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1.
Perionews ; 9(2): 165-170, mar.-abr. 2015.
Article in Portuguese | LILACS | ID: lil-764874

ABSTRACT

Alteração periodontal foi descrita após a radioterapia de cabeça e pescoço para o tratamento de carcinomas. No entanto, não se sabe se os pacientes submetidos à manutenção periodontal também mostram destruição periodontal. A incidência de destruição periodontal após a radioterapia de cabeça e pescoço foi avaliada em pacientes submetidos à manutenção periodontal. Descrição do caso: profundidade de sondagem (PS), nível clínico de inserção (NCI), recessão gengival (RG), índice de placa (IP), sangramento à sondagem (SS) e nível do osso alveolar (NOA) foram avaliados em seis pacientes em manutenção periodontal, antes e sete meses após a terapia de radiação. Observou-se aumento significativo na recessão gengival (de 0,6 mm a 0,8 mm; p=0,001) e redução no nível ósseo (de 6,1 mm a 7,0mm; p=0,05). Mudanças no NCI e PS não foram significativas (p > 0,05). Implicações clínicas: aumento da recessão gengival e perda óssea alveolar foram observados nos pacientes submetidos à radioterapia de cabeça e pescoço sob manutenção periodontal. Portanto, em pacientes submetidos à manutenção periodontal, alterações periodontais também podem ser esperadas com a radioterapia de cabeça e pescoço.


Subject(s)
Carcinoma, Squamous Cell , Oropharyngeal Neoplasms , Periodontal Diseases , Periodontics , Radiotherapy
2.
J Periodontol ; 79(2): 300-6, 2008 Feb.
Article in English | MEDLINE | ID: mdl-18251644

ABSTRACT

BACKGROUND: This study evaluated the effects of diclofenac sodium and meloxicam on peri-implant bone healing. METHODS: Thirty male rats were divided into three groups: the control group (CG) received no drug; the diclofenac sodium group (DSG) received 1.07 mg/kg twice a day for 5 days; and the meloxicam group (MG) received 0.2 mg/kg daily for 5 days. A screw-shaped titanium implant was placed in the tibia. Fluorochromes, oxytetracycline (OxT), calcein (CA), and alizarin (AL), were injected at 7, 14, and 21 days, respectively, after implantation, and the animals were sacrificed 28 days after implant placement. The percentages of OxT-, CA-, and AL-labeled bone as well as the percentages of bone-to-implant contact (BIC), cortical bone area (CBA), and trabecular bone area (TBA) within the implant threads were evaluated. RESULTS: Bone healing was delayed in the DSG during the first 14 days after implant placement (OxT-labeled bone: DSG: 5.3% +/- 7.3% versus CG: 13.2% +/- 9.8%, P = 0.002, and versus MG:14.4% +/- 13.1%, P = 0.05). The percentages of BIC (DSG: 49.6% +/- 21.9%; MG: 67.1% +/- 22.8%; and CG: 68.1% +/- 22.8%) and CBA (DSG: 63.7% +/- 21.2%; MG: 82.7% +/- 12.4%; CG: 84.9% +/- 10.6%) were lower in the DSG compared to the MG and CG (P <0.001). The percentage of TBA was significantly greater in the DSG compared to the MG and CG (DSG: 36.3% +/- 21.2% versus MG: 17.3% +/- 12.7% and versus CG: 15.1% +/- 10.6%; P <0.001). CONCLUSION: Diclofenac sodium seemed to delay peri-implant bone healing and to decrease BIC, whereas meloxicam had no negative effect on peri-implant bone healing.


Subject(s)
Anti-Inflammatory Agents, Non-Steroidal/adverse effects , Dental Implants , Diclofenac/adverse effects , Osseointegration/drug effects , Osteogenesis/drug effects , Thiazines/pharmacology , Thiazoles/pharmacology , Animals , Anti-Inflammatory Agents, Non-Steroidal/pharmacology , Fluorescent Dyes , Implants, Experimental , Male , Meloxicam , Rats , Rats, Sprague-Dawley , Statistics, Nonparametric , Tibia/surgery , Wound Healing/drug effects
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