ABSTRACT
Resumen Se reporta una paciente en tratamiento con cloroquina para una artritis reumatoidea de aproximadamente diez años de evolución, con una importante dosis acumulada y en quien se documentó deterioro progresivo de la función renal, proteinuria en rango no nefrótico y compromiso muscular proximal en extremidades. En la biopsia renal se encontró a nivel de podocitos cuerpos de cebra. Se descartó enfermedad de Fabry. Se concluyó fosfolipidosis inducida por medicamentos en este caso por cloroquina. Este reporte de caso nos recuerda la importancia de conocer los posibles efectos colaterales de los medicamentos. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2192).
Abstract This is the report of a patient being treated with chloroquine for an approximately 10-year history of rheumatoid arthritis, with a significant cumulative dose and documented progressive kidney function deterioration, non-nephrotic proteinuria and involvement of the proximal muscles of the extremities. The kidney biopsy showed zebra bodies in the podocytes. Fabry disease was ruled out. Medication-induced phospholipidosis was diagnosed, in this case due to chloroquine. This case report reminds us of the importance of being aware of the possible side effects of medications. (Acta Med Colomb 2022; 47. DOI:https://doi.org/10.36104/amc.2022.2192).
ABSTRACT
RESUMEN COVID-19 tiene un espectro amplio de manifestaciones clínicas, se ha descrito lesión renal aguda con evidencia de necrosis tubular aguda y diversos tipos de podocitopatías. Se presenta el caso clínico de un paciente con trasplante renal y COVID-19 que debuta con lesión renal aguda y síndrome nefrótico. Proteína C-reactiva para síndrome respiratorio agudo severo 2 en hisopado nasal es positiva y en tejido renal es negativa. Biopsia renal reporta enfermedad de cambios mínimos. A la fecha es el primer reporte de esta podocitopatía asociada a COVID-19 en paciente con trasplante renal.
ABSTRACT COVID-19 disease is a systemic infection associated with renal damage leading to acute kidney injury with acute tubular necrosis and several types of podocytopathies. We report a clinical case in a kidney transplant patient diagnosed with COVID-19 disease, acute kidney injury and nephrotic syndrome. SARS-CoV 2 PCR results in nasal swab was positive and kidney was negative. Renal histopathologic findings described minimal change disease. So far, this case is the first clinical report of minimal change disease associated to COVID-19 in a kidney transplant patient.
ABSTRACT
Primary pleomorphic sarcoma of the left atrium is a rare tumor. There is no actual evidence of the management of this pathological entity, so the main treatment is individualized, surgical management being the cornerstone of the treatment. We present a 78-year-old female who had a clinical picture of heart failure, documenting an atrial mass of the left atrium, with high-grade pleomorphic sarcoma revealed in histopathology. The tumor was surgical removed, with no clinical evidence of residual mass. The tumor recurred again within 3 years, to which the patient succumbed.