Long-term results of surgical treatment in Graves' disease orbitopathy. Is there a correlation between the extent of thyroidectomy and the course of orbithopathy?

UNLABELLED: The place of thyroidectomy in the management of the Graves' disease patients with endocrine orbitopathy (EO) is still controversial. The aim of this study was to evaluate the course of EO according to the extent of thyroid resection. METHODS: A retrospective cross-sectional study was performed on a series of 171 cases of Graves'disease, operated in the period 1987-2002 in the Department of Surgery of the Philipps University, Marburg. The severity of EO at the time of operation was assessed according to NOSPECS classification and a structured telephone interview was conducted in order to appraise the long term results. RESULTS: Complete data acquisition was possible in 153 patients (89%). There were 123 women with a median age of 36 years (range 10-75) and 30 men with a median age of 33 years (range 22-65). Concerning the severity of EO, 70 patients (45.8%) had no ocular symptoms (group I). The 83 patients with clinical eye disease were divided in group II--63 patients (76%) with moderate syndrome and group III--20 patients (24%) with marked symptoms of EO. 12 patients received total thyroidectomy, 96 had Dunhill-resection and in 45 patients subtotal resection was performed. A median follow-up period of 96 months (range 12-216 months) was recorded. Post-operatively, of the 83 patients with EO, 53 patients (63.8%) declared an improvement of EO, in 29 patients (34.9%) the disease was stable and only one patient declared the worsening of EO. The extent of thyroid resection did not correlate with the postoperative course of orbitopathy. CONCLUSION: Thyroid surgery for GD improves the course of EO, independent of the extent of resection.

Severe Graves' ophthalmopathy may be a risk factor for the development of postthyroidectomy hypocalcaemia.

PURPOSE: The aim of this study was to compare the rate of hypocalcaemia after thyroid resection in patients with versus patients without Graves' Ophthalmopathy (GO). PATIENTS AND METHODS: 153 patients following thyroid surgery for Grave's disease were studied. Patients were divided into three groups according to the severity of GO at the time of surgery using the NOSPECS classification. Subgroup I comprised of 70 patients without GO, subgroup II comprised of 63 patients with moderate GO and 20 patients with severe GO were assigned to Subgroup III. Association between severe ophthalmopathy and postoperative hypocalcaemia after thyroidectomy was investigated. RESULTS: 12/70 patients complained transient and 3/70 permanent hypocalcemia within subgroup I. 14/63 patients developed transient and 4/63 patients permanent hypocalcaemia within subgroup II. There were 7/20 patients with transient and 5/20 cases with permanent hypocalcaemia in the patient group with severe GO (subgroup III). The incidence of permanent postthyroidectomy hypocalcaemia was significantly higher in the subgroup III with severe GO when compared to the subgroup I without GO (p=0.004). CONCLUSION: Although postthyroidectomy hypocalcemia seems to be a multifactorial phenomenon, this study implicates unknown role of severe GO at time of surgery in the development of hypocalcaemia after thyroid surgery for Graves' disease. Therefore, patients with GO should be considered for surgery at high volume centres specialised in thyroid and parathyroid surgery.