Aspectos intergeracionais de famílias em situação de violência / Intergerational aspects of families in situation of violence

A violência intrafamiliar, sendo considerada como um problema de saúde pública indica a necessidade de estudos e intervenções voltadas para mudanças na maneira de pensar e conduzir as relações entre as pessoas. Esta pesquisa consistiu em um estudo qualitativo com o objetivo de compreender os aspectos intergeracionais de famílias em situação de violência. Participaram doze famílias com filhos de um a dez anos. Utilizou-se um roteiro de entrevista elaborado para esta pesquisa, baseado em instrumentos sobre táticas de resolução de conflitos e sobre funcionamento familiar. A entrevista foi utilizada para a elaboração dos genogramas, abordando temas como conflitos conjugais e parentais, bem como a conjugalidade dos pais dos entrevistados e as práticas intergeracionais. Os genogramas foram construídos por meio do programa genopro. Os resultados apontaram que nas relações representadas houve episódios de conflitos, retratando a violência dentro daquele meio, sendo possível identificar a transmissão intergeracional da violência presente nestes casos.

Intrafamily violence, being considered a public health problem, indicates the need for studies and interventions aimed at changes in the way of thinking and conducting relationships between people. This research consisted of a qualitative study with the objective of understanding the intergenerational aspects of families in situations of violence. Twelve families with children from one to ten years participated. An interview script designed for this research was used, based on instruments on conflict resolution tactics and family functioning. The interview was used to prepare the genograms, addressing topics such as marital and parental conflicts, as well as the conjugality of the interviewees' parents and intergenerational practices. The genograms were constructed using the genopro program. The results showed that in the relationships represented, there were episodes of conflict, portraying violence within that environment, making it possible to identify the intergenerational transmission of violence present in these cases.

Cochineal carmine adsorbed on layered zinc hydroxide salt applied on mortadella to improve color stability.

The pink/reddish color meat products characteristic of cured meat without the curing salts is a meat industry demand to serve consumers who are looking for healthy foods with the usual sensory characteristics. This study aimed to obtain and characterize a hybrid dye and use it as a replacer for curing salt in the production of pink/red color in mortadella stored for 40 days. A layered zinc hydroxide salt (ZHN) was obtained by alkaline precipitation to immobilize and increase cochineal carmine stability, obtaining the hybrid dye (ZHN-carmine) by ion exchange in aqueous solution. The ZHN-carmine was subjected to ultrasound to increase color intensity and reduce the amount of application. ZHN, cochineal carmine and ZHN-carmine were characterized by X-Ray Diffraction, Fourier-Transform Infrared Spectroscopy, Thermogravimetric Analysis and Differential Scanning Calorimetry. The ZHN-carmine was used in the mortadella elaboration traditionally prepared with nitrite/nitrate and/or carmine. In the characterization it was observed that carmine dye was adsorbed on the lamellar compound surface and over the mortadella storage, it ensures a more stable pink/reddish color than the others product formulations. A more intense color with lower L* and higher a* values was observed for mortadella added of ZHN-carmine ultrasound-assisted. Therefore, the lamellar matrix adsorbed with cochineal carmine may a suitable and useful alternative to obtain the pink/reddish color characteristic of cooked meat products by applying a natural hybrid dye.

Safety and Efficacy of PCSK9 Inhibitors After Heart Transplantation.

Dyslipidemia is common in patients undergoing heart transplantation and is associated with the progression of cardiac allograft vasculopathy. Two monoclonal antibodies directed against PCSK9i-evolocumab and alirocumab-are currently available. However, their use, safety and efficacy in the post-transplant setting have not been studied. We present our experience with 6 heart transplant recipients treated with a PCSK9i. A > 70% reduction in LDL-cholesterol was observed after evolocumab therapy. PCSK9 inhibitors are a potentially lipid-lowering therapeutic option for heart transplant patients with suboptimal LDL despite maximal tolerated statin doses.

Risk evaluation using gene expression screening to monitor for acute cellular rejection in heart transplant recipients.

BACKGROUND: Gene expression profiling (GEP) was developed for non-invasive surveillance of acute cellular rejection. Despite its widespread use, there has been a paucity in outcome data for patients managed with GEP outside of clinical trials. METHODS: The Outcomes AlloMap Registry (OAR) is an observational, prospective, multicenter study including patients aged ≥ 15 years and ≥ 55 days post-cardiac transplant. Primary outcome was death and a composite outcome of hemodynamically significant rejection, graft dysfunction, retransplantation, or death. Secondary outcomes included readmission rates and development of coronary allograft vasculopathy and malignancies. RESULTS: The study included 1,504 patients, who were predominantly Caucasian (69%), male (74%), and aged 54.1 ± 12.9 years. The prevalence of moderate to severe acute cellular rejection (≥2R) was 2.0% from 2 to 6 months and 2.2% after 6 months. In the OAR there was no association between higher GEP scores and coronary allograft vasculopathy (p = 0.25), cancer (p = 0.16), or non-cytomegalovirus infection (p = 0.10). Survival at 1, 2, and 5 years post-transplant was 99%, 98%, and 94%, respectively. The composite outcome occurred in 103 patients during the follow-up period. GEP scores in dual-organ recipients (heart-kidney and heart-liver) were comparable to heart-alone recipients. CONCLUSIONS: This registry comprises the largest contemporary cohort of patients undergoing GEP for surveillance. Among patients selected for GEP surveillance, survival is excellent, and rates of acute rejection, graft dysfunction, readmission, and death are low.

Ovariosalpingohisterectomia vídeo-assistida ou convencional em cadelas com o uso de Ligasure atlas™ / Laparoscopic-assisted or open ovariohysterectomy using Ligasure atlas™ in dogs

Procurou-se comparar duas técnicas de ovariosalpingohisterectomia (OSH): vídeo-assistida com dois portais e convencional em cadelas, ambas com o uso de equipamento Ligasure atlas®. Para tanto, foram utilizados 18 animais separados em dois grupos, sendo no primeiro grupo realizada a OSH por celiotomia e no segundo pelo acesso vídeo-assistido. Os procedimentos videocirúrgicos foram realizados por meio de dois trocartes dispostos nas regiões umbilical e pré-púbica, com os cães posicionados em decúbito dorsal. Em ambos os grupos, o único método de hemostasia empregado foi o Ligasure atlas®. Não houve diferença significativa acerca do tempo operatório, das complicações trans e pós-operatórias e das perdas sanguíneas. Conclui-se que a OSH vídeo-assistida com o uso de dois portais e Ligasure atlas® e a técnica convencional com o emprego do mesmo equipamento são rápidas, seguras e efetivas em cadelas.

In this study the authors compared two different procedures of ovariosalpingohysterectomy (OSH) in dogs. For that, 18 dogs were randomly assigned into 2 different groups: group I (GI) in which the OSH was performed by celiotomy and group II (GII) in which it was a video-assisted procedure using two portals positioned in the umbilical and pre pubic regions, under dorsal recumbence position. In both groups the method of hemostasis was the Ligasure atlas®. The authors did not observe significant differences between both methods for the surgical time or complications during and after the surgical procedure and blood loss. It was concluded that OSH using video-assisted surgery with two portals and the conventional technique, both using Ligasure atlas® are safe, fast and effective to be used in dogs.