1.
Bioorg Med Chem Lett
; 22(17): 5445-50, 2012 Sep 01.
Article
in English
| MEDLINE
| ID: mdl-22863202
ABSTRACT
Using a parallel synthesis approach to target a non-conserved region of the PI3K catalytic domain a pan-PI3K inhibitor 1 was elaborated to provide alpha, delta and gamma isoform selective Class I PI3K inhibitors 21, 24, 26 and 27. The compounds had good cellular activity and were selective against protein kinases and other members of the PI3K superfamily including mTOR and DNA-PK.