Citrobacter koseri. Una endoftalmitis exógena inusual / Citrobacter koseri, an unusual exogenous endoftalmitis

Citrobacter koseri es un bacilo gramnegativo que causa endoftalmitis de forma muy infrecuente y agresiva, asociando mal pronóstico visual. Solo el 6% de las endoftalmitis son por gramnegativos y nuestro germen representa un pequeño porcentaje. Presentamos un varón de 65 años que trabaja en un laboratorio de animales. Acude a urgencias por pérdida de visión del ojo izquierdo debido a una hemorragia vítrea y desprendimiento de retina. Se practica una vitrectomía y 3 días después, desarrolla una endoftalmitis. Se realiza tratamiento intravítreo con inyecciones de vancomicina y ceftazidima así como tratamiento antibiótico tópico. Veinticuatro horas después, regresa con perforación corneal y una extrusión del cristalino. Ante la gravedad del cuadro se realiza una evisceración. El cultivo de las muestras confirman el microorganismo. Suponemos que la puerta de entrada del germen fueron las esclerotomías por el material de sutura expuesto, tras la manipulación de heces de roedores.(AU)

Citrobacter koseri is a bacillus that causes infrequent endophthalmitis. Six percent of cultures in endophthalmitis are Gram -, and as in these, Citrobacter koseri is associated with a poor visual prognosis. We present a 65-year-old man who works in an animal laboratory. He went to emergencies with loss of vision in his left eye due to a vitreous hemorrhage. A vitrectomy was performed and 3 days later, endophthalmitis was diagnosed. Vancomycin and ceftazidime were applied in eye drops and in two intravitreal injections. Twenty-four hours later he returned with a lens extrusion. Due to the severity of the condition, an evisceration was performed. Subsequently, the samples confirm the microorganism. We assume that the entry point for the bacterium was the sclerotomies through the exposed suture material, after handling rodent feces.(AU)

Citrobacter koseri, an unusual exogenous endoftalmitis.

Citrobacter koseri is a bacillus that causes infrequent endophthalmitis. 6% of cultures in endophthalmitis are Gram -, and as in these, C. koseri is associated with a poor visual prognosis. We present a 65-year-old man who works in an animal laboratory. He went to emergencies with loss of vision in his left eye due to a vitreous hemorrhage. A vitrectomy was performed and 3 days later, endophthalmitis was diagnosed. Vancomycin and Ceftazidime were applied in eye drops and in two intravitreal injections. 24 h later he returned with a lens extrusion. Due to the severity of the condition, an evisceration was performed. Subsequently, the samples confirm the microorganism. We assume that the entry point for the bacterium was the sclerotomies through the exposed suture material, after handling rodent feces.

Management of conjunctival perforation and late Seidel after XEN® surgery. / Manejo de la perforación conjuntival y Seidel tardío poscirugía XEN®.

CLINICAL CASE: The case concerns a 78 year-old woman with a history of XEN® surgery, in whom a conjunctival perforation was observed at the implant level at 18-months of follow-up, for which surgical intervention was decided. During surgery a short subconjunctival portion was found (0.5mm). An unsuccessful attempt was made to extract it by traction, but the XEN® broke easily. Finally, it was decided to cut it to scleral level, and suture the conjunctiva. During the first week there was a decrease in intraocular pressure (6mmHg), to subsequently increase to 25, and deciding to start medical treatment. DISCUSSION: Conjunctival exposure of the XEN® stent is a rare but potentially serious complication. To avoid it, a meticulous surgical technique is important when implanting it. If this occurs, it is important to identify the cause. If it is due to a short subconjunctival portion, a therapeutic alternative is to cut the implant at this level to avoid further complications.

Efficacy of the SENSIMED Triggerfish® in the postoperative follow-up of PHACO-ExPRESS combined surgery. / Eficacia del SENSIMED Triggerfish® para el seguimiento postoperatorio de la cirugía combinada FACO-ExPRESS.

OBJECTIVE: To determine the usefulness of the SENSIMED Triggerfish® system in the postoperative control of combined phacoemulsification and ExPRESS implant (PHACO-ExPRESS) surgery in patients with cataract and chronic open angle glaucoma (COAG) during a 2 months follow-up. METHODS: A prospective study conducted on 15 eyes that were subjected to PHACO-ExPRESS combined surgery. Using the SENSIMED Triggerfish® system, two records of the circadian patterns of intraocular pressure (IOP) were performed, one before and one after surgery. A record was made of the best corrected visual acuity (BCVA), comorbidities, previous IOP, and 7-30-60 days after surgery, as well as any hypotensive drugs and complications. RESULTS: The final sample was 12 eyes. The mean pre-operative BCVA (log MAR chart) before surgery was 0.5±0.2, and after surgery 0.14±0.1 (P=.02). The previous IOP was 18.7±3.8mmHg with 2.9±0.7 drugs. The mean IOP at 7, 30, and 60 days after surgery decreased to 13±4.1mmHg (P=.002), 13.5±2mmHg (P=.001), and 13.9±2.5mmHg (P=.001), respectively. The amplitudes of the circadian curves changed significantly after surgery (P=.007). The mean values between daytime and night-time periods decreased significantly from 146.8±80.9 mVeq and 61.2±92.mVeq before surgery to 36.4±36 mVeq (P=.000), and -23,2±47.6mVeq (P=.014) after surgery, respectively. There were complications in one patient. CONCLUSIONS: The SENSIMED Triggerfish® monitoring system showed changes in the curves of the circadian patterns, as well as decreased mean amplitudes after the combined PHACO-ExPRESS technique, suggesting that it may become a useful tool for postoperative follow-up of COAG.

Prospective study of filtering blebs after XEN45 surgery. / Estudio prospectivo de las ampollas de filtración poscirugía de implante XEN45.

OBJECTIVE: To qualitatively analyse the evolution of filtering blebs after XEN surgery, by using anterior segment optical coherence tomography (AS-OCT). METHODS: A prospective study was performed on filtering blebs of 30 eyes with cataracts and glaucoma, surgically operated on using phacoemulsification and XEN45 implantation (PHACO-XEN). AS-OCT was used to analyse bleb morphology and reflectivity at 3, 6, and 12 months after surgery. Functionality was studied considering an intraocular pressure (IOP)≤18mmHg without antihypertensive medication. RESULTS: The IOP enabled the blebs to be classified into non-functional: flat (6.67%) and encapsulated (3.33%); and functional (90%), which were then divide by their morphology into cystic (5/27), diffuse (2/27), and layered (20/27). Cystic types had a mean IOP of 12.8, 12.6, and 14.0mmHg at 3, 6 and 12 months, respectively. In the diffuse type, the mean IOP was 13.0, 11.5 and 13.0mmHg at 3, 6 and 12 months, respectively. In the layers pattern the mean IOP was 14.45, 14.55 and 14.8mmHg at 3, 6 and 12 months respectively. The percentage of blebs with high reflectivity was 48.15%, 62.96%, and 77.78%, at 3, 6 and 12 months, with a mean IOP of 14.23, 14.59, and 15.14mmHg in each time period, respectively. CONCLUSION: AS-OCT could be a good predictor of bleb functionality in PHACO-XEN surgery. Those with a cystic pattern or low reflectivity seem to have better post-operative success. Nevertheless, more long-term studies are required.

Qualitative analysis of repaired filtering blebs with anterior segment-optical coherence tomography. / Análisis cualitativo de ampollas de filtración reparadas mediante tomografía de coherencia óptica de segmento anterior.

OBJECTIVE: To provide a qualitative analysis of filtering blebs after being surgically repaired due to late blebs leaks. METHODS: Blebs were studied 6 months after surgical reparation using AS-OCT Triton (Topcon®). An analysis was made of the morphological pattern and internal structures of blebs, including the covering, in 10 patients. The images were obtained using OCTs at a wavelength of 1050nm. RESULTS: According to the Hirooka classification, three different patterns were found in the structure of blebs, which made it possible to correlate them with their functionality. A full covering was observed in 70% of the cases, and they showed sub-epithelial cysts (cystoid pattern). Two cases showed a full conjunctival retraction without Tenon's covering. The walls were thin, with a de-structured bleb (diffuse pattern) being visualised. In the third group, the image showed a partial conjunctival retraction with Tenon's covering. There were some sub-epithelial diffuse cysts with walls following a laminar pattern. CONCLUSION: Using AS-OCT, it is possible to study the bleb's characteristics in detail, as well as the cover, in the case of blebs requiring repair due to late leaks, using conjunctival advancement. It allows for the early visualisation of conjunctival retractions that were not visible in a slit lamp, and to predict the functionality of the blebs by their morphology.

Combined phacoemulsification and XEN45 surgery from a temporal approach and 2 incisions. / Cirugía combinada mediante facoemulsificación e implante XEN45 con acceso temporal y 2 únicas incisiones.

OBJECTIVE: To assess the safety and effectiveness of phacoemulsification combined with XEN45 implant surgery in patients with cataract and open-angle glaucoma, with 12-month follow-up. METHODS: A prospective study conducted on 30 eyes requiring phacoemulsification with, at least, 2 medications to control intraocular pressure (IOP). Phacoemulsification combined with XEN45 implant surgery was performed within 15minutes of administering subconjunctival mitomycin C. Surgery was performed through 2 temporal incisions, separated by 90°, using the inferior to enter the XEN45 and to implant it in the superior nasal region. A record was made of the best corrected visual acuity, IOP before and 1 day, 1 month, 3 months, 6 months, 9 months, and 12 months after surgery, the number of antiglaucomatous medications, and complications. RESULTS: The best corrected visual acuity was 0.37±0.2 and 0.72±0.15 before and 12 months after surgery, respectively. The pre-operative IOP was 21.2±3.4mmHg, with 3.07 drugs, decreasing by 61.65% on the first day, 37.26% at 1 month, 35.05% at 3 months, 31% at 6 months, 30.6% at 9 months, and 29.34% at 12 months. The number of medications decreased by 94.57%. Complications occurred in 3 eyes, 2 of them were excluded because we could not complete the implantation (280° subconjunctival haemorrhage and XEN extrusion when trying to reposition). In a third case, the bleb was encapsulated at 5 months after surgery. CONCLUSIONS: The phacoemulsification combined with XEN45 implant surgery can effectively reduce IOP and the number of drugs in mild-moderate open-angle glaucoma, as they rehabilitate the VA. The use of only 2 micro-invasive incisions makes it simple, quick and safe, with few complications at 12 months follow-up from surgery.

[Assessment of ophthalmologic control of the diabetic patient in primary care]. / Evaluación del control oftalmológico del paciente diabético en atención primaria.

OBJECTIVE: To evaluate ophthalmic control in patients with diabetes mellitus (DM) in primary care (PC). DESIGN: Crossover observation study. SETTING: Hellín Health Centre (Albacete). PATIENTS: 137 diabetics selected at random, excluding pregnant women and children under 14. MEASUREMENTS AND MAIN RESULTS: The variables of age, sex, type of diabetes (DM1/DM2), years of evolution, ophthalmic control and appearance of diabetic retinopathy (DR) were studied. Mean age was 68.5 +/- 10.9 years. 52% were women (n = 72). 88% had DM2 (n = 121). Time of evolution from diagnosis was < 5 years in 46% (n = 63), 6-10 years in 23% (n = 32), 11-15 years in 14% (n = 19), > 15 years in 5% (n = 7) and nothing was recorded for 12% (n = 16). 41% (n = 56) of the patients had not had an ophthalmic evaluation. Of the 59% (n = 81) referred to the ophthalmology out-clinic (OOC), 65 patients followed recommendations of the Spanish Society of Retina and Vitreous Humour, and 16 were referred for other reasons, of which cataracts was the most common eye pathology. Of these 81 patients referred to the OOC, 29% did not have DR (n = 23), and 44% did (n = 36). Of this 44%, 14 were light, 15 moderate, 3 severe and 4 proliferating cases. The reports were not sent back to PC in 27% of cases (n = 22). CONCLUSIONS: Ophthalmic referral in PC is still deficient for a large number of DM patients. DR of varying degrees was detected in a high number of cases who did have an ophthalmic check-up. Communication between PC and ophthalmic care concerning diabetic patients must improve.

Comparison of intersecting trapezoidal keratotomy and arcuate transverse keratotomy in the correction of high astigmatism.

BACKGROUND: High astigmatism can be corrected using trapezoidal or arcuate transverse keratotomies. Videokeratography enables qualitative evaluation of the corneal topography. METHODS: Fifty-five eyes of 41 patients presenting with high astigmatism after penetrating keratoplasty or naturally occurring astigmatism (mean, 6.29 diopters [D]; range, 3.00 to 16.00 D) underwent correction using either intersecting trapezoidal or arcuate transverse keratotomies. Corneal topographic maps were analyzed and classified into keratographic patterns. Mean follow up was 3 years (range, 1 to 6 years). RESULTS: The mean net decrease in refractive astigmatism was 3.60 D (52.7% reduction). The flattening/steepening ratio was on average higher for intersecting trapezoidal keratotomy (7.26 for astigmatism after penetrating keratoplasty and 8.31 for naturally occurring astigmatism) than for arcuate transverse keratotomy (.98 in astigmatism after penetrating keratoplasty and 1.76 in naturally occurring astigmatism). Accordingly, intersecting trapezoidal keratotomy tended to produce a hyperopic shift in the spherical equivalent refraction (mean hyperopic shift, 2.65 and .56 D, respectively). The mean vector-corrected change of refractive astigmatism after intersecting trapezoidal keratotomy was 88.8% in naturally occurring (n = 21 eyes) and 70.3% in penetrating keratoplasty astigmatism (n = 13). Arcuate transverse incisions corrected on average 79.9% of naturally occurring (n = 13) and 60.8% of penetrating keratoplasty astigmatism (n = 8). Videokeratography showed the asymmetric bowtie pattern as the most frequent pattern for both procedures. Intersecting trapezoidal keratotomy was characterized by relatively higher incidences of polygonal and irregular patterns. Arcuate transverse incisions caused less wound healing defects and glare than intersecting trapezoidal keratotomy. CONCLUSIONS: Both intersecting trapezoidal keratotomy and arcuate transverse incisions effectively reduced high naturally occurring astigmatism and astigmatism after penetrating keratoplasty. However, greater corneal surface irregularity and more complications were seen following intersecting trapezoidal keratotomy. Trapezoidal keratotomy should not be used unless a large decrease of myopia is needed, and then a nonintersecting technique is preferable.

Digital system measurement of decentration of Worst-Fechner iris claw myopia intraocular lens.

BACKGROUND: Topography measures the centration in refractive and corneal refractive surgery, but until recently there was no effective method to measure decentration in intraocular lens (IOL) implantation. PATIENTS AND METHODS: We measured the decentration of 22 phakic eyes, in 14 high myopic patients, based upon photographs of the anterior segment using a digital analysis system (IMAGEnet Topcon Corporation 1988, Tokyo, Japan). These eyes had undergone IOL implantation for the correction of myopia with Worst-Fechner iris claw lenses. Decentration was measured with respect to the centers of both the cornea and pupil. RESULTS: Mean decentration of the IOL center from the cornea center was 0.51 +/- 0.25 mm (range, 0 to 0.8374 mm). When measured with respect to the center of the pupil, the average decentration was 0.47 +/- 0.29 mm (range, 0.182 to 0.9341 mm). A positive correlation between the decentration measurements of the two methods was found (p < .01 indicated statistical significance). CONCLUSIONS: This digital imaging system (IMAGEnet) accurately measured decentration of IOLs in myopic eyes.