ABSTRACT
Annular elastolytic giant cell granuloma (AEGCG) is a rare granulomatous skin disease characterized clinically by annular plaques with elevated borders and atrophic centers found mainly on sun-exposed skin and histologically by diffuse granulomatous infiltrates composed of multinucleated giant cells, histiocytes and lymphocytes in the dermis along with phagocytosis of elastic fibers by multinucleated giant cells. We report a case of AEGCG in a 50-year-old woman and is highlighted for the classical clinical and histological findings of the disease and its rare co-existence with Hashimoto's thyroiditis.
ABSTRACT
Myxoid tumors are a heterogeneous group of lesions characterized by a marked abundance of extra cellular mucoid (myxoid) matrix.[1] The term aggressive emphasizes the often infiltrative nature of the tumor and its frequent association with recurrence.[2] A case of aggressive angiomyxoma arising from the vagina in a 55-year-old woman is reported for its rarity.
ABSTRACT
Lichen sclerosus (LS) is a chronic inflammatory disorder of an unknown aetiology most commonly affecting the anogenital area. However, extragenital involvement also occurs uncommonly. A case of extra-genital LS involving the areolae of both breasts, in a 15-year-old boy, is reported for its rarity.
ABSTRACT
An in-transit metastasis is one that is located between the primary tumor and the closest lymph node region and results from tumor emboli getting trapped in the lymphatic channels. A 65-year-old male patient who had undergone partial amputation of the penis and bilateral inguinal lymph node resection for squamous cell carcinoma of the penis 4 months earlier developed multiple cutaneous metastatic lesions in the pubic region and scrotum. The case is reported for the uncommon presentation of in-transit metastases.
ABSTRACT
Tuberculosis continues to be an important public health problem and cutaneous tuberculosis constitutes a minor proportion of extra pulmonary manifestations of tuberculosis. Elephantiasis of the external genitalia, as a sequel to cutaneous tuberculosis, in a 40-year-old diabetic lady is being reported for its rarity. The patient also had lesions of healed scrofuloderma of 27 years' duration, in both axillae, with residual pedunculated nodules.
ABSTRACT
Tuberculosis is a major public health problem in both developing and developed countries. Cutaneous Tuberculosis constitutes a minor proportion of extra-pulmonary manifestations of Tuberculosis. Lupus Vulgaris (LV) is one of the clinical variants of Cutaneous Tuberculosis. A case of a large plaque type psoriasiform lesion of lupus vulgaris on the thigh, of 15 years' duration, in an 18-year-old girl is reported. This case highlights the ignorance level among the patients and consequent failure to avail proper anti-tuberculous treatment despite campaign in print and audio visual media.
Subject(s)
Lupus Vulgaris/diagnosis , Lupus Vulgaris/drug therapy , Adolescent , Antitubercular Agents/therapeutic use , Biopsy , Buttocks , Child , Disease Progression , Ethambutol/therapeutic use , Female , Humans , Isoniazid/therapeutic use , Lupus Vulgaris/pathology , Pyrazinamide/therapeutic use , Pyridoxine/therapeutic use , Rifampin/therapeutic use , Tuberculin Test , Vitamin B Complex/therapeutic useABSTRACT
BACKGROUND: The epidemiological aspects and diagnostic problems encountered in a rural set up are largely unknown. The present study on cutaneous tuberculosis encompassing clinical, pathological and epidemiological aspects was undertaken at Rajah Muthiah Medical college and Hospital (RMMC&H), a teaching hospital mainly catering to the health needs of a predominantly rural population from villages and hamlets around Chidambaram, a taluq headquarters, located in Cuddalore district ofTamil Nadu. MATERIAL AND METHODS: During the period of study, 5744 cases (82%) of pulmonary tuberculosis and 1261 (18%) of extra-pulmonary tuberculosis were encountered. Cutaneous tuberculosis accounted for 117 (1.67%) of tuberculosis cases. RESULTS: Of the seventy-one patients with cutaneous tuberculosis, 39 had lupus vulgaris and 32 with TBVC. Lupus vulgaris was more prevalent with male pre-ponderance. The maximum incidence was seen in the second decade of life. Both LV and TBVC showed a male pre-ponderance, M:F ratio being 3:2 and 2:1 in LV and TBVC respectively. A majority of patients with LV (27 cases; 69.2%) and TBVC (31 cases; 96.8%) manifested with a single site of involvement. Lower extremities were more commonly involved among patients hailing from poor economic strata who were not habituated to the use of footwear while working out doors. Over crowding was also a contributing factor. The relationships between BCG vaccination and Mantoux test with cutaneous tuberculosis, association with pulmonary tuberculosis in addition to the underlying predisposing socio-economic factors are discussed.
Subject(s)
Tuberculosis, Cutaneous/epidemiology , Adolescent , Adult , Aged , Child , Child, Preschool , Female , Humans , India , Male , Middle Aged , Rural Health/statistics & numerical data , Sex Factors , Tuberculosis, Cutaneous/diagnosis , Young AdultSubject(s)
Tuberculosis, Cutaneous/epidemiology , Tuberculosis, Cutaneous/pathology , Adolescent , Adult , Aged , Aged, 80 and over , Child , Child, Preschool , Female , Humans , Male , Middle Aged , Tuberculosis, Cutaneous/diagnosis , Young AdultABSTRACT
Tuberculosis Verrucosa Cutis (TBVC) or warty tuberculosis is a variant of cutaneous tuberculosis in patients with good cell mediated immunity (CMI) to Mycobacterium Tuberculosis, while Miliary Tuberculosis is associated with very poor CMI. Two widely different clinical presentations in the same patient are very rare and being reported.
Subject(s)
Foot Dermatoses/pathology , Tuberculosis, Cutaneous/pathology , Tuberculosis, Miliary/pathology , Adult , Foot/microbiology , Foot/pathology , Foot Dermatoses/microbiology , Humans , Male , Mycobacterium tuberculosis/isolation & purification , Penis/microbiology , Penis/pathology , Skin/microbiology , Skin/pathology , Treatment Outcome , Tuberculosis, Cutaneous/microbiology , Tuberculosis, Miliary/microbiologyABSTRACT
Tuberculosis affects the population world wide, more among those living in developing countries. The incidence of tuberculosis registered an upward trend even in developed countries, with the advent of HIV infection. Cutaneous tuberculosis accounts for about 1% of cases of extra-pulmonary tuberculosis. Cutaneous tuberculosis presents with various lesions ranging from ulcerative to proliferative or hyperkeratotic lesions. The lesions may sometimes be associated with marked destruction of the tissues resulting in marked disfigurement, especially when it involves face as seen in cases of Lupus Vulgaris. A case of Lupus Vulgaris in a young woman with extensive ulceration of face which responded to ATT resulting in scarring of the face is reported for its rarity amongst Indian population as against western population.
Subject(s)
Lupus Vulgaris/pathology , Skin/pathology , Adult , Biopsy , Diagnosis, Differential , Female , Humans , India , Lupus Vulgaris/microbiology , Mycobacterium tuberculosis/isolation & purification , Skin/microbiologyABSTRACT
Cutaneous larva migrans or creeping eruption is an uncommon parasitic skin infection caused by the filariform larvae of dog or cat hook worms. We report a case of larva migrans on the anterior abdominal wall, in a 52 year old lady, who did gardening as a hobby.
Subject(s)
Larva Migrans/diagnosis , Abdomen/parasitology , Albendazole/therapeutic use , Anthelmintics/therapeutic use , Cryotherapy , Female , Humans , Larva Migrans/therapy , Middle AgedSubject(s)
Foot Ulcer/microbiology , Lupus Vulgaris/pathology , Adolescent , Chronic Disease , Female , HumansABSTRACT
Disabling pansclerotic morphea is a rare atrophying and sclerosing disorder of the subcutaneous tissue, muscle and bone. It is characterized by atrophy of the skin, subcutaneous fat, muscle and bone involving half of the face. In some patients the atrophic lesions extend to involve the ipsilateral or contralateral upper and lower limbs with radiological evidence of hemiatrophy. The patients may present with arthralgia, convulsions or cramps. We report a case of a woman with deformity of face, and left upper and lower limbs that had started as an indurated plaque on the left half of forehead at the age of 5 years and had gradually enlarged, followed by the development of atrophic changes in left eye. The case is being reported in view of its rare occurrence.
Subject(s)
Elbow Joint/physiopathology , Facial Hemiatrophy/diagnosis , Scleroderma, Localized/diagnosis , Adult , Contracture/diagnosis , Female , Humans , Prognosis , Risk Assessment , Scleroderma, Localized/therapy , Severity of Illness IndexABSTRACT
BACKGROUND: Differentiation of cutaneous tuberculosis from other infective granulomas of the skin is difficult due to paucity of the organisms in tissue biopsies. Polymerase chain reaction (PCR) is a newer technique to identify the DNA of Mycobacterium tuberculosis in the tissues. AIM: We examined the utility of PCR as a tool for rapid diagnosis of cutaneous tuberculosis especially in cases negative by ZN staining and culture. MATERIAL AND METHODS: Twenty five random skin biopsies from patients with various types of cutaneous tuberculosis were subjected to PCR. RESULTS: An overall positivity of 64% was observed, which is comparable to other series. Seventy five percent of lupus vulgaris cases, 62.2% of tuberculosis verrucosa cutis and 50% of scrofuloderma cases showed PCR positivity. CONCLUSION: Though useful, the cost and the technique involved limit the use of PCR in developing countries like ours.