ABSTRACT
PURPOSE: Nasopharyngeal carcinoma (NPC) is a malignant tumor endemic in southern China and Southeast Asia with a poor prognosis. Vascular cell adhesion protein 1 (VCAM-1) is highly expressed in NPC; however, it is unclear whether VCAM-1 is correlated with chemotherapy resistance and prognosis in NPC. PATIENTS AND METHODS: To further explore the role of VCAM-1 in chemotherapy resistance and prognosis in NPC, we examined the expression of VCAM-1, the sensitivity of chemotherapy drugs, and clinical follow-up data from 73 patients with NPC. Then, the results of VCAM-1 expression were analyzed in response to chemotherapy drugs, progression-free survival (PFS), and overall survival (OS). RESULTS: The expression of VCAM-1 protein in NPC was significantly higher than that in chronic inflammatory tissue. No significant differences in the expression of VCAM-1 among gender, age, pathologic classification, tumor classification, lymph node status, metastasis status, and overall clinical stage were found. The periods of PFS and OS in patients with high VCAM-1 expression were significantly shorter than those in patients with low VCAM-1 expression. The sensitivity rates of NPC to eight chemotherapy drugs were different; carboplatin and docetaxel showed the highest chemotherapy sensitivity and resistance rates, respectively. The resistance rates to paclitaxel were different between the patients with high VCAM-1 expression and those with low VCAM-1 expression. CONCLUSION: Our data indicated that VCAM-1 was highly expressed in NPC. Patients with high VCAM-1 expression were more prone to shorter periods of PFS and OS. VCAM-1 could be a prognostic marker of NPC patients. The detection of VCAM-1 expression in NPC may be valuable for chemotherapy drug evaluation and management of patients with NPC in the clinic.
ABSTRACT
To Study Juvenile xanthogranuloma (JXG) in the nasal cavity, raise the level of diagnosis and treatment for this disease. We reported a case with JXG and reviewed the literatures. JXG in nasal vestibule is ex tremely rare. Only three cases were reported before. After surgical removal,no recurrence was found over a 10-month follow-up. Clinical manifestations and imaging examination is nonspecific for JXG, and the diagnosis of the disease relies on pathological examination. Surgical resection is an effective treatment method.
Subject(s)
Nasal Cavity , Xanthogranuloma, Juvenile , Humans , Infant , MaleABSTRACT
OBJECTIVE: To study the relationship between negative life events and quality of life of tinnitus patients, and explore the role of negative life events in psychological counseling and rehabilitation of tinnitus. METHOD: Sixty-one cases of tinnitus patients and 61 normal controls were tested with tinnitus handicap inventory and life event scale, scores were compared and the associated analysis was made. RESULT: Stimulating quantity of negative life events in the tinnitus group, compared with the control group was statistically different (Z = -2.56. P < 0.05). The incidence of negative life events in the tinnitus group compared with the control group was no statistically different (chi2 = 0.05, P > 0.05). The incidence of abnormal scores of negative life events compared with the control group was statistically different (chi2 = 16.68, P < 0.01). Positive correlation in tinnitus group was found between scores of negative life events and scores of tinnitus handicap inventory (r = 0.41, P < 0.01). The higher the score of negative life events, the lower the quality of life with tinnitus patients. CONCLUSION: Severity of negative life events and tinnitus is closely related, and negative life events can reduce the quality of tinnitus patients life. We should pay more attention to negative life events in psychological counseling with tinnitus patients. The intervention in negative life events can improve the quality of life. providing the targeted and individualized theory basis for tinnitus psychological counseling and rehabilitation.
Subject(s)
Life Change Events , Quality of Life , Stress, Psychological , Tinnitus/psychology , Adolescent , Adult , Case-Control Studies , Female , Humans , Male , Middle Aged , Surveys and Questionnaires , Tinnitus/rehabilitation , Young AdultSubject(s)
Esophagus , Foreign Bodies/complications , Hoarseness/etiology , Aged , Foreign Bodies/diagnosis , Hoarseness/diagnosis , Humans , MaleABSTRACT
OBJECTIVE: To investigate the features of nasal septum cellule in computed tomographic (CT) images and its clinical significance. METHOD: CT scans data of nasal septum in 173 patients were randomly obtained from January 2001 to June 2005. Prevalence and clinical features were summarized in the data of 19 patients with nasal septum cellule retrospectively. RESULT: (1) Nineteen cases with nasal septum cellule were found in 173 patients. (2) All nasal septum cellule of 19 cases located in perpendicular plate of the ethmoid bone, in which 8 cases located in upper part of nasal septum and 11 located in middle. (3) There were totally seven patients with nasal diseases related to nasal septum cellule, in which 3 cases with inflammation, 2 cases with bone fracture, 1 case with cholesterol granuloma, 1 case with mucocele. CONCLUSION: Nasal septum cellule is an anatomic variation of nasal septum bone, and its features can provide further understanding of some diseases related to nasal septum cellule.