1.
Chem Commun (Camb)
; 51(6): 1112-5, 2015 Jan 21.
Article
in English
| MEDLINE
| ID: mdl-25461278
ABSTRACT
3-Aryltetrahydrobenzisoxazoles prepared en route to the coleophomone natural products and analogues, were found to undergo a remarkable base-mediated rearrangement to 2-aryltetrahydrobenzoxazoles. The scope of this unprecedented, facile transformation was probed: a range of analogues was produced, a mechanism proposed, and an application demonstrated by synthesis of a known herbicidal compound.
Subject(s)
Isoxazoles/chemistry , Oxazoles/chemistry , Crystallography, X-Ray , Heterocyclic Compounds, 4 or More Rings/chemistry , Molecular Structure
2.
Chem Commun (Camb)
; (3): 228-9, 2002 Feb 07.
Article
in English
| MEDLINE
| ID: mdl-12120378
ABSTRACT
Building block methodology from trifluoroethanol and ring-closing metathesis using a Fürstner modification of Grubbs' conditions allows the rapid synthesis of novel difluorinated cyclooctenones.