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BACKGROUND: Strongyloidiasis is a disease of great public health significance, caused by the parasitic nematodes Strongyloides stercoralis, Strongyloides fuelleborni, and Strongyloides fuelleborni subsp. kellyi. This systematic review and meta-analysis aimed to assess the prevalence of Strongyloides stercoralis infection in Peru. METHODS: The review was based on a literature search in PubMed, SciELO and Google Scholar using the key words or root words "strongyl*" AND "Peru" on 15 July 2020. Eligible studies were published from 1 January 1981 to 15 July 2020 and written in English, Spanish, Italian, or French. RESULTS: We included 21 papers in the analysis. Studies were heterogeneous in terms of study population and diagnostic methods (e.g. Baermann technique, agar, Dancescu or charcoal cultures, serology, string capsule). Prevalence of S. stercoralis ranged from 0.3 to 45%. The pooled proportion of Strongyloides in the general population was 7.34% (95% CI 4.97 to 10.13%). Half the studies were designed to detect parasites in general. In studies designed to detect S. stercoralis, the most widely used diagnostic method was the Baermann technique. CONCLUSION: Prevalence of S. stercoralis in Peru was high but varied by geographic area, techniques for stool examination, and participant characteristics.
Subject(s)
Strongyloides stercoralis , Strongyloidiasis , Animals , Feces , Humans , Peru/epidemiology , Prevalence , Strongyloidiasis/diagnosis , Strongyloidiasis/epidemiologyABSTRACT
Background. Human T-cell lymphotropic virus type 1 (HTLV-1) is responsible for tropical spastic paraparesis and HTLV-1-associated leukemia/lymphoma. The infection is endemic in some areas of Peru, but its prevalence in the Peruvian Amazon is not well established. We aimed to assess the seroprevalence of HTLV-1 infection in pregnant women in the Peruvian Amazon. Moreover, we performed a systematic literature review and meta-analysis of the seroprevalence of HTLV infection in Peru. (2) Methods. This is a prospective cross-sectional study involving pregnant women attending health centers in the city of Iquitos, Peru, in May and June 2019. The presence of antibodies against HTLV-1 was assessed using ELISA (HTLV I + II ELISA recombinant v.4.0, Wiener lab, Rosario, Argentina). Positive cases were confirmed by Western Blot and HTLV-1 proviral load. (3) Results. The study included 300 pregnant women with a mean age of 26 years (standard deviation [SD] 6.4). Five patients were diagnosed with HTLV-1 infection (prevalence 1.7%, 95% confidence interval (CI) 0.7% to 3.8%). Pregnant women with HTLV-1 infection were discretely younger (mean age 22.6 [SD 22.6] vs 26.8 [SD 6.3]; p = 0.128). None of the five women had been transfused, and all were asymptomatic. Two (40%) also had a positive serology for Strongyloides, but larvae were not detected in any of the parasitological stool studies. The systematic review component identified 40 studies, which showed that the prevalence of HTLV infection in the general population was 2.9% (95% CI 1.2% to 5.3%) and in women of childbearing age, 2.5% (95% CI 1.2% to 4.0%). (4) Conclusion. The prevalence of HTLV-1 in the Peruvian Amazon basin is about 1.7%, indicating an endemic presence. Screening for HTLV-1 in prenatal care is warranted.
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Aims: To assess the prevalence of Chagas disease in pregnant women in Iquitos City, Peru. Material and Methods: Cross-sectional survey in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using an ELISA serology test. Results: Serology was positive in one case (prevalence: 0.33%; 95% confidence interval: 7.1-13.9%), of a 25-year-old woman who lived in a wooden house with a leaf roof in a periurban area of Iquitos. She was familiar with kissing bugs and had chronic, asymptomatic Chagas disease. Conclusion: The prevalence of Chagas disease is low in the urban and peri-urban area of the city of Iquitos.
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Strongyloidiasis is a soil-transmitted helminthiasis with a high global prevalence. OBJECTIVES: We aimed to evaluate the prevalence of Strongyloides stercoralis infection and assess strongyloidiasis serology as a screening technique in the Peruvian Amazon. MATERIAL AND METHODS: We performed a cross-sectional study of strongyloidiasis in 300 pregnant women in Iquitos (Peru) from 1 May 2019 to 15 June 2019. Women were tested using serology (Strongyloides IgG IVD-ELISA kit) as an index test and the modified Baermann technique and/or charcoal fecal culture as the parasitological reference standard. RESULTS: The reference tests showed S. stercoralis in the stool of 30 women (prevalence: 10%; 95% confidence interval [CI] 7.1% to 13.9%), while 101 women tested positive on the blood test (prevalence: 33.7%; 95% CI 28.6% to 39.4%). Fourteen of the 15 women (93.3%) with positive results according to the modified Baermann technique, and 14 of the 23 women (56.5%) with positive charcoal cultures also had positive serological results. Serology showed a sensitivity of 63.3% and a negative predictive value of 94.4%. CONCLUSION: In Iquitos, pregnant women have a high prevalence of S stercoralis. S. stercoralis ELISA could be an excellent tool for population-based screening, as it has a high negative predictive value that can help to rule out the presence of active infection.
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AIM: To analyse differences in children and adolescents aged ≤18 years admitted to the leprosy ward in a rural Ethiopian hospital >16 years. METHODS: We retrospectively collected data from leprosy admission registry books on patients with leprosy who were admitted to a referral hospital from September 2000 to September 2016. RESULTS: There were 2129 admissions for leprosy during the study period: 180 (8.4%) patients were s ≤ 18 years old. Of these, 98 (54.4%) were male and 82 (45.6%) were female. The proportion of new diagnoses in children and adolescents was 31.7%, significantly higher than in adults (11.7%; p < 0.001). There were also significant differences in the prevalence of lepromatous ulcers (46.9 vs. 61.7%), leprosy reaction (29.4 vs. 13.0%) and neuritis (16.9 vs.5.3%) between these age groups. CONCLUSIONS: There were more new diagnoses, leprosy reactions and neuritis, and fewer lepromatous ulcers, in children and adolescents compared with adults, with younger patients being referred more frequently to reference centres.
Subject(s)
Hospitalization/statistics & numerical data , Length of Stay/statistics & numerical data , Leprosy/epidemiology , Adolescent , Adult , Age Distribution , Child , Child, Preschool , Ethiopia/epidemiology , Female , Hospitals, Rural/statistics & numerical data , Humans , Male , Middle Aged , Prevalence , Retrospective Studies , Sex DistributionABSTRACT
Introducción: El objetivo del estudio fue analizar las características clínico epidemiológicas y evolutivas de los de los pacientes ingresados en una sala de hospitalización específica de la lepra. Métodos: Recogida retrospectiva de datos de pacientes ingresados por lepra usando los libros de registro de admisión desde septiembre 2002 hasta septiembre 2016 en el Hospital General Rural de Gambo. Resultados: Durante el período de estudio hubo 2.134 ingresos en la sala de lepra; de ellos 1.386 (64,9%) fueron hombres, el ratio de admisiones hombres /mujeres fue 1,9. Ciento ochenta pacientes (8,4%) pacientes tenían 18 años o menos. El número de casos nuevos fue 287 (13,4%) frente a los antiguos casos 1.847 (86,6%). Mil setecientos ochenta y cuatro pacientes presentaban lepra multibacilar (83,6%). El principal diagnóstico durante el ingreso fueron úlceras de piel neuropáticas (n=1280; 60%). Otros diagnósticos por orden de frecuencia fueron leprorreacción (n=305; 14,3%) y neuropatía (n=132; 6,2%). La mediana de estancia en el hospital fue 58 días (recorrido intercuartílico: 31-96,5). La mayoría de los pacientes se recuperaron satisfactoriamente al alta 1.822 (84,9%). La mortalidad fue baja 1,7%. Conclusiones: La mayoría de los pacientes eran varones, que ingresaron en el curso de la enfermedad (en tratamiento o antiguos leprosos), la mayoría adultos y principalmente por ulceraciones
Introduction: The objective of the study was to analyze the clinical and evolutionary characteristics of the patients admitted to a specific hospitalization room for leprosy at the Hospital Rural of Gambo .Methods: Retrospective data collection of patients admitted for leprosy using the admission logbooks from September 2002 to September 2016 at the General Rural Hospital of Gambo. Results: During the study period, there were 2,134 admissions in the leprosy ward; there were 1,386 (64.9%) men, the ratio of admissions for men / women was 1.9. One hundred and eighty patients (8.4%) were 18 years or younger. The number of new cases was 287 (13.4%) compared to the old cases, 1,847 (86.6%). One thousand seven hundred and eighty four patients presented multibacillary leprosy (83.6%). The main diagnosis during admission was neuropathic skin ulcers (n = 1280; 60%). Other diagnoses in order of frequency were leprosy reactions (n = 305, 14.3%) and neuropathy (n = 132, 6.2%). The median hospital stay was 58 days (interquartile range: 31-96.5). The majority of the patients recovered satisfactorily at the 1822 discharge (84.9%). Mortality was low 1.7%. Conclusions: The majority of the patients were men, who entered the course of the disease (in treatment or old lepers), most of them adults and mainly ulcerations
