ABSTRACT
Resistance training (RT) and n-3 polyunsaturated fatty acids (n-3 PUFA) supplementation have emerged as strategies to improve muscle function in older adults. Overweight/obese postmenopausal women (55-70 years) were randomly allocated to one of four experimental groups, receiving placebo (olive oil) or docosahexaenoic acid (DHA)-rich n-3 PUFA supplementation alone or in combination with a supervised RT-program for 16 weeks. At baseline and at end of the trial, body composition, anthropometrical measures, blood pressure and serum glucose and lipid biomarkers were analyzed. Oral glucose tolerance tests (OGTT) and strength tests were also performed. All groups exhibit a similar moderate reduction in body weight and fat mass, but the RT-groups maintained bone mineral content, increased upper limbs lean mass, decreased lower limbs fat mass, and increased muscle strength and quality compared to untrained-groups. The RT-program also improved glucose tolerance (lowering the OGTT incremental area under the curve). The DHA-rich supplementation lowered diastolic blood pressure and circulating triglycerides and increased muscle quality in lower limbs. In conclusion, 16-week RT-program improved segmented body composition, bone mineral content, and glucose tolerance, while the DHA-rich supplement had beneficial effects on cardiovascular health markers in overweight/obese postmenopausal women. No synergistic effects were observed for DHA supplementation and RT-program combination.
Subject(s)
Body Composition , Cardiometabolic Risk Factors , Docosahexaenoic Acids/administration & dosage , Overweight/therapy , Postmenopause , Resistance Training , Aged , Blood Glucose/analysis , Dietary Supplements , Double-Blind Method , Fatty Acids, Omega-3/administration & dosage , Female , Glucose Tolerance Test , Humans , Lipid Metabolism , Middle Aged , Muscle Strength , Obesity/physiopathology , Obesity/therapy , Overweight/physiopathology , PlacebosABSTRACT
Short-chain carbohydrates and sugar alcohols are poorly absorbed in the small intestine and rapidly fermented by bacteria. Fermentable oligo-, di-, monosaccharides and polyols (FODMAP) content of a wide range of foods has been measured. However, the list of foods allowed, as well as the quantities of FODMAP each food differ between studies, making the management of the low FODMAP diet difficult.The aim of this research was to propose a FODMAP diet guide culturally adapted to different Hispanic countries for dietitians-nutritionists and nutrition experts, to facilitate the management of patients who benefit from this diet.A consortium of FODMAP diet experts was created among Spanish-speaking countries. Dieticians from 11 Latin American countries (Argentina, Colombia, Ecuador, El Salvador, Guatemala, Honduras, Mexico, Panama, Peru, Uruguay and Venezuela) and Spain elaborated a low FODMAP diet adjusted each to the gastronomic culture of their own country. They also created a list of foods to be reintroduced in phase 2 (or reintroduction phase) of the FODMAP diet, along with typical recipes from the country.Twelve low FODMAP diets with their corresponding reintroduction phase were designed, each adapted to the commonly consumed foods and recipes of each country. The adaptation of the diet to local gastronomy is pertinent, as it may increase the likelihood of durable adherence and better response to symptomatology.There are limitations in developing tables of FODMAP-rich and FODMAP-poor foods. The cut-off levels of FODMAP content are not clearly defined. More studies are needed to reach a unified consensus, as inconsistency in the data provided between studies has been found in relation to the FODMAP diet.(AU)
Los carbohidratos de cadena corta y los alcoholes de azúcar se absorben mal en el intestino delgado y las bacterias los fermentan rápidamente. Se ha medido el contenido de oligo, di, monosacáridos y polioles fermentables (FODMAP) de una amplia gama de alimentos. Sin embargo, la lista de alimentos permitidos, así como las cantidades de FODMAP de cada alimento, difieren entre estudios, lo que dificulta el manejo de la dieta baja en FODMAP.El objetivo de esta investigación fue proponer una guía dietética FODMAP adaptada culturalmente a diferentes países hispanos para facilitar a dietistas-nutricionistas y expertos en nutrición el manejo de los pacientes que se benefician de la dieta baja en FODMAP.Se creó un consorcio de expertos en dieta FODMAP entre países de habla hispana. Dietistas de 11 países latinoamericanos (Argentina, Colombia, Ecuador, El Salvador, Guatemala, Honduras, México, Panamá, Perú, Uruguay y Venezuela) y España elaboraron una dieta baja en FODMAP ajustada cada una a la cultura gastronómica del país. También crearon una lista de alimentos para ser reintroducidos en la fase 2 (o fase de reintroducción) de la dieta FODMAP, junto con recetas típicas del país.Se diseñaron doce dietas bajas en FODMAP con su correspondiente fase de reintroducción, cada una adaptada a los alimentos y recetas de consumo común de cada país. La adaptación de la dieta a la gastronomía local fue pertinente, ya que puede aumentar la adherencia a la dieta y una mejor respuesta a la sintomatología.Existen limitaciones en el desarrollo de tablas de alimentos ricos y pobres en FODMAP. Los niveles de corte del contenido de FODMAP no están claramente definidos. Se necesitan más estudios para alcanzar un consenso unificado, ya que se ha encontrado inconsistencia en los datos proporcionados en estudios relacionados con la dieta FODMAP.(AU)
Subject(s)
Humans , Male , Female , Diet, Food, and Nutrition , Diet, Healthy , Diet Therapy , Cultural Characteristics , Diet, Carbohydrate-Restricted , Spain , 52503 , Culture , Latin AmericaABSTRACT
Aging is a complex phenomenon characterized by the progressive loss of tissue and organ function. The oxidative-stress theory of aging postulates that age-associated functional losses are due to the accumulation of ROS-induced damage. Liver function impairment and non-alcoholic fatty liver disease (NAFLD) are common among the elderly. NAFLD can progress to non-alcoholic steatohepatitis (NASH) and evolve to hepatic cirrhosis or hepatic carcinoma. Oxidative stress, lipotoxicity, and inflammation play a key role in the progression of NAFLD. A growing body of evidence supports the therapeutic potential of omega-3 polyunsaturated fatty acids (n-3 PUFA), mainly docosahaexenoic (DHA) and eicosapentaenoic acid (EPA), on metabolic diseases based on their antioxidant and anti-inflammatory properties. Here, we performed a systematic review of clinical trials analyzing the efficacy of n-3 PUFA on both systemic oxidative stress and on NAFLD/NASH features in adults. As a matter of fact, it remains controversial whether n-3 PUFA are effective to counteract oxidative stress. On the other hand, data suggest that n-3 PUFA supplementation may be effective in the early stages of NAFLD, but not in patients with more severe NAFLD or NASH. Future perspectives and relevant aspects that should be considered when planning new randomized controlled trials are also discussed.
