Subject(s)
Chronic Urticaria , Urticaria , Case-Control Studies , Humans , Osteopontin , Urticaria/diagnosisABSTRACT
We report a retrospective analysis the efficacy of high-dose intravenous immunoglobulins on 9 patients with Livedoid vasculopathy for whom resistant to immunosuppressants plus anticoagulants or could not be prescribed. Intravenous immunoglobulins were used 2 g/kg per month in these patients. The treatment induced stabilization of the disease and all patients demonstrated improvement with IVIg. Complete and partial clinical response was achieved in 6 and 3 patients respectively.
Subject(s)
Livedo Reticularis , Vascular Diseases , Anticoagulants , Humans , Immunoglobulins, Intravenous , Livedo Reticularis/diagnosis , Livedo Reticularis/drug therapy , Retrospective StudiesABSTRACT
To analyze the effect of possible risk factors, including breastfeeding, on the development of childhood-onset psoriasis, a multicenter case-control study with prospective collection of data was performed. Using a standard questionnaire, personal and specific variables including family history of psoriasis, maternal and environmental tobacco smoke exposure, body mass index (BMI), exclusive and partial breastfeeding for at least 3 and 12 months, cow's milk intake before 1 year, birth delivery method, and stressful life events were collected during 2009 from 537 patients with psoriasis and 511 controls younger than 18. Overall, patients more frequently reported exposure to environmental tobacco smoke at home and stressful life events in the year preceding the diagnosis than controls. The odds ratios (OR) for smoking and stressful life events were 2.90 (95% confidence interval [CI]=2.27-3.78) and 2.94 (95% CI=2.28-3.79), respectively. In addition, children with psoriasis were more likely to have a higher BMI (>26) than controls (OR=2.52; 95% CI=1.42-4.49). High BMI, environmental tobacco smoke exposure at home, and stressful life events may influence the development of pediatric psoriasis.
Subject(s)
Environmental Exposure/statistics & numerical data , Psoriasis/epidemiology , Rural Population/statistics & numerical data , Urban Population/statistics & numerical data , Adolescent , Case-Control Studies , Child , Female , Humans , Life Change Events , Male , Risk Factors , Stress, Psychological/epidemiology , Surveys and Questionnaires , Tobacco Smoke Pollution/statistics & numerical data , Turkey/epidemiologyABSTRACT
Adverse effects of desensitization injections mostly consist of local transient reactions. Rarely, persistent subcutaneous nodular lesions may also develop at the site of injection. These reactions have been attributed to the vaccines containing aluminium hydroxide. Aluminium hydroxide is used as an adjuvant in vaccines and hyposensitization solutions. We describe a patient who presented persistent, itchy subcutaneous nodules as a local reaction to allergen immunotherapy for the treatment of allergic asthma.
