ABSTRACT
This study was carried out to assess the efficacy and tolerability of the topical application of an aqueous extract of Triticum vulgare (TV) in different vehicles (cream, impregnated gauzes, foam, hydrogel, and dressing gel) for the treatment of venous lower leg ulcers. Fifty patients were randomized to receive one of the five investigational vehicles. Treatment was performed up to complete healing or to a maximum of 29 days. The wound size reduction from baseline was the primary efficacy variable, which was measured by means of a noninvasive laser scanner instrument for wound assessment. In all groups, apart from the foam group, a similar trend toward the reduction of the surface area was observed. The cream showed the greatest effect on the mean reduction of the lesion size. At last visit, six ulcers were healed: two in the cream group, three in the gauze group, and one in the dressing gel group. In the patients treated with the cream, the gauzes, the hydrogel, and the dressing gel, the reduction of lesion size was 40%-50%; the reduction was smaller in the foam group. No impact in terms of age on the healing process was found. The Total Symptoms Score decreased in all groups during the study; a greater efficacy in terms of signs/symptoms was observed in the patients treated with the gauzes. In the dressing gel group, one patient had an infection of the wound after 3 weeks of treatment and 2 of colonization, leading to a systemic antibiotic treatment. The events were judged as nonrelated to the device used. On the basis of the results, it could be argued that the medical device may be useful in the treatment of chronic venous ulcers.
Subject(s)
Plant Extracts/administration & dosage , Triticum/chemistry , Varicose Ulcer/drug therapy , Wound Healing/drug effects , Aged , Aged, 80 and over , Bandages , Chemistry, Pharmaceutical , Dosage Forms , Female , Humans , Hydrogels , Male , Middle Aged , Pilot Projects , Plant Extracts/therapeutic use , Varicose Ulcer/pathologyABSTRACT
We analyze the role of collagenase, as an indispensable resource for the management and control of the devitalized tissue in the framework of the the wound bed preparation. An analysis and discussion of the physiopathological aspects of collagenase has been performed through a bibliographic review.
Subject(s)
Collagenases/therapeutic use , Skin Ulcer/pathology , Skin Ulcer/therapy , Humans , Necrosis/therapy , Wound HealingABSTRACT
Se analiza la función de la colagenasa como un recurso imprescindible para el abordaje y control del tejido desvitalizado en el contexto de la preparación del lecho de la herida. Se realiza un análisis y discusión de los aspectos fisiopatológicos de la colagenasa mediante una revisión bibliográfica (AU)
We analize the role of collagenase, as an indispensable resource for the management and control of the devitalized tissue in the framework of the the wound bed preparation. An analysis and discussion of the physiopathological aspects of collagenase has been performed through a bibliographic review (AU)
