Pre-exposure prophylaxis reduces risk of COVID-19.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(11): 677, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37789116

Subject(s)
COVID-19 , Pre-Exposure Prophylaxis , Humans , COVID-19/prevention & control , SARS-CoV-2
11.
SLC26A2 deficiency, matrix stiffness and mechanotransduction linked in osteoporosis.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(11): 677, 2023 Nov.
Article in English | MEDLINE | ID: mdl-37789117

Subject(s)
Mechanotransduction, Cellular , Osteoporosis , Humans , Extracellular Matrix , Sulfate Transporters
12.
SGLT2 inhibitors protect podocytes in lupus nephritis.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(10): 605, 2023 10.
Article in English | MEDLINE | ID: mdl-37666997

Subject(s)
Lupus Nephritis , Podocytes , Sodium-Glucose Transporter 2 Inhibitors , Humans , Sodium-Glucose Transporter 2 Inhibitors/pharmacology , Sodium-Glucose Transporter 2 Inhibitors/therapeutic use , Lupus Nephritis/drug therapy
13.
Interosseous tendon inflammation associated with arthritis risk.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(9): 538, 2023 09.
Article in English | MEDLINE | ID: mdl-37532783

Subject(s)
Arthritis , Inflammation , Humans , Inflammation/complications , Tendons , Arthritis/complications , Arthritis/epidemiology
14.
Aminoacyl-tRNA synthetases function as alarmins in RA.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(9): 538, 2023 09.
Article in English | MEDLINE | ID: mdl-37537377

Subject(s)
Alarmins , Amino Acyl-tRNA Synthetases , Humans , Amino Acyl-tRNA Synthetases/genetics , RNA, Transfer
15.
Low back pain is a growing concern.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(8): 462, 2023 08.
Article in English | MEDLINE | ID: mdl-37430106
16.
NETs implicated in periodontitis-associated bone loss.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(8): 463, 2023 08.
Article in English | MEDLINE | ID: mdl-37430108

Subject(s)
Extracellular Traps , Periodontitis , Humans , Periodontitis/complications
17.
Rheumatic diseases on the rise.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(7): 396, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37286759
18.
Antibodies cross-reactive with DNase1L3 and dsDNA discovered.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(6): 325, 2023 06.
Article in English | MEDLINE | ID: mdl-37165087

Subject(s)
DNA , Lupus Erythematosus, Systemic , Humans , Antibodies , Antibodies, Antinuclear , Endodeoxyribonucleases/genetics
19.
Targeting KDM2/7 histone demethylases could protect against OA.
Onuora, Sarah.
Nat Rev Rheumatol ; 19(6): 326, 2023 06.
Article in English | MEDLINE | ID: mdl-37165088

Subject(s)
Enzyme Inhibitors , Histone Demethylases , Humans
20.
Which DMARD for ICI-associated arthritis?
Onuora, Sarah.
Nat Rev Rheumatol ; 19(7): 395, 2023 Jul.
Article in English | MEDLINE | ID: mdl-37217610

Subject(s)
Antirheumatic Agents , Arthritis, Rheumatoid , Humans , Antirheumatic Agents/adverse effects , Arthritis, Rheumatoid/drug therapy
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