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Bioorg Med Chem Lett
; 14(17): 4375-8, 2004 Sep 06.
Article
in English
| MEDLINE
| ID: mdl-15357956
ABSTRACT
A series of 3-substituted N,N'-diarylureas was prepared and the structure-activity relationship relative to CXCR2 receptor affinity as well as their pharmacokinetic properties were examined. In vitro microsomal metabolism studies indicated that the lower clearance rates of the 3-sulfonamido-substituted compounds were most likely due to the suppression of glucuronidation.