Treatment Strategies for Dopamine Agonist-Resistant and Aggressive Prolactinomas: A Comprehensive Analysis of the Literature.

Despite most of the prolactinomas can be treated with endocrine therapy and/or surgery, a significant percentage of these tumors can be resistant to endocrine treatments and/or recur with prominent invasion into the surrounding anatomical structures. Hence, clinical, pathological, and molecular definitions of aggressive prolactinomas are important to guide for classical and novel treatment modalities. In this review, we aimed to define molecular endocrinological features of dopamine agonist-resistant and aggressive prolactinomas for designing future multimodality treatments. Besides surgery, temozolomide chemotherapy and radiotherapy, peptide receptor radionuclide therapy, estrogen pathway modulators, progesterone antagonists or agonists, mTOR/akt inhibitors, pasireotide, gefitinib/lapatinib, everolimus, and metformin are tested in preclinical models, anecdotal cases, and in small case series. Moreover, chorionic gonadotropin, gonadotropin releasing hormone, TGFß and PRDM2 may seem like possible future targets for managing aggressive prolactinomas. Lastly, we discussed our management of a unique prolactinoma case by asking which tumors' proliferative index (Ki67) increased from 5-6% to 26% in two subsequent surgeries performed in a 2-year period, exerted massive invasive growth, and secreted huge levels of prolactin leading up to levels of 1 605 671 ng/dl in blood.

Could isthmic approach to far lateral disc hernias cause instability?

BACKGROUND: The aim of this study is to investigate the relationship between the degree of instability and the amount of isthmus excised during transpars (isthmic) approach which is accomplished with partial resection of the pars interarticularis used in distal lateral disc herniation. METHODS: Thirty-six ovine lumbar spine segments were used in the study. 25% and 50% of the right side isthmus of each spinal segment were excised. Flexion, lateral bending and axial rotation tests were performed in both groups. FINDINGS: There was no statistically significant difference found between the groups for yield moment, stiffness and ultimate load in flexion tests (p = 0.262, p = 0.749 and p = 0.200, respectively). Statistically significant difference was found between the groups for yield moment, stiffness and maximum load in lateral bending tests (p = 0.016, p = 0.010 and p = 0.016, respectively). There was no statistical difference found between the groups for yield torque and stiffness in axial rotation tests (p = 0.855 and p = 0.314). INTERPRETATION: These results show that a significant loss of resistance especially during the lateral bending loading was occurred with increasing resection portion of isthmus. With the load applied during the lateral bending of the pars interarticularis, the vertebra resected by 50% percent fractured significantly easier in comparison to the vertebra resected by 25% percent. Pars interarticularis is an important structure with an important role in stability. It is presumed that the more defect is created during the drill-up of the pars interarticularis, the more instability will be occurred.